Hypoxic-inflammatory responses under acute hypoxia: In Vitro experiments and prospective observational expedition trial.
Adult
Altitude Sickness
/ metabolism
Cell Hypoxia
/ physiology
Cytokines
/ metabolism
Female
Gene Expression
/ physiology
Humans
Hypoxia-Inducible Factor 1, alpha Subunit
/ metabolism
Inflammation
/ metabolism
Leukocytes, Mononuclear
/ metabolism
Male
Prospective Studies
RNA, Messenger
/ metabolism
Signal Transduction
/ physiology
hypoxic-inflammatory response, hypobaric hypoxia, cytokines
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
04 Feb 2020
04 Feb 2020
Historique:
received:
12
12
2019
revised:
29
01
2020
accepted:
01
02
2020
entrez:
9
2
2020
pubmed:
9
2
2020
medline:
18
11
2020
Statut:
epublish
Résumé
Induction of hypoxia-inducible-factor-1α (HIF-1α) pathway and HIF-target genes allow adaptation to hypoxia and are associated with reduced incidence of acute mountain sickness (AMS). Little is known about HIF-pathways in conjunction with inflammation or exercise stimuli under acute hypobaric hypoxia in non-acclimatized individuals. We therefore tested the hypotheses that 1) both hypoxic and inflammatory stimuli induce hypoxic-inflammatory signaling pathways in vitro, 2) similar results are seen in vivo under hypobaric hypoxia, and 3) induction of HIF-dependent genes is associated with AMS in 11 volunteers. In vitro, peripheral blood mononuclear cells (PBMCs) were incubated under hypoxic (10%/5% O
Identifiants
pubmed: 32033172
pii: ijms21031034
doi: 10.3390/ijms21031034
pmc: PMC7037641
pii:
doi:
Substances chimiques
Cytokines
0
Hypoxia-Inducible Factor 1, alpha Subunit
0
RNA, Messenger
0
Types de publication
Journal Article
Observational Study
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : BEXMED (Deutsche Gesellschaft für Berg- und Expeditionsmedizin)
ID : n.a.
Organisme : WIFOMED (Verein für Förderung von Wissenschaft und Forschung an der medizinischen Fakultät der Ludwig- Maximilians-Universität München)
ID : n.a.
Déclaration de conflit d'intérêts
The authors have no conflicts of interest to declare.
Références
Blood. 2015 Oct 22;126(17):2016-26
pubmed: 26286848
Mol Med Rep. 2016 Aug;14(2):1475-82
pubmed: 27356492
J Appl Physiol (1985). 2015 Dec 1;119(11):1297-302
pubmed: 26429867
Front Immunol. 2017 May 30;8:628
pubmed: 28611780
Biochem J. 2006 Jun 15;396(3):517-27
pubmed: 16533170
Nat Med. 2009 May;15(5):497-8
pubmed: 19424210
Aviat Space Environ Med. 2012 Jul;83(7):677-84
pubmed: 22779311
Immunol Res. 2012 Apr;52(1-2):53-63
pubmed: 22392052
Biomed Res Int. 2015;2015:593938
pubmed: 26451374
Endocr Metab Immune Disord Drug Targets. 2009 Dec;9(4):315-27
pubmed: 20028334
Int J Mol Sci. 2017 Jun 14;18(6):
pubmed: 28613249
Adv Exp Med Biol. 2019;1136:113-121
pubmed: 31201720
J Neuroinflammation. 2007 May 02;4:12
pubmed: 17474992
Thromb Haemost. 2009 Aug;102(2):191-7
pubmed: 19652868
Mediators Inflamm. 2016;2016:4851935
pubmed: 27239103
Eur Rev Med Pharmacol Sci. 2017 Apr;21(8):1820-1827
pubmed: 28485797
J Immunol. 2010 Aug 1;185(3):1786-93
pubmed: 20574001
J Neuroinflammation. 2016 Aug 31;13(1):221
pubmed: 27578213
Int J Biochem Mol Biol. 2012;3(2):165-78
pubmed: 22773957
Prog Neurobiol. 2008 Feb;84(2):116-31
pubmed: 18177992
PLoS One. 2018 May 18;13(5):e0197486
pubmed: 29775479
Cancer Cell. 2017 Nov 13;32(5):669-683.e5
pubmed: 29136509
Hypoxia (Auckl). 2017 Jul 14;5:67-74
pubmed: 28770234
Cell Biochem Funct. 2013 Aug;31(6):451-9
pubmed: 23760768
Front Physiol. 2018 Feb 20;9:113
pubmed: 29515456
Ann Occup Environ Med. 2018 Nov 19;30:66
pubmed: 30479778
Exp Physiol. 2016 Jan;101(1):28-32
pubmed: 26391197
Anesthesiology. 2013 Jun;118(6):1426-36
pubmed: 23449494
J Neurosci. 2017 Aug 16;37(33):7878-7892
pubmed: 28716963
Nat Rev Nephrol. 2015 Jun;11(6):326-8
pubmed: 25917556
Am J Respir Crit Care Med. 2000 Oct;162(4 Pt 1):1257-61
pubmed: 11029327
Nat Immunol. 2017 Jul 19;18(8):832-842
pubmed: 28722725
Exerc Immunol Rev. 2005;11:6-16
pubmed: 16385840
Int J Mol Sci. 2014 Nov 26;15(12):21777-87
pubmed: 25431923
Cell Physiol Biochem. 2017;41(4):1271-1284
pubmed: 28278498
Nat Med. 2009 May;15(5):496-7
pubmed: 19424209
Brain Behav Immun. 2017 Aug;64:266-275
pubmed: 28433745
Front Immunol. 2017 Aug 03;8:899
pubmed: 28824627
High Alt Med Biol. 2018 Sep;19(3):249-258
pubmed: 29924642
Immunity. 2003 Oct;19(4):583-93
pubmed: 14563322
Oncotarget. 2016 Feb 16;7(7):7816-28
pubmed: 26761211
Blood Cells Mol Dis. 2012 Aug 15;49(2):67-73
pubmed: 22595196
Methods Enzymol. 2007;435:405-19
pubmed: 17998066
PLoS One. 2014 Aug 18;9(8):e104953
pubmed: 25133403
Aviat Space Environ Med. 1997 Jun;68(6):499-503
pubmed: 9184737
Anesthesiology. 2016 Apr;124(4):923-33
pubmed: 26808636
N Engl J Med. 2011 Feb 17;364(7):656-65
pubmed: 21323543
Am J Physiol. 1946 Aug;146:637-53
pubmed: 20996488
High Alt Med Biol. 2013 Jun;14(2):101-10
pubmed: 23795729
BMC Anesthesiol. 2016 Aug 11;16(1):61
pubmed: 27515179
J Leukoc Biol. 2017 Jan;101(1):107-119
pubmed: 27780875
J Immunol. 2009 May 15;182(10):6470-6
pubmed: 19414801
High Alt Med Biol. 2018 Mar;19(1):4-6
pubmed: 29583031
Anesthesiology. 2016 Apr;124(4):908-22
pubmed: 26978146
J Neuroimmunol. 1996 Jan;64(1):37-43
pubmed: 8598388
FASEB J. 2017 Apr;31(4):1516-1530
pubmed: 28031321
Cardiovasc Res. 2016 Jan 1;109(1):115-30
pubmed: 26503986
High Alt Med Biol. 2018 Jun;19(2):170-177
pubmed: 29608374
J Biol Chem. 2014 May 23;289(21):14656-65
pubmed: 24711448