Absorption and Intestinal Metabolic Profile of Oleocanthal in Rats.
bioavailability
extra virgin olive oil
in situ perfusion
metabolism
permeability
secoiridoids
Journal
Pharmaceutics
ISSN: 1999-4923
Titre abrégé: Pharmaceutics
Pays: Switzerland
ID NLM: 101534003
Informations de publication
Date de publication:
05 Feb 2020
05 Feb 2020
Historique:
received:
25
11
2019
revised:
25
01
2020
accepted:
30
01
2020
entrez:
9
2
2020
pubmed:
9
2
2020
medline:
9
2
2020
Statut:
epublish
Résumé
Oleocanthal (OLC), a phenolic compound of extra virgin olive oil (EVOO), has emerged as a potential therapeutic agent against a variety of diseases due to its anti-inflammatory activity. The aim of the present study is to explore its in vivo intestinal absorption and metabolism. An in situ perfusion technique in rats was used, involving simultaneous sampling from the luminal perfusate and mesenteric blood. Samples were analysed by UHPLC-MS-MS for the presence of oleocanthal (OLC) and its metabolites. OLC was mostly metabolized by phase I metabolism, undergoing hydration, hydrogenation and hydroxylation. Phase II reactions (glucuronidation of hydrogenated OLC and hydrated metabolites) were observed in plasma samples. OLC was poorly absorbed in the intestine, as indicated by the low effective permeability coefficient (2.23 ± 3.16 × 10
Identifiants
pubmed: 32033424
pii: pharmaceutics12020134
doi: 10.3390/pharmaceutics12020134
pmc: PMC7076358
pii:
doi:
Types de publication
Journal Article
Langues
eng
Commentaires et corrections
Type : ErratumIn
Déclaration de conflit d'intérêts
R.M.L.-R. reports receiving lecture fees from Cerveceros de España and receiving lecture fees and travel support from Adventia. The other authors declare no conflict of interest. The funders had no role in the design of the study; in the collection, analyses, or interpretation of data; in the writing of the manuscript, or in the decision to publish the results.
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