Polygenic liability for schizophrenia and childhood adversity influences daily-life emotion dysregulation and psychosis proneness.
Adolescent
Adverse Childhood Experiences
/ psychology
Affect
Child
Ecological Momentary Assessment
Emotional Regulation
Female
Gene-Environment Interaction
Humans
Male
Multifactorial Inheritance
/ genetics
Psychotic Disorders
/ genetics
Risk Factors
Schizophrenia
/ genetics
Stress, Psychological
/ genetics
Twins
Young Adult
childhood trauma
daily-life stressors
emotion regulation
experience sampling method
gene-environment interaction
psychosis
Journal
Acta psychiatrica Scandinavica
ISSN: 1600-0447
Titre abrégé: Acta Psychiatr Scand
Pays: United States
ID NLM: 0370364
Informations de publication
Date de publication:
05 2020
05 2020
Historique:
received:
22
10
2019
revised:
23
01
2020
accepted:
02
02
2020
pubmed:
7
2
2020
medline:
11
5
2021
entrez:
7
2
2020
Statut:
ppublish
Résumé
To test whether polygenic risk score for schizophrenia (PRS-S) interacts with childhood adversity and daily-life stressors to influence momentary mental state domains (negative affect, positive affect, and subtle psychosis expression) and stress-sensitivity measures. The data were retrieved from a general population twin cohort including 593 adolescents and young adults. Childhood adversity was assessed using the Childhood Trauma Questionnaire. Daily-life stressors and momentary mental state domains were measured using ecological momentary assessment. PRS-S was trained on the latest Psychiatric Genetics Consortium schizophrenia meta-analysis. The analyses were conducted using multilevel mixed-effects tobit regression models. Both childhood adversity and daily-life stressors were associated with increased negative affect, decreased positive affect, and increased subtle psychosis expression, while PRS-S was only associated with increased positive affect. No gene-environment correlation was detected. There is novel evidence for interaction effects between PRS-S and childhood adversity to influence momentary mental states [negative affect (b = 0.07, P = 0.013), positive affect (b = -0.05, P = 0.043), and subtle psychosis expression (b = 0.11, P = 0.007)] and stress-sensitivity measures. Exposure to childhood adversities, particularly in individuals with high PRS-S, is pleiotropically associated with emotion dysregulation and psychosis proneness.
Identifiants
pubmed: 32027017
doi: 10.1111/acps.13158
pmc: PMC7318228
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Twin Study
Langues
eng
Sous-ensembles de citation
IM
Pagination
465-475Informations de copyright
© 2020 The Authors. Acta Psychiatrica Scandinavica published by John Wiley & Sons Ltd.
Références
Soc Psychiatry Psychiatr Epidemiol. 2014 Feb;49(2):169-82
pubmed: 24435092
Lancet Psychiatry. 2017 Jan;4(1):57-62
pubmed: 27932233
Psychol Med. 2019 Aug 15;:1-14
pubmed: 31414981
Mol Psychiatry. 2016 Dec;21(12):1657-1662
pubmed: 27431291
Neuropsychopharmacology. 2008 Dec;33(13):3030-6
pubmed: 17687265
Acta Psychiatr Scand. 2009 Feb;119(2):156-60
pubmed: 18808401
Br J Psychiatry. 2010 Jun;196(6):447-53
pubmed: 20513854
Acta Psychiatr Scand. 2009 Jan;119(1):45-53
pubmed: 18822092
J Child Psychol Psychiatry. 2014 Oct;55(10):1068-87
pubmed: 25132410
Schizophr Bull. 2018 Jun 6;44(4):710-719
pubmed: 29701807
Acta Psychiatr Scand. 2017 Oct;136(4):389-399
pubmed: 28865405
Genes Brain Behav. 2009 Feb;8(1):5-12
pubmed: 18721261
Transl Psychiatry. 2017 Mar 7;7(3):e1053
pubmed: 28267146
PLoS One. 2017 Oct 12;12(10):e0186294
pubmed: 29023568
Science. 2018 Jun 22;360(6395):
pubmed: 29930110
Arch Gen Psychiatry. 2001 Dec;58(12):1137-44
pubmed: 11735842
Clin Psychol Rev. 2007 May;27(4):409-24
pubmed: 17222489
Dev Psychopathol. 2017 Dec;29(5):1921-1933
pubmed: 29162193
Acta Psychiatr Scand. 2011 Jan;123(1):28-35
pubmed: 20712824
Psychoneuroendocrinology. 2018 Oct;96:61-68
pubmed: 29906787
Schizophr Bull. 2017 Jul 1;43(4):693-697
pubmed: 28969353
Am J Med Genet B Neuropsychiatr Genet. 2008 Jan 5;147B(1):10-7
pubmed: 17525974
Psychol Med. 2016 Oct;46(13):2799-813
pubmed: 27400863
Nat Genet. 2016 Oct;48(10):1284-1287
pubmed: 27571263
Psychol Med. 2019 Aug;49(11):1879-1889
pubmed: 30284529
World Psychiatry. 2019 Jun;18(2):173-182
pubmed: 31059627
Nature. 2010 Nov 11;468(7321):203-12
pubmed: 21068828
Schizophr Res. 2019 Mar;205:58-62
pubmed: 29793818
Acta Psychiatr Scand. 2017 Oct;136(4):373-388
pubmed: 28758672
Psychol Med. 2005 May;35(5):733-41
pubmed: 15918350
Psychol Med. 2015 Aug;45(11):2389-401
pubmed: 25804288
JAMA Psychiatry. 2016 Mar;73(3):221-8
pubmed: 26818099
Schizophr Bull. 2018 Feb 15;44(2):338-347
pubmed: 29036523
Psychol Med. 2015 Apr;45(6):1277-88
pubmed: 25273550
Acta Psychiatr Scand. 2016 Feb;133(2):91-101
pubmed: 25961128
JAMA Psychiatry. 2017 May 1;74(5):528-534
pubmed: 28355471
Psychol Med. 2018 Jan;48(2):229-244
pubmed: 28689498
Nat Neurosci. 2015 Jul;18(7):953-5
pubmed: 26053403
Psychol Med. 2012 May;42(5):1003-12
pubmed: 22067414
Neurosci Biobehav Rev. 2017 Apr;75:393-406
pubmed: 28216171
Psychol Med. 2017 Dec;47(16):2743-2752
pubmed: 28578740
Schizophr Res. 2018 Jul;197:2-8
pubmed: 29129507
Acta Psychiatr Scand. 2011 Jan;123(1):12-20
pubmed: 20712828
Child Abuse Negl. 2003 Feb;27(2):169-90
pubmed: 12615092
J Psychosom Res. 2006 Aug;61(2):229-36
pubmed: 16880026
Acta Psychiatr Scand. 2020 May;141(5):465-475
pubmed: 32027017
Pers Soc Psychol Rev. 2012 Aug;16(3):262-82
pubmed: 22291044
Nat Genet. 2018 Mar;50(3):381-389
pubmed: 29483656
Int J Epidemiol. 2005 Oct;34(5):1089-99
pubmed: 16087687
Eur Psychiatry. 2017 Sep;45:167-173
pubmed: 28957783
Genes Brain Behav. 2014 Jan;13(1):25-37
pubmed: 24219237
World Psychiatry. 2017 Oct;16(3):225-226
pubmed: 28941096
PLoS One. 2013;8(2):e54653
pubmed: 23457452
Biol Psychiatry. 2014 Jan 1;75(1):18-24
pubmed: 24135711
BMC Psychiatry. 2016 Jul 08;16:223
pubmed: 27391407
Am J Med Genet B Neuropsychiatr Genet. 2015 Jul;168B(5):392-401
pubmed: 25963331
Am J Hum Genet. 2007 Sep;81(3):559-75
pubmed: 17701901
Am J Hum Genet. 2008 Jul;83(1):132-5; author reply 135-9
pubmed: 18606306
Acta Psychiatr Scand. 2003 Feb;107(2):124-31
pubmed: 12534438
Schizophr Bull. 2016 May;42(3):712-22
pubmed: 26834027
Schizophr Bull. 2016 Jul;42(4):870-3
pubmed: 27179124
Psychol Med. 2011 Nov;41(11):2305-15
pubmed: 21733219
Am J Psychiatry. 2014 Apr;171(4):395-7
pubmed: 24687194
Schizophr Bull. 2017 Oct 21;43(6):1197-1207
pubmed: 28338919
Nat Genet. 2006 Aug;38(8):904-9
pubmed: 16862161
Schizophr Res. 2017 May;183:49-55
pubmed: 27881233
Twin Res Hum Genet. 2013 Feb;16(1):58-63
pubmed: 23101489
PLoS One. 2017 Aug 23;12(8):e0183695
pubmed: 28832672
Evid Based Ment Health. 2016 Aug;19(3):86-9
pubmed: 27443678
Br Med J (Clin Res Ed). 1987 Sep 19;295(6600):681-2
pubmed: 3117295
Psychol Med. 2017 Oct;47(14):2421-2437
pubmed: 28436345
Psychol Med. 2009 Sep;39(9):1533-47
pubmed: 19215626
Neurosci Biobehav Rev. 2017 Feb;73:191-218
pubmed: 27993603
Psychol Med. 2009 Jul;39(7):1077-86
pubmed: 18834553
Annu Rev Clin Psychol. 2008;4:1-32
pubmed: 18509902
Schizophr Bull. 2019 Sep 11;45(5):960-965
pubmed: 31508804
Schizophr Bull. 2018 Oct 17;44(6):1175-1179
pubmed: 30169883