Genomic characterization of Parengyodontium americanum sp. nov.
Comparative genomics
Hypocreales
Opportunistic fungal pathogen
Parengyodontium americanum
Journal
Fungal genetics and biology : FG & B
ISSN: 1096-0937
Titre abrégé: Fungal Genet Biol
Pays: United States
ID NLM: 9607601
Informations de publication
Date de publication:
05 2020
05 2020
Historique:
received:
30
03
2019
revised:
29
01
2020
accepted:
31
01
2020
pubmed:
7
2
2020
medline:
20
4
2021
entrez:
7
2
2020
Statut:
ppublish
Résumé
Modern genome analysis and phylogenomic methods have increased the number of fungal species, as well as enhanced appreciation of the degree of diversity within the fungal kingdom. In this context, we describe a new Parengyodontium species, P. americanum, which is phylogenetically related to the opportunistic human fungal pathogen P. album. Five unusual fungal isolates were recovered from five unique and confirmed coccidioidomycosis patients, and these isolates were subsequently submitted to detailed molecular and morphological identification procedures to determine identity. Molecular and morphological diagnostic analyses showed that the isolates belong to the Cordycipitaceae. Subsequently, three representative genomes were sequenced and annotated, and a new species, P. americanum, was identified. Using various genomic analyses, gene family expansions related to novel compounds and potential for ability to grow in diverse habitats are predicted. A general description of the genomic composition of this newly described species and comparison of genome content with Beauveria bassiana, Isaria fumosorosea and Cordyceps militaris shows a shared core genome of 6371 genes, and 148 genes that appear to be specific for P. americanum. This work provides the framework for future investigations of this interesting fungal species.
Identifiants
pubmed: 32028048
pii: S1087-1845(19)30108-2
doi: 10.1016/j.fgb.2020.103351
pmc: PMC7194163
mid: NIHMS1565547
pii:
doi:
Substances chimiques
Fungal Proteins
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
103351Subventions
Organisme : NIAID NIH HHS
ID : R21 AI128536
Pays : United States
Informations de copyright
Copyright © 2020 Elsevier Inc. All rights reserved.
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