Cardiovascular phenotype of mice lacking 3-mercaptopyruvate sulfurtransferase.

Animals Antioxidants / metabolism Cardiovascular System / enzymology Cystathionine beta-Synthase / genetics Cystathionine gamma-Lyase / genetics Gene Expression Regulation, Enzymologic Hydrogen Sulfide / blood Male Mice, Inbred C57BL Mice, Knockout Myocardial Reperfusion Injury / genetics Myocytes, Cardiac / enzymology Nitric Oxide / metabolism Phenotype Reactive Oxygen Species / metabolism Sulfurtransferases / genetics Vasodilation / drug effects
3-mercaptopyruvate transferase (3-MST) Aging Blood pressure Myocardial infarction Nitric Oxide (NO) Reactive Oxygen Species (ROS)

Journal

Biochemical pharmacology
ISSN: 1873-2968
Titre abrégé: Biochem Pharmacol
Pays: England
ID NLM: 0101032

Informations de publication

Date de publication:
06 2020
Historique:
received: 18 11 2019
accepted: 30 01 2020
pubmed: 7 2 2020
medline: 27 10 2020
entrez: 7 2 2020
Statut: ppublish

Résumé

Hydrogen sulfide (H 3-MST is the most abundant transcript in the mouse heart, compared to CSE and CBS. 3-MST was mainly localized in smooth muscle cells and cardiomyocytes, where it was present in both the mitochondria and the cytosol. Levels of serum and cardiac H Overall, genetic ablation of 3-MST impacts on the mouse cardiovascular system in an age-dependent manner. Loss of 3-MST exerts a cardioprotective role in young adult mice, while with aging it predisposes them to hypertension and cardiac hypertrophy.

Identifiants

DOI: 10.1016/j.bcp.2020.113833 PMID: 32027885 PMC: PMC7657663
pubmed: 32027885
pii: S0006-2952(20)30043-5
doi: 10.1016/j.bcp.2020.113833
pmc: PMC7657663
mid: NIHMS1644365
pii:
doi:

Substances chimiques

Antioxidants 0
Reactive Oxygen Species 0
Nitric Oxide 31C4KY9ESH
Sulfurtransferases EC 2.8.1.-
3-mercaptopyruvate sulphurtransferase EC 2.8.1.2
Cystathionine beta-Synthase EC 4.2.1.22
Cystathionine gamma-Lyase EC 4.4.1.1
Hydrogen Sulfide YY9FVM7NSN

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

113833

Subventions

Organisme : NHLBI NIH HHS
ID : R01 HL092141
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL146098
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL146514
Pays : United States
Organisme : NHLBI NIH HHS
ID : R56 HL137711
Pays : United States

Informations de copyright

Copyright © 2020 Elsevier Inc. All rights reserved.

Déclaration de conflit d'intérêts

Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.

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Auteurs

Maria Peleli (M)

Clinical, Experimental Surgery and Translational Research Center, Biomedical Research Foundation of the Academy of Athens, Greece; Laboratory of Pharmacology, Faculty of Pharmacy, National and Kapodistrian University of Athens, Greece.

Sofia-Iris Bibli (SI)

Institute for Vascular Signalling, Centre for Molecular Medicine, Goethe University, Frankfurt am Main, German Centre for Cardiovascular Research (DZHK) Partner Site Rhein-Main, Frankfurt am Main, Germany.

Zhen Li (Z)

Cardiovascular Center of Excellence, Louisiana State University Health Sciences Center, New Orleans, LA, USA.

Athanasia Chatzianastasiou (A)

"George P. Livanos and Marianthi Simou" Laboratories, First Department of Pulmonary and Critical Care Medicine, Evangelismos Hospital, Faculty of Medicine, National and Kapodistrian University of Athens, Athens, Greece.

Aimilia Varela (A)

Clinical, Experimental Surgery and Translational Research Center, Biomedical Research Foundation of the Academy of Athens, Greece.

Antonia Katsouda (A)

Clinical, Experimental Surgery and Translational Research Center, Biomedical Research Foundation of the Academy of Athens, Greece.

Sven Zukunft (S)

Institute for Vascular Signalling, Centre for Molecular Medicine, Goethe University, Frankfurt am Main, German Centre for Cardiovascular Research (DZHK) Partner Site Rhein-Main, Frankfurt am Main, Germany.

Mariarosaria Bucci (M)

Department of Pharmacy, School of Medicine, University of Naples Federico II, Naples, Italy.

Valentina Vellecco (V)

Department of Pharmacy, School of Medicine, University of Naples Federico II, Naples, Italy.

Constantinos H Davos (CH)

Clinical, Experimental Surgery and Translational Research Center, Biomedical Research Foundation of the Academy of Athens, Greece.

Noriyuki Nagahara (N)

Isotope Research Center, Nippon Medical School, Tokyo, Japan.

Giuseppe Cirino (G)

Department of Pharmacy, School of Medicine, University of Naples Federico II, Naples, Italy.

Ingrid Fleming (I)

Institute for Vascular Signalling, Centre for Molecular Medicine, Goethe University, Frankfurt am Main, German Centre for Cardiovascular Research (DZHK) Partner Site Rhein-Main, Frankfurt am Main, Germany.

David J Lefer (DJ)

Cardiovascular Center of Excellence, Louisiana State University Health Sciences Center, New Orleans, LA, USA.

Andreas Papapetropoulos (A)

Clinical, Experimental Surgery and Translational Research Center, Biomedical Research Foundation of the Academy of Athens, Greece; Laboratory of Pharmacology, Faculty of Pharmacy, National and Kapodistrian University of Athens, Greece. Electronic address: apapapet@pharm.uoa.gr.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Cardiovascular phenotype of mice lacking...
questionsmedicales.fr › Actions chimiques et utilisations › Utilisations spécialisées de produits chimiques › Agents protecteurs › Antioxydants › Cardiovascular phenotype of mice lacking...
questionsmedicales.fr › Système cardiovasculaire › Cardiovascular phenotype of mice lacking...
questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Lyases › Carbon-oxygen lyases › Hydro-lyases › Cystathionine beta-synthase › Cardiovascular phenotype of mice lacking...
questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Lyases › Carbon-sulfur lyases › Cystathionine gamma-lyase › Cardiovascular phenotype of mice lacking...
questionsmedicales.fr › Phénomènes génétiques › Régulation de l'expression des gènes › Régulation de l'expression des gènes codant pour des enzymes › Cardiovascular phenotype of mice lacking...
questionsmedicales.fr › Produits chimiques inorganiques › Sulfure d'hydrogène › Cardiovascular phenotype of mice lacking...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Lignées consanguines de souris › Souris de lignée C57BL › Cardiovascular phenotype of mice lacking...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Souris transgéniques › Souris knockout › Cardiovascular phenotype of mice lacking...
questionsmedicales.fr › États, signes et symptômes pathologiques › Processus pathologiques › Complications postopératoires › Lésion d'ischémie-reperfusion › Lésion de reperfusion myocardique › Cardiovascular phenotype of mice lacking...
questionsmedicales.fr › Cellules › Cellules musculaires › Myocytes cardiaques › Cardiovascular phenotype of mice lacking...
questionsmedicales.fr › Produits chimiques inorganiques › Composés de l'oxygène › Oxydes › Oxydes d'azote › Monoxyde d'azote › Cardiovascular phenotype of mice lacking...
questionsmedicales.fr › Phénomènes génétiques › Phénotype › Cardiovascular phenotype of mice lacking...
questionsmedicales.fr › Produits chimiques inorganiques › Composés de l'oxygène › Espèces réactives de l'oxygène › Cardiovascular phenotype of mice lacking...
questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Transferases › Sulfur group transferases › Sulfurtransferases › Cardiovascular phenotype of mice lacking...
questionsmedicales.fr › Phénomènes physiologiques respiratoires et circulatoires › Phénomènes physiologiques cardiovasculaires › Hémodynamique › Vasodilatation › Cardiovascular phenotype of mice lacking...