Slowly-Conducting Pyramidal Tract Neurons in Macaque and Rat.
corticospinal
macaque
monkey
pyramidal tract
rat
Journal
Cerebral cortex (New York, N.Y. : 1991)
ISSN: 1460-2199
Titre abrégé: Cereb Cortex
Pays: United States
ID NLM: 9110718
Informations de publication
Date de publication:
14 05 2020
14 05 2020
Historique:
received:
14
06
2019
revised:
22
08
2019
accepted:
02
09
2019
pubmed:
7
2
2020
medline:
17
11
2021
entrez:
7
2
2020
Statut:
ppublish
Résumé
Anatomical studies report a large proportion of fine myelinated fibers in the primate pyramidal tract (PT), while very few PT neurons (PTNs) with slow conduction velocities (CV) (<~10 m/s) are reported electrophysiologically. This discrepancy might reflect recording bias toward fast PTNs or prevention of antidromic invasion by recurrent inhibition (RI) of slow PTNs from faster axons. We investigated these factors in recordings made with a polyprobe (32 closely-spaced contacts) from motor cortex of anesthetized rats (n = 2) and macaques (n = 3), concentrating our search on PTNs with long antidromic latencies (ADLs). We identified 21 rat PTNs with ADLs >2.6 ms and estimated CV 3-8 m/s, and 67 macaque PTNs (>3.9 ms, CV 6-12 m/s). Spikes of most slow PTNs were small and present on only some recording contacts, while spikes from simultaneously recorded fast-conducting PTNs were large and appeared on all contacts. Antidromic thresholds were similar for fast and slow PTNS, while spike duration was considerably longer in slow PTNs. Most slow PTNs showed no signs of failure to respond antidromically. A number of tests, including intracortical microinjection of bicuculline (GABAA antagonist), failed to provide any evidence that RI prevented antidromic invasion of slow PTNs. Our results suggest that recording bias is the main reason why previous studies were dominated by fast PTNs.
Identifiants
pubmed: 32026928
pii: 5686227
doi: 10.1093/cercor/bhz318
pmc: PMC7197198
doi:
Substances chimiques
GABA-A Receptor Antagonists
0
Bicuculline
Y37615DVKC
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
3403-3418Subventions
Organisme : Wellcome Trust
ID : 102849/Z/13/Z
Pays : United Kingdom
Organisme : Medical Research Council
ID : MR/P012922/1
Pays : United Kingdom
Organisme : Biotechnology and Biological Sciences Research Council
ID : BB/P019757/1
Pays : United Kingdom
Informations de copyright
© The Author(s) 2019. Published by Oxford University Press.
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