Universal and Naked-Eye Gene Detection Platform Based on the Clustered Regularly Interspaced Short Palindromic Repeats/Cas12a/13a System.
Journal
Analytical chemistry
ISSN: 1520-6882
Titre abrégé: Anal Chem
Pays: United States
ID NLM: 0370536
Informations de publication
Date de publication:
03 03 2020
03 03 2020
Historique:
pubmed:
8
2
2020
medline:
14
1
2021
entrez:
8
2
2020
Statut:
ppublish
Résumé
Gold-nanoparticles-based colorimetric assay is an attractive detection format, but is limited by the tedious and ineffective posthybridization manipulations for genomic analysis. Here, we present a new design for a colorimetric gene-sensing platform based on the clustered regularly interspaced short palindromic repeats (CRISPR)/Cas system. In this strategy, programmable recognition of DNA by Cas12a/crRNA and RNA by Cas13a/crRNA with a complementary target activates the
Identifiants
pubmed: 32031369
doi: 10.1021/acs.analchem.9b05597
doi:
Substances chimiques
DNA Probes
0
DNA, Viral
0
MicroRNAs
0
RNA, Ribosomal, 16S
0
Gold
7440-57-5
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM