Discovery of Potent Dual-Tailed Benzenesulfonamide Inhibitors of Human Carbonic Anhydrases Implicated in Glaucoma and in Vivo Profiling of Their Intraocular Pressure-Lowering Action.

Animals Carbonic Anhydrase Inhibitors / chemical synthesis Carbonic Anhydrases / chemistry Catalytic Domain Crystallography, X-Ray Drug Design Glaucoma / drug therapy Humans Intraocular Pressure / drug effects Male Molecular Structure Protein Binding Rabbits Structure-Activity Relationship Sulfonamides / chemical synthesis

Journal

Journal of medicinal chemistry
ISSN: 1520-4804
Titre abrégé: J Med Chem
Pays: United States
ID NLM: 9716531

Informations de publication

Date de publication:
26 03 2020
Historique:
pubmed: 8 2 2020
medline: 15 9 2020
entrez: 8 2 2020
Statut: ppublish

Résumé

The design of three dual-tailed sulfonamide series

Identifiants

DOI: 10.1021/acs.jmedchem.9b02090 PMID: 32031797
pubmed: 32031797
doi: 10.1021/acs.jmedchem.9b02090
doi:

Substances chimiques

Carbonic Anhydrase Inhibitors 0
Sulfonamides 0
Carbonic Anhydrases EC 4.2.1.1

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

3317-3326

Auteurs

Mohamed Fares (M)

School of Chemistry & Molecular Bioscience, Molecular Horizons, and Illawarra Health & Medical Research Institute, University of Wollongong, Wollongong, NSW 2522, Australia.
School of Chemistry, The University of Sydney, Sydney, NSW 2006, Australia.
ORCID: 0000-0003-0589-3955

Wagdy M Eldehna (WM)

Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Kafrelsheikh University, Kafr El-Sheikh 33516, Egypt.

Silvia Bua (S)

Department of NEUROFARBA, Section of Pharmaceutical and Nutraceutical Sciences, University of Florence, Via Ugo Schiff 6, Sesto Fiorentino, 50019 Florence, Italy.

Cecilia Lanzi (C)

Department of NEUROFARBA, Section of Pharmacology and Toxicology, University of Florence, Viale Gaetano Pieraccini 6, 50100 Florence, Italy.

Laura Lucarini (L)

Department of NEUROFARBA, Section of Pharmacology and Toxicology, University of Florence, Viale Gaetano Pieraccini 6, 50100 Florence, Italy.

Emanuela Masini (E)

Department of NEUROFARBA, Section of Pharmacology and Toxicology, University of Florence, Viale Gaetano Pieraccini 6, 50100 Florence, Italy.

Thomas S Peat (TS)

Biomedical Manufacturing Program, CSIRO, 343 Royal Parade, Parkville, VIC 3052, Australia.

Hatem A Abdel-Aziz (HA)

Department of Applied Organic Chemistry, National Research Center, Dokki, Giza 12622, Egypt.

Alessio Nocentini (A)

Department of NEUROFARBA, Section of Pharmaceutical and Nutraceutical Sciences, University of Florence, Via Ugo Schiff 6, Sesto Fiorentino, 50019 Florence, Italy.
ORCID: 0000-0003-3342-702X

Paul A Keller (PA)

School of Chemistry & Molecular Bioscience, Molecular Horizons, and Illawarra Health & Medical Research Institute, University of Wollongong, Wollongong, NSW 2522, Australia.
ORCID: 0000-0003-4868-845X

Claudiu T Supuran (CT)

Department of NEUROFARBA, Section of Pharmaceutical and Nutraceutical Sciences, University of Florence, Via Ugo Schiff 6, Sesto Fiorentino, 50019 Florence, Italy.
ORCID: 0000-0003-4262-0323

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Discovery of Potent Dual-Tailed...
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Mécanismes moléculaires de l'action pharmacologique › Antienzymes › Inhibiteurs de l'anhydrase carbonique › Discovery of Potent Dual-Tailed...
questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Lyases › Carbon-oxygen lyases › Hydro-lyases › Carbonic anhydrases › Discovery of Potent Dual-Tailed...
questionsmedicales.fr › Phénomènes chimiques › Phénomènes biochimiques › Conformation moléculaire › Conformation des protéines › Éléments structuraux des protéines › Domaine catalytique › Discovery of Potent Dual-Tailed...
questionsmedicales.fr › Techniques d'investigation › Techniques de chimie analytique › Cristallographie aux rayons X › Discovery of Potent Dual-Tailed...
questionsmedicales.fr › Techniques d'investigation › Développement de médicament › Découverte de médicament › Conception de médicament › Discovery of Potent Dual-Tailed...
questionsmedicales.fr › Maladies de l'oeil › Hypertension oculaire › Glaucome › Discovery of Potent Dual-Tailed...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Discovery of Potent Dual-Tailed...
questionsmedicales.fr › Phénomènes physiologiques oculaires › Pression intraoculaire › Discovery of Potent Dual-Tailed...
questionsmedicales.fr › Phénomènes chimiques › Structure moléculaire › Discovery of Potent Dual-Tailed...
questionsmedicales.fr › Métabolisme › Liaison aux protéines › Discovery of Potent Dual-Tailed...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Lagomorpha › Lapins › Discovery of Potent Dual-Tailed...
questionsmedicales.fr › Phénomènes physiologiques › Phénomènes pharmacologiques et toxicologiques › Phénomènes pharmacologiques › Relation structure-activité › Discovery of Potent Dual-Tailed...
questionsmedicales.fr › Composés chimiques organiques › Composés du soufre › Sulfones › Sulfonamides › Discovery of Potent Dual-Tailed...