Clinical relevance of Scedosporium spp. and Exophiala dermatitidis in patients with cystic fibrosis: A nationwide study.
Adolescent
Adult
Child
Cross-Sectional Studies
Cystic Fibrosis
/ complications
Exophiala
/ isolation & purification
Female
Humans
Invasive Fungal Infections
/ diagnosis
Male
Netherlands
/ epidemiology
Phaeohyphomycosis
/ diagnosis
Prevalence
Scedosporium
/ isolation & purification
Sputum
/ microbiology
Young Adult
Exophiala
Scedosporium
cystic fibrosis
epidemiology
filamentous fungi
Journal
Medical mycology
ISSN: 1460-2709
Titre abrégé: Med Mycol
Pays: England
ID NLM: 9815835
Informations de publication
Date de publication:
01 Oct 2020
01 Oct 2020
Historique:
received:
04
12
2019
revised:
09
01
2020
accepted:
24
01
2020
pubmed:
8
2
2020
medline:
27
5
2021
entrez:
8
2
2020
Statut:
ppublish
Résumé
An increased prevalence of various filamentous fungi in sputum samples of patients with cystic fibrosis (CF) has been reported. The clinical significance, however, is mostly unclear. The aim of this study was to investigate the clinical relevance of Scedosporium spp. and Exophiala dermatitidis from sputum samples of patients with CF in the Netherlands. In this cross-sectional study, all CF patients of the Dutch national CF registry who were treated at five of the seven recognized CF centers during a 3-year period were included. We linked clinical data of the national CF registry with the national Dutch filamentous fungal database. We investigated the association between clinical characteristics and a positive sputum sample for Scedosporium spp. and E. dermatitidis, using logistic regression. Positive cultures for fungi were obtained from 3787 sputum samples from 699 of the 1312 patients with CF. Scedosporium spp. was associated with severe genotype, CF-related diabetes, several microorganisms, and inhaled antibiotics. E. dermatitidis was associated with older age, female sex, and Aspergillus spp. CF patients with and without Scedosporium spp. or E. dermatitidis seemed comparable in body mass index and lung function. This study suggests that Scedosporium spp. and E. dermatitidis are probably no major pathogens in CF patients in the Netherlands. Greater understanding of epidemiologic trends, risk factors, and pathogenicity of filamentous fungi in the respiratory tracts of patients with CF is needed.
Identifiants
pubmed: 32030418
pii: 5728812
doi: 10.1093/mmy/myaa003
pmc: PMC7527267
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
859-866Informations de copyright
© The Author(s) 2020. Published by Oxford University Press on behalf of The International Society for Human and Animal Mycology.
Références
J Clin Microbiol. 2011 Mar;49(3):1004-9
pubmed: 21209163
Mycoses. 2003 Feb;46(1-2):19-23
pubmed: 12588478
Med Mycol. 2016 Jul 1;54(5):537-43
pubmed: 26782645
J Cyst Fibros. 2010 Mar;9(2):110-6
pubmed: 20045384
Lancet Infect Dis. 2016 Nov;16(11):e251-e260
pubmed: 27638360
Pediatr Pulmonol. 2019 Feb;54(2):133-140
pubmed: 30549449
J Cyst Fibros. 2013 May;12(3):187-93
pubmed: 23491855
Mycopathologia. 2018 Feb;183(1):185-200
pubmed: 28929280
Med Mycol. 2010 Nov;48 Suppl 1:S4-9
pubmed: 21067329
Int J Biochem Cell Biol. 2014 Jul;52:161-73
pubmed: 24625547
J Cyst Fibros. 2015 Mar;14(2):237-41
pubmed: 25595044
Med Mycol. 2012 Jul;50(5):497-508
pubmed: 22004363
Med Mycol. 2010 Nov;48 Suppl 1:S37-44
pubmed: 21067328
J Antimicrob Chemother. 2018 Aug 1;73(8):2047-2053
pubmed: 29684150
Med Mycol. 2019 Feb 1;57(2):155-160
pubmed: 29554296
Med Mycol. 2013 Jul;51(5):493-8
pubmed: 23167707
Lancet. 2016 Nov 19;388(10059):2519-2531
pubmed: 27140670
Clin Microbiol Infect. 2009 Jul;15(7):689-93
pubmed: 19549223
Clin Microbiol Rev. 2008 Jan;21(1):157-97
pubmed: 18202441
Med Mycol. 2010 Nov;48 Suppl 1:S32-6
pubmed: 21067327
J Clin Microbiol. 2010 Jan;48(1):314-6
pubmed: 19906904
J Cyst Fibros. 2019 Mar;18(2):221-226
pubmed: 30514613
J Cyst Fibros. 2019 Mar;18(2):227-232
pubmed: 30297214
Lancet. 2009 May 30;373(9678):1891-904
pubmed: 19403164
Chest. 2010 Jan;137(1):171-6
pubmed: 19567494
Front Microbiol. 2015 Aug 24;6:866
pubmed: 26379643
Eur J Clin Microbiol Infect Dis. 2000 Jan;19(1):53-6
pubmed: 10706182
J Cyst Fibros. 2008 Nov;7(6):566-72
pubmed: 18723404
Mycopathologia. 2018 Feb;183(1):33-43
pubmed: 28864921