Patrick Augustijns

Affiliations

Drug Delivery and Disposition, KU Leuven, Gasthuisberg O&N II, Herestraat 49 - box 921, 3000, Leuven, Belgium. Electronic address: patrick.augustijns@kuleuven.be.

Publications (88)

Insight into the colonic disposition of celecoxib in humans.

European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences

Avec: Glenn Lemmens , Joachim Brouwers , Jan Snoeys , Patrick Augustijns , Tim Vanuytsel

Exploring the impact of real-life dosing conditions on intraluminal and systemic concentrations of atazanavir in parallel with gastric motility recording in healthy subjects.

European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V

Avec: Bart Hens , Imke Masuy , Eveline Deloose , Raf Mols , Jan Tack , Patrick Augustijns

Co-existing colloidal phases of human duodenal aspirates: Intraindividual fluctuations and interindividual variability in relation to molecular composition.

Journal of pharmaceutical and biomedical analysis

Avec: Philipp A Elvang , Mette Sloth Bohsen , Paul C Stein , Annette Bauer-Brandl , Danny Riethorst , Joachim Brouwers , Patrick Augustijns , Martin Brandl

The mechanisms of pharmacokinetic food-drug interactions - A perspective from the UNGAP group.

European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences

Avec: Mirko Koziolek , Stefano Alcaro , Patrick Augustijns , Abdul W Basit , Michael Grimm , Bart Hens , Caroline L Hoad , Philipp Jedamzik , Christine M Madla , Marc Maliepaard , Luca Marciani , Annalisa Maruca , Neil Parrott , Petr Pávek , Christopher J H Porter , Christos Reppas , Diana van Riet-Nales , Jari Rubbens , Marina Statelova , Natalie L Trevaskis , Kateřina Valentová , Maria Vertzoni , Dubravka Vitali Čepo , Maura Corsetti

Successful oral delivery of poorly water-soluble drugs both depends on the intraluminal behavior of drugs and of appropriate advanced drug delivery systems.

European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences

Avec: Ben J Boyd , Christel A S Bergström , Zahari Vinarov , Martin Kuentz , Joachim Brouwers , Patrick Augustijns , Martin Brandl , Andreas Bernkop-Schnürch , Neha Shrestha , Véronique Préat , Anette Müllertz , Annette Bauer-Brandl , Vincent Jannin

Favipiravir at high doses has potent antiviral activity in SARS-CoV-2-infected hamsters, whereas hydroxychloroquine lacks activity.

Proceedings of the National Academy of Sciences of the United States of America

Avec: Suzanne J F Kaptein , Sofie Jacobs , Lana Langendries , Laura Seldeslachts , Sebastiaan Ter Horst , Laurens Liesenborghs , Bart Hens , Valentijn Vergote , Elisabeth Heylen , Karine Barthelemy , Elke Maas , Carolien De Keyzer , Lindsey Bervoets , Jasper Rymenants , Tina Van Buyten , Xin Zhang , Rana Abdelnabi , Juanita Pang , Rachel Williams , Hendrik Jan Thibaut , Kai Dallmeier , Robbert Boudewijns , Jens Wouters , Patrick Augustijns , Nick Verougstraete , Christopher Cawthorne , Judith Breuer , Caroline Solas , Birgit Weynand , Pieter Annaert , Isabel Spriet , Greetje Vande Velde , Johan Neyts , Joana Rocha-Pereira , Leen Delang

Six years of progress in the oral biopharmaceutics area - A summary from the IMI OrBiTo project.

European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V

Avec: B Abrahamsson , M McAllister , P Augustijns , P Zane , J Butler , R Holm , P Langguth , A Lindahl , A Müllertz , X Pepin , A Rostami-Hodjegan , E Sjögren , M Berntsson , H Lennernäs

UNGAP best practice for improving solubility data quality of orally administered drugs.

European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences

Avec: M Vertzoni , J Alsenz , P Augustijns , A Bauer-Brandl , Cas Bergström , J Brouwers , A Müllerz , G Perlovich , C Saal , K Sugano , C Reppas

Integration of advanced methods and models to study drug absorption and related processes: An UNGAP perspective.

European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences

Avec: Clive G Wilson , Leon Aarons , Patrick Augustijns , Joachim Brouwers , Adam S Darwich , Tom De Waal , Grzegorz Garbacz , Simone Hansmann , Dagmara Hoc , Anela Ivanova , Mirko Koziolek , Christos Reppas , Philipp Schick , Maria Vertzoni , J Arturo García-Horsman

The impact of inflammation on the expression of drug transporters and metabolic enzymes in colonic tissue from ulcerative colitis patients.

International journal of pharmaceutics

Avec: Tom de Waal , Niklas Handin , Joachim Brouwers , Marc Ferrante , Séverine Vermeire , Tim Vanuytsel , Per Artursson , Patrick Augustijns

Tofacitinib in Pregnancy: Assessing Pregnancy and Infant Outcomes, Cord Blood, and Breast Milk Concentrations.

Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association

Avec: Katarina Mitrova , Mette Julsgaard , Patrick Augustijns , Karin Cerna , Uma Mahadevan , Dana Duricova , Auteur inconnu

Dissolution, phase behavior and mass transport of amorphous solid dispersions in aspirated human intestinal fluids.

Journal of pharmaceutical sciences

Avec: Ahmed Elkhabaz , Dana E Moseson , Joachim Brouwers , Patrick Augustijns , Lynne S Taylor

Insight into the Colonic Disposition of Sulindac in Humans.

Journal of pharmaceutical sciences

Avec: Glenn Lemmens , Joachim Brouwers , Jan Snoeys , Patrick Augustijns , Tim Vanuytsel

Current challenges and future perspectives in oral absorption research: An opinion of the UNGAP network.

Advanced drug delivery reviews

Avec: Zahari Vinarov , Bertil Abrahamsson , Per Artursson , Hannah Batchelor , Philippe Berben , Andreas Bernkop-Schnürch , James Butler , Jens Ceulemans , Nigel Davies , Didier Dupont , Gøril Eide Flaten , Nikoletta Fotaki , Brendan T Griffin , Vincent Jannin , Janneke Keemink , Filippos Kesisoglou , Mirko Koziolek , Martin Kuentz , Alan Mackie , Antonio J Meléndez-Martínez , Mark McAllister , Anette Müllertz , Caitriona M O'Driscoll , Neil Parrott , Jadwiga Paszkowska , Petr Pavek , Christopher J H Porter , Christos Reppas , Cordula Stillhart , Kiyohiko Sugano , Elena Toader , Kateřina Valentová , Maria Vertzoni , Saskia N De Wildt , Clive G Wilson , Patrick Augustijns

Adaptations in gastrointestinal physiology after sleeve gastrectomy and Roux-en-Y gastric bypass.

The lancet. Gastroenterology & hepatology

Avec: Nele Steenackers , Tim Vanuytsel , Patrick Augustijns , Jan Tack , Ann Mertens , Matthias Lannoo , Bart Van der Schueren , Christophe Matthys

Correction: López-Yerena, A., et al. "Absorption and Intestinal Metabolic Profile of Oleocanthal in Rats"

Pharmaceutics

Avec: Anallely López-Yerena , Anna Vallverdú-Queralt , Raf Mols , Patrick Augustijns , Rosa M Lamuela-Raventós , Elvira Escribano-Ferrer

Impact of gastrointestinal tract variability on oral drug absorption and pharmacokinetics: An UNGAP review.

European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences

Avec: Zahari Vinarov , Mohammad Abdallah , José A G Agundez , Karel Allegaert , Abdul W Basit , Marlies Braeckmans , Jens Ceulemans , Maura Corsetti , Brendan T Griffin , Michael Grimm , Daniel Keszthelyi , Mirko Koziolek , Christine M Madla , Christophe Matthys , Laura E McCoubrey , Amitava Mitra , Christos Reppas , Jef Stappaerts , Nele Steenackers , Natalie L Trevaskis , Tim Vanuytsel , Maria Vertzoni , Werner Weitschies , Clive Wilson , Patrick Augustijns

Fasted and fed state human duodenal fluids: Characterization, drug solubility, and comparison to simulated fluids and with human bioavailability.

European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V

Avec: D Dahlgren , M Venczel , J-P Ridoux , C Skjöld , A Müllertz , R Holm , P Augustijns , P M Hellström , H Lennernäs

Drug Disposition in the Lower Gastrointestinal Tract: Targeting and Monitoring.

Pharmaceutics

Avec: Glenn Lemmens , Arno Van Camp , Stephanie Kourula , Tim Vanuytsel , Patrick Augustijns

Predicting iron absorption from an effervescent iron supplement in obese patients before and after Roux-en-Y gastric bypass: a preliminary study.

Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS)

Avec: Ina Gesquiere , Nele Steenackers , Matthias Lannoo , Veerle Foulon , Ann Mertens , Ann Gils , Jan de Hoon , Patrick Augustijns , Christophe Matthys , Bart Van der Schueren

Molecular Dynamics Simulations on Interindividual Variability of Intestinal Fluids: Impact on Drug Solubilization.

Molecular pharmaceutics

Avec: Albin Parrow , Per Larsson , Patrick Augustijns , Christel A S Bergström

Exploring the Effect of Esomeprazole on Gastric and Duodenal Fluid Volumes and Absorption of Ritonavir.

Pharmaceutics

Avec: Tom de Waal , Jari Rubbens , Michael Grimm , Vincent Vandecaveye , Jan Tack , Werner Weitschies , Joachim Brouwers , Patrick Augustijns

Development of a HILIC-MS/MS method for the quantification of histamine and its main metabolites in human urine samples.

Talanta

Avec: Maxim Nelis , Lisse Decraecker , Guy Boeckxstaens , Patrick Augustijns , Deirdre Cabooter

Understanding the gastrointestinal tract in obesity: From gut motility patterns to enzyme secretion.

Neurogastroenterology and motility

Avec: Nele Steenackers , Gabriel Eksteen , Lucas Wauters , Patrick Augustijns , Bart Van der Schueren , Tim Vanuytsel , Christophe Matthys

The Dynamic Intestinal Absorption Model (Diamod®), an

International journal of pharmaceutics: X

Avec: Frédéric Moens , Gies Vandevijver , Anke De Blaiser , Adam Larsson , Fabio Spreafico , Patrick Augustijns , Massimo Marzorati

The effect of reduced gastric acid secretion on the gastrointestinal disposition of a ritonavir amorphous solid dispersion in fasted healthy volunteers: an in vivo - in vitro investigation.

European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences

Avec: Jens Van Den Abeele , Christina Kostantini , Richard Barker , Alexandros Kourentas , James C Mann , Maria Vertzoni , Stefania Beato , Christos Reppas , Jan Tack , Patrick Augustijns

Impact of gastrointestinal physiology on drug absorption in special populations--An UNGAP review.

European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences

Avec: Cordula Stillhart , Katarina Vučićević , Patrick Augustijns , Abdul W Basit , Hannah Batchelor , Talia R Flanagan , Ina Gesquiere , Rick Greupink , Daniel Keszthelyi , Mikko Koskinen , Christine M Madla , Christophe Matthys , Goran Miljuš , Miriam G Mooij , Neil Parrott , Anna-Lena Ungell , Saskia N de Wildt , Mine Orlu , Sandra Klein , Anette Müllertz

Codeine delays gastric emptying through inhibition of gastric motility as assessed with a novel diagnostic intragastric balloon catheter.

Neurogastroenterology and motility

Avec: Nick Goelen , Jan de Hoon , John F Morales , Carolina Varon , Sabine Van Huffel , Patrick Augustijns , Raf Mols , Marissa Herbots , Kristin Verbeke , Tim Vanuytsel , Jan Tack , Pieter Janssen

Interplay of Supersaturation and Solubilization: Lack of Correlation between Concentration-Based Supersaturation Measurements and Membrane Transport Rates in Simulated and Aspirated Human Fluids.

Molecular pharmaceutics

Avec: Ahmed Elkhabaz , Dana E Moseson , Joachim Brouwers , Patrick Augustijns , Lynne S Taylor

Immobilizing sulfotransferase 1A1 on magnetic microparticles and their evaluation using capillary electrophoresis.

Electrophoresis

Avec: Pranov Ramana , Erwin Adams , Patrick Augustijns , Ann Van Schepdael

Impact of regional differences along the gastrointestinal tract of healthy adults on oral drug absorption: An UNGAP review.

European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences

Avec: Maria Vertzoni , Patrick Augustijns , Michael Grimm , Mirko Koziolek , Glenn Lemmens , Neil Parrott , Christina Pentafragka , Christos Reppas , Jari Rubbens , Jens Van Den Αbeele , Tim Vanuytsel , Werner Weitschies , Clive G Wilson

In vitro models for the prediction of in vivo performance of oral dosage forms: Recent progress from partnership through the IMI OrBiTo collaboration.

European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V

Avec: James Butler , Bart Hens , Maria Vertzoni , Joachim Brouwers , Philippe Berben , Jennifer Dressman , Cord J Andreas , Kerstin Julia Schaefer , James Mann , Mark McAllister , Masoud Jamei , Edmund Kostewicz , Filippos Kesisoglou , Peter Langguth , Mans Minekus , Anette Müllertz , Ronald Schilderink , Mirko Koziolek , Philipp Jedamzik , Werner Weitschies , Christos Reppas , Patrick Augustijns

Preoperative administration of the 5-HT4 receptor agonist prucalopride reduces intestinal inflammation and shortens postoperative ileus via cholinergic enteric neurons.

Gut

Avec: Nathalie Stakenborg , Evelien Labeeuw , Pedro J Gomez-Pinilla , Sebastiaan De Schepper , Raymond Aerts , Gera Goverse , Giovanna Farro , Iris Appeltans , Elisa Meroni , Michelle Stakenborg , Maria Francesca Viola , Erika Gonzalez-Dominguez , Goele Bosmans , Yeranddy A Alpizar , Albert Wolthuis , Andre D'Hoore , Kim Van Beek , Simon Verheijden , Marleen Verhaegen , Rita Derua , Etienne Waelkens , Milena Moretti , Cecilia Gotti , Patrick Augustijns , Karel Talavera , Pieter Vanden Berghe , Gianluca Matteoli , Guy E Boeckxstaens

Duodenal Dysbiosis and Relation to the Efficacy of Proton Pump Inhibitors in Functional Dyspepsia.

International journal of molecular sciences

Avec: Lucas Wauters , Raúl Y Tito , Matthias Ceulemans , Maarten Lambaerts , Alison Accarie , Leen Rymenans , Chloë Verspecht , Joran Toth , Raf Mols , Patrick Augustijns , Jan Tack , Tim Vanuytsel , Jeroen Raes

Fasted intestinal solubility limits and distributions applied to the biopharmaceutics and developability classification systems.

European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V

Avec: Qamar Abuhassan , Ibrahim Khadra , Kate Pyper , Patrick Augustijns , Joachim Brouwers , Gavin W Halbert

Leveraging Oral Drug Development to a Next Level: Impact of the IMI-Funded OrBiTo Project on Patient Healthcare.

Frontiers in medicine

Avec: Bart Hens , Patrick Augustijns , Hans Lennernäs , Mark McAllister , Bertil Abrahamsson

An Assessment of Occasional Bio-Inequivalence for BCS1 and BCS3 Drugs: What are the Underlying Reasons?

Journal of pharmaceutical sciences

Avec: James Butler , Patrick Augustijns

The oral protease inhibitor (PF-07321332) protects Syrian hamsters against infection with SARS-CoV-2 variants of concern.

Nature communications

Avec: Rana Abdelnabi , Caroline S Foo , Dirk Jochmans , Laura Vangeel , Steven De Jonghe , Patrick Augustijns , Raf Mols , Birgit Weynand , Thanaporn Wattanakul , Richard M Hoglund , Joel Tarning , Charles E Mowbray , Peter Sjö , Fanny Escudié , Ivan Scandale , Eric Chatelain , Johan Neyts

Application of In Vivo Imaging Techniques and Diagnostic Tools in Oral Drug Delivery Research.

Pharmaceutics

Avec: Stefan Senekowitsch , Philipp Schick , Bertil Abrahamsson , Patrick Augustijns , Thomas Gießmann , Hans Lennernäs , Christophe Matthys , Luca Marciani , Xavier Pepin , Alan Perkins , Maximilian Feldmüller , Sarah Sulaiman , Werner Weitschies , Clive G Wilson , Maura Corsetti , Mirko Koziolek

Molecular Dynamics Simulations of Self-Assembling Colloids in Fed-State Human Intestinal Fluids and Their Solubilization of Lipophilic Drugs.

Molecular pharmaceutics

Avec: Albin Parrow , Per Larsson , Patrick Augustijns , Christel A S Bergström

Characterization of neonatal and infant enterostomy fluids.

International journal of pharmaceutics

Avec: Tom de Waal , Joachim Brouwers , Raf Mols , Ilse Hoffman , Maissa Rayyan , Patrick Augustijns

Expression of intestinal drug transporter proteins and metabolic enzymes in neonatal and pediatric patients.

International journal of pharmaceutics

Avec: Tom de Waal , Niklas Handin , Joachim Brouwers , Marc Miserez , Ilse Hoffman , Maissa Rayyan , Per Artursson , Patrick Augustijns

Characterization of luminal contents from the fasted human proximal colon.

European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences

Avec: Sebastian Steigert , Joachim Brouwers , Kristin Verbeke , Tim Vanuytsel , Patrick Augustijns

Unraveling the behavior of oral drug products inside the human gastrointestinal tract using the aspiration technique: History, methodology and applications.

European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences

Avec: Patrick Augustijns , Maria Vertzoni , Christos Reppas , Peter Langguth , Hans Lennernäs , Bertil Abrahamsson , William L Hasler , Jason R Baker , Tim Vanuytsel , Jan Tack , Maura Corsetti , Marival Bermejo , Paulo Paixão , Gordon L Amidon , Bart Hens

Absorption and Intestinal Metabolic Profile of Oleocanthal in Rats.

Pharmaceutics

Avec: Anallely López-Yerena , Anna Vallverdú-Queralt , Raf Mols , Patrick Augustijns , Rosa M Lamuela-Raventós , Elvira Escribano-Ferrer

The influence of gastric motility on the intraluminal behavior of fosamprenavir.

European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences

Avec: Marlies Braeckmans , Joachim Brouwers , Imke Masuy , Cécile Servais , Jan Tack , Patrick Augustijns

Best practices in current models mimicking drug permeability in the gastrointestinal tract - An UNGAP review.

European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences

Avec: Joseph P O'Shea , Patrick Augustijns , Martin Brandl , David J Brayden , Joachim Brouwers , Brendan T Griffin , René Holm , Ann-Christin Jacobsen , Hans Lennernäs , Zahari Vinarov , Caitriona M O'Driscoll

Codeine induces increased resistance at the esophagogastric junction but has no effect on motility and bolus flow in the pharynx and upper esophageal sphincter in healthy volunteers: A randomized, double-blind, placebo-controlled, cross-over trial.

Neurogastroenterology and motility

Avec: Annelies Geeraerts , Hannelore Geysen , Lisa Ballet , Claudia Hofmans , Egbert Clevers , Taher Omari , Anastassios C Manolakis , Raf Mols , Patrick Augustijns , Tim Vanuytsel , Nathalie Rommel , Jan Tack , Ans Pauwels

Exploring the Impact of Intestinal Fluid Components on the Solubility and Supersaturation of Danazol.

Journal of pharmaceutical sciences

Avec: Cecilie Maria Madsen , Jakob Plum , Bart Hens , Patrick Augustijns , Anette Müllertz , Thomas Rades

Reply to "Comment on López-Yerena et al. 'Absorption and Intestinal Metabolic Profile of Oleocanthal in Rats'

Pharmaceutics

Avec: Anallely López-Yerena , Anna Vallverdú-Queralt , Raf Mols , Patrick Augustijns , Rosa M Lamuela-Raventós , Elvira Escribano-Ferrer

Erratum: Hens, B.; et al. Application of the Gastrointestinal Simulator (GIS) Coupled with In Silico Modeling to Measure the Impact of Coca-Cola

Pharmaceutics

Avec: Bart Hens , Marival Bermejo , Patrick Augustijns , Rodrigo Cristofoletti , Gregory E Amidon , Gordon L Amidon

The effect of esomeprazole on the upper GI tract release and systemic absorption of mesalazine from colon targeted formulations.

International journal of pharmaceutics

Avec: Arno Van Camp , Tim Vanuytsel , Joachim Brouwers , Patrick Augustijns

Structured solubility behaviour in bioequivalent fasted simulated intestinal fluids.

European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V

Avec: Qamar Abuhassan , Ibrahim Khadra , Kate Pyper , Patrick Augustijns , Joachim Brouwers , Gavin W Halbert

Investigating the Mechanisms behind the Positive Food Effect of Abiraterone Acetate: In Vitro and Rat In Situ Studies.

Pharmaceutics

Avec: Marlies Braeckmans , Patrick Augustijns , Raf Mols , Cécile Servais , Joachim Brouwers

Effect of obesity on gastrointestinal transit, pressure and pH using a wireless motility capsule.

European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V

Avec: N Steenackers , L Wauters , B Van der Schueren , P Augustijns , G Falony , M Koziolek , M Lannoo , A Mertens , A Meulemans , J Raes , R Vangoitsenhoven , S Vieira-Silva , W Weitschies , C Matthys , T Vanuytsel

The combined treatment of Molnupiravir and Favipiravir results in a potentiation of antiviral efficacy in a SARS-CoV-2 hamster infection model.

EBioMedicine

Avec: Rana Abdelnabi , Caroline S Foo , Suzanne J F Kaptein , Xin Zhang , Thuc Nguyen Dan Do , Lana Langendries , Laura Vangeel , Judith Breuer , Juanita Pang , Rachel Williams , Valentijn Vergote , Elisabeth Heylen , Pieter Leyssen , Kai Dallmeier , Lotte Coelmont , Arnab K Chatterjee , Raf Mols , Patrick Augustijns , Steven De Jonghe , Dirk Jochmans , Birgit Weynand , Johan Neyts

β-D-N

Antiviral research

Avec: Ana Lucia Rosales-Rosas , Alina Soto , Lanjiao Wang , Raf Mols , Albin Fontaine , Aboubakar Sanon , Patrick Augustijns , Leen Delang

Challenges in Permeability Assessment for Oral Drug Product Development.

Pharmaceutics

Avec: Mirko Koziolek , Patrick Augustijns , Constantin Berger , Rodrigo Cristofoletti , David Dahlgren , Janneke Keemink , Pär Matsson , Fiona McCartney , Marco Metzger , Mario Mezler , Janis Niessen , James E Polli , Maria Vertzoni , Werner Weitschies , Jennifer Dressman

Physiologically based pharmacokinetic (PBPK) modelling of oral drug absorption in older adults - an AGePOP review.

European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences

Avec: Cleo Demeester , Donnia Robins , Angela Elma Edwina , Jos Tournoy , Patrick Augustijns , Ibrahim Ince , Andreas Lehmann , Maria Vertzoni , Jan Frederik Schlender

Drug Dissolution in Oral Drug Absorption: Workshop Report.

The AAPS journal

Avec: Kimberly Raines , Payal Agarwal , Patrick Augustijns , Alaadin Alayoubi , Lucas Attia , Annette Bauer-Brandl , Martin Brandl , Parnali Chatterjee , Hansong Chen , Yuly Chiang Yu , Carrie Coutant , Ana Luisa Coutinho , David Curran , Jennifer Dressman , Bryan Ericksen , Leah Falade , Yi Gao , Zongming Gao , Debasis Ghosh , Tapash Ghosh , Anitha Govada , Elizabeth Gray , Ruiqiong Guo , Dana Hammell , Andre Hermans , Rohit Jaini , Hanlin Li , Haritha Mandula , Shuaiqian Men , Johanna Milsmann , Huong Moldthan , Rebecca Moody , Dana E Moseson , Anette Müllertz , Roshni Patel , Kalpana Paudel , Christos Reppas , Rajesh Savkur , Kerstin Schaefer , Abu Serajuddin , Lynne S Taylor , Rutu Valapil , Kevin Wei , Werner Weitschies , Shinji Yamashita , James E Polli

Enzymatic prodrug degradation in the fasted and fed small intestine: In vitro studies and interindividual variability in human aspirates.

International journal of pharmaceutics

Avec: Zahari Vinarov , Christophe Tistaert , Jan Bevernage , Hugo Bohets , Patrick Augustijns

Correction: Van der Veken et al. Gastrointestinal Fluid Volumes in Pediatrics: A Retrospective MRI Study.

Pharmaceutics

Avec: Matthias Van der Veken , Michael Aertsen , Joachim Brouwers , Cordula Stillhart , Neil Parrott , Patrick Augustijns

Physiologically based biopharmaceutics modeling of regional and colon absorption in humans.

European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V

Avec: Christer Tannergren , Harshad Jadhav , Emma Eckernäs , Jonas Fagerberg , Patrick Augustijns , Erik Sjögren

The effect of sparkling water on the systemic pharmacokinetics of paracetamol in older adults.

International journal of pharmaceutics

Avec: Fritz Harder , Malissa Bresseleers , Joachim Brouwers , Tim Vanuytsel , Patrick Augustijns

Drug metabolism and disposition: the biological fate of chemicals

Avec: Sarinj Fattah , Abhijit Babaji Shinde , Myriam Baes , Karel Allegaert , Patrick Augustijns , Pieter Annaert

Biorelevant dissolution testing of a weak base: Interlaboratory reproducibility and investigation of parameters controlling in vitro precipitation.

European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V

Avec: Philippe Berben , Lee Ashworth , Stefania Beato , Jan Bevernage , Jean-Luc Bruel , James Butler , Jennifer Dressman , Kerstin Schäfer , Paul Hutchins , Lukas Klumpp , James Mann , Janine Nicolai , Krista Ojala , Sanjaykumar Patel , Sarah Powell , Karin Rosenblatt , Irena Tomaszewska , James Williams , Patrick Augustijns

Gastric and Duodenal Diclofenac Concentrations in Healthy Volunteers after Intake of the FDA Standard Meal: In Vivo Observations and in Vitro Explorations.

Molecular pharmaceutics

Avec: Jari Rubbens , Joachim Brouwers , Jan Tack , Patrick Augustijns

The effect of chitosan on the bioaccessibility and intestinal permeability of acyclovir.

European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V

Avec: Marlies Kubbinga , Patrick Augustijns , Mauricio A García , Christian Heinen , Heleen M Wortelboer , Miriam Verwei , Peter Langguth

Intestinal phase-II metabolism of quercetin in HT29 cells, 3D human intestinal tissues and in healthy volunteers: a qualitative comparison using LC-IMS-MS and LC-HRMS.

Xenobiotica; the fate of foreign compounds in biological systems

Avec: Clément Chalet , Boudewijn Hollebrands , Guus S Duchateau , Patrick Augustijns

Relationship between bile salts, bacterial translocation, and duodenal mucosal integrity in functional dyspepsia.

Neurogastroenterology and motility

Avec: Dorien Beeckmans , Ricard Farré , Danny Riethorst , Åsa V Keita , Patrick Augustijns , Johan D Söderholm , Tim Vanuytsel , Hanne Vanheel , Jan Tack

Biorelevant Two-Stage In Vitro Testing for rDCS Classification and in PBPK Modeling-Case Example Ritonavir.

Journal of pharmaceutical sciences

Avec: Tom Fiolka , Jens Van Den Abeele , Patrick Augustijns , Sumit Arora , Jennifer Dressman

Multidimensional analysis of human intestinal fluid composition.

European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V

Avec: Kate Pyper , Joachim Brouwers , Patrick Augustijns , I Khadra , C Dunn , C G Wilson , G W Halbert

Chloroquine, an Anti-Malaria Drug as Effective Prevention for Hantavirus Infections.

Frontiers in cellular and infection microbiology

Avec: Valentijn Vergote , Lies Laenen , Raf Mols , Patrick Augustijns , Marc Van Ranst , Piet Maes

Local immune response to food antigens drives meal-induced abdominal pain.

Nature

Avec: Javier Aguilera-Lizarraga , Morgane V Florens , Maria Francesca Viola , Piyush Jain , Lisse Decraecker , Iris Appeltans , Maria Cuende-Estevez , Naomi Fabre , Kim Van Beek , Eluisa Perna , Dafne Balemans , Nathalie Stakenborg , Stavroula Theofanous , Goele Bosmans , Stéphanie U Mondelaers , Gianluca Matteoli , Sales Ibiza Martínez , Cintya Lopez-Lopez , Josue Jaramillo-Polanco , Karel Talavera , Yeranddy A Alpizar , Thorsten B Feyerabend , Hans-Reimer Rodewald , Ricard Farre , Frank A Redegeld , Jiyeon Si , Jeroen Raes , Christine Breynaert , Rik Schrijvers , Cédric Bosteels , Bart N Lambrecht , Scott D Boyd , Ramona A Hoh , Deirdre Cabooter , Maxim Nelis , Patrick Augustijns , Sven Hendrix , Jessica Strid , Raf Bisschops , David E Reed , Stephen J Vanner , Alexandre Denadai-Souza , Mira M Wouters , Guy E Boeckxstaens

Proton Pump Inhibitors Reduce Duodenal Eosinophilia, Mast Cells, and Permeability in Patients With Functional Dyspepsia.

Gastroenterology

Avec: Lucas Wauters , Matthias Ceulemans , Dennis Frings , Maarten Lambaerts , Alison Accarie , Joran Toth , Raf Mols , Patrick Augustijns , Gert De Hertogh , Lukas Van Oudenhove , Jan Tack , Tim Vanuytsel

The Influence of Fed State Lipolysis Inhibition on the Intraluminal Behaviour and Absorption of Fenofibrate from a Lipid-Based Formulation.

Pharmaceutics

Avec: Marlies Braeckmans , Joachim Brouwers , Danny Riethorst , Cécile Servais , Jan Tack , Patrick Augustijns

Orlistat disposition in the human jejunum and the effect of lipolysis inhibition on bile salt concentrations and composition.

International journal of pharmaceutics

Avec: Marlies Braeckmans , Joachim Brouwers , Raf Mols , Cécile Servais , Jan Tack , Patrick Augustijns

Practical and operational considerations related to paediatric oral drug formulation: An industry survey.

International journal of pharmaceutics

Avec: Matthias Van der Veken , Joachim Brouwers , Valérie Budts , Louis Lauwerys , Shriram M Pathak , Hannah Batchelor , Patrick Augustijns

Assessment of food effects during clinical development.

International journal of pharmaceutics

Avec: Zahari Vinarov , James Butler , Filippos Kesisoglou , Mirko Koziolek , Patrick Augustijns

The impact of advanced age on gastrointestinal characteristics that are relevant to oral drug absorption: An AGePOP review.

European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences

Avec: Cordula Stillhart , Adam Asteriadis , Ekaterina Bocharova , Gabriel Eksteen , Fritz Harder , Jonas Kusch , Theodora Tzakri , Patrick Augustijns , Christophe Matthys , Maria Vertzoni , Werner Weitschies , Christos Reppas

Avec: Nele Steenackers , Tim Vanuytsel , Patrick Augustijns , Ellen Deleus , Wies Deckers , Christophe M Deroose , Gwen Falony , Matthias Lannoo , Ann Mertens , Raf Mols , Roman Vangoitsenhoven , Lucas Wauters , Bart Van der Schueren , Christophe Matthys

Characterization of neonatal and infant enterostomy fluids - part II: Drug solubility.

International journal of pharmaceutics

Avec: Tom de Waal , Joachim Brouwers , Maissa Rayyan , Cordula Stillhart , Liliya Vinarova , Zahari Vinarov , Patrick Augustijns

Investigating Tacrolimus Disposition in Paediatric Patients with a Physiologically Based Pharmacokinetic Model Incorporating CYP3A4 Ontogeny, Mechanistic Absorption and Red Blood Cell Binding.

Pharmaceutics

Avec: Matthias Van der Veken , Joachim Brouwers , Agustos Cetin Ozbey , Kenichi Umehara , Cordula Stillhart , Noël Knops , Patrick Augustijns , Neil John Parrott

Approaches to Account for Colon Absorption in Physiologically Based Biopharmaceutics Modeling of Extended-Release Drug Products.

Molecular pharmaceutics

Avec: Harshad Jadhav , Patrick Augustijns , Christer Tannergren

A quantification of gastric and duodenal fluid volumes in older adults using MRI.

International journal of pharmaceutics

Avec: Cleo Demeester , Matthias Van der Veken , Joachim Brouwers , Ragna Vanslembrouck , André Dallmann , Thomas Wendl , Patrick Augustijns

Réseau de co-auteurs

Joachim Brouwers 31 collaborations

Tim Vanuytsel 20 collaborations

Raf Mols 16 collaborations

Jan Tack 15 collaborations

Maria Vertzoni 11 collaborations

Christos Reppas 10 collaborations

Mirko Koziolek 9 collaborations

Christophe Matthys 9 collaborations

Bart Hens 8 collaborations

Werner Weitschies 8 collaborations

Zahari Vinarov 7 collaborations

Cordula Stillhart 7 collaborations

Neil Parrott 6 collaborations

Anette Müllertz 6 collaborations

Tom de Waal 6 collaborations

Nele Steenackers 6 collaborations

James Butler 5 collaborations

Bart Van der Schueren 5 collaborations

Marlies Braeckmans 5 collaborations

Jennifer Dressman 5 collaborations

Matthias Van der Veken 5 collaborations

Glenn Lemmens 4 collaborations

Martin Brandl 4 collaborations

Michael Grimm 4 collaborations

Jari Rubbens 4 collaborations

Maura Corsetti 4 collaborations

P Augustijns 4 collaborations

Clive G Wilson 4 collaborations

Bertil Abrahamsson 4 collaborations

Philippe Berben 4 collaborations

Lucas Wauters 4 collaborations

Hans Lennernäs 4 collaborations

Cécile Servais 4 collaborations

Annette Bauer-Brandl 3 collaborations

Danny Riethorst 3 collaborations

Abdul W Basit 3 collaborations

Christine M Madla 3 collaborations

Christel A S Bergström 3 collaborations

Valentijn Vergote 3 collaborations

Rana Abdelnabi 3 collaborations

Birgit Weynand 3 collaborations

Johan Neyts 3 collaborations

Per Artursson 3 collaborations

Dana E Moseson 3 collaborations

Lynne S Taylor 3 collaborations

Hannah Batchelor 3 collaborations

Brendan T Griffin 3 collaborations

Filippos Kesisoglou 3 collaborations

Mark McAllister 3 collaborations

Ann Mertens 3 collaborations

Matthias Lannoo 3 collaborations

Anallely López-Yerena 3 collaborations

Anna Vallverdú-Queralt 3 collaborations

Rosa M Lamuela-Raventós 3 collaborations

Elvira Escribano-Ferrer 3 collaborations

Peter Langguth 3 collaborations

Kate Pyper 3 collaborations

Maissa Rayyan 3 collaborations

Jan Snoeys 2 collaborations

Imke Masuy 2 collaborations

Philipp Jedamzik 2 collaborations

Luca Marciani 2 collaborations

Christopher J H Porter 2 collaborations

Natalie L Trevaskis 2 collaborations

Kateřina Valentová 2 collaborations

Martin Kuentz 2 collaborations

Andreas Bernkop-Schnürch 2 collaborations

Vincent Jannin 2 collaborations

Suzanne J F Kaptein 2 collaborations

Lana Langendries 2 collaborations

Elisabeth Heylen 2 collaborations

Xin Zhang 2 collaborations

Juanita Pang 2 collaborations

Rachel Williams 2 collaborations

Kai Dallmeier 2 collaborations

Judith Breuer 2 collaborations

Pieter Annaert 2 collaborations

Leen Delang 2 collaborations

R Holm 2 collaborations

A Müllertz 2 collaborations

H Lennernäs 2 collaborations

Philipp Schick 2 collaborations

Niklas Handin 2 collaborations

Ahmed Elkhabaz 2 collaborations

Jens Ceulemans 2 collaborations

Janneke Keemink 2 collaborations

Caitriona M O'Driscoll 2 collaborations

Karel Allegaert 2 collaborations

Daniel Keszthelyi 2 collaborations

Arno Van Camp 2 collaborations

Ina Gesquiere 2 collaborations

Jan de Hoon 2 collaborations

Albin Parrow 2 collaborations

Per Larsson 2 collaborations

Maxim Nelis 2 collaborations

Lisse Decraecker 2 collaborations

Deirdre Cabooter 2 collaborations

Gabriel Eksteen 2 collaborations

Jens Van Den Abeele 2 collaborations

Stefania Beato 2 collaborations

Kristin Verbeke 2 collaborations

James Mann 2 collaborations

Nathalie Stakenborg 2 collaborations

Iris Appeltans 2 collaborations

Maria Francesca Viola 2 collaborations

Goele Bosmans 2 collaborations

Yeranddy A Alpizar 2 collaborations

Kim Van Beek 2 collaborations

Karel Talavera 2 collaborations

Gianluca Matteoli 2 collaborations

Guy E Boeckxstaens 2 collaborations

Matthias Ceulemans 2 collaborations

Maarten Lambaerts 2 collaborations

Alison Accarie 2 collaborations

Joran Toth 2 collaborations

Jeroen Raes 2 collaborations

Qamar Abuhassan 2 collaborations

Ibrahim Khadra 2 collaborations

Gavin W Halbert 2 collaborations

Caroline S Foo 2 collaborations

Dirk Jochmans 2 collaborations

Laura Vangeel 2 collaborations

Steven De Jonghe 2 collaborations

Ilse Hoffman 2 collaborations

Marival Bermejo 2 collaborations

Gordon L Amidon 2 collaborations

Rodrigo Cristofoletti 2 collaborations

James E Polli 2 collaborations

Cleo Demeester 2 collaborations

Jan Bevernage 2 collaborations

Michael Aertsen 2 collaborations

Christer Tannergren 2 collaborations

Harshad Jadhav 2 collaborations

Fritz Harder 2 collaborations

Eveline Deloose 1 collaboration

Philipp A Elvang 1 collaboration

Mette Sloth Bohsen 1 collaboration

Paul C Stein 1 collaboration

Stefano Alcaro 1 collaboration

Caroline L Hoad 1 collaboration

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Dubravka Vitali Čepo 1 collaboration

Ben J Boyd 1 collaboration

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Jasper Rymenants 1 collaboration

Tina Van Buyten 1 collaboration

Hendrik Jan Thibaut 1 collaboration

Robbert Boudewijns 1 collaboration

Jens Wouters 1 collaboration

Nick Verougstraete 1 collaboration

Christopher Cawthorne 1 collaboration

Caroline Solas 1 collaboration

Isabel Spriet 1 collaboration

Greetje Vande Velde 1 collaboration

Joana Rocha-Pereira 1 collaboration

B Abrahamsson 1 collaboration

M McAllister 1 collaboration

P Zane 1 collaboration

J Butler 1 collaboration

P Langguth 1 collaboration

A Lindahl 1 collaboration

X Pepin 1 collaboration

A Rostami-Hodjegan 1 collaboration

E Sjögren 1 collaboration

M Berntsson 1 collaboration

M Vertzoni 1 collaboration

J Alsenz 1 collaboration

A Bauer-Brandl 1 collaboration

Cas Bergström 1 collaboration

J Brouwers 1 collaboration

A Müllerz 1 collaboration

G Perlovich 1 collaboration

C Saal 1 collaboration

K Sugano 1 collaboration

C Reppas 1 collaboration

Leon Aarons 1 collaboration

Adam S Darwich 1 collaboration

Tom De Waal 1 collaboration

Grzegorz Garbacz 1 collaboration

Simone Hansmann 1 collaboration

Dagmara Hoc 1 collaboration

Anela Ivanova 1 collaboration

J Arturo García-Horsman 1 collaboration

Marc Ferrante 1 collaboration

Séverine Vermeire 1 collaboration

Katarina Mitrova 1 collaboration

Mette Julsgaard 1 collaboration

Karin Cerna 1 collaboration

Uma Mahadevan 1 collaboration

Dana Duricova 1 collaboration

None None 1 collaboration

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Didier Dupont 1 collaboration

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Nikoletta Fotaki 1 collaboration

Alan Mackie 1 collaboration

Antonio J Meléndez-Martínez 1 collaboration

Jadwiga Paszkowska 1 collaboration

Petr Pavek 1 collaboration

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Elena Toader 1 collaboration

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Mohammad Abdallah 1 collaboration

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Clive Wilson 1 collaboration

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Ann Gils 1 collaboration

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Mine Orlu 1 collaboration

Sandra Klein 1 collaboration

Nick Goelen 1 collaboration

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Carolina Varon 1 collaboration

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Kerstin Julia Schaefer 1 collaboration

Masoud Jamei 1 collaboration

Edmund Kostewicz 1 collaboration

Mans Minekus 1 collaboration

Ronald Schilderink 1 collaboration

Evelien Labeeuw 1 collaboration

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Raymond Aerts 1 collaboration

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Milena Moretti 1 collaboration

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Pieter Vanden Berghe 1 collaboration

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Leen Rymenans 1 collaboration

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Thanaporn Wattanakul 1 collaboration

Richard M Hoglund 1 collaboration

Joel Tarning 1 collaboration

Charles E Mowbray 1 collaboration

Peter Sjö 1 collaboration

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Ivan Scandale 1 collaboration

Eric Chatelain 1 collaboration

Stefan Senekowitsch 1 collaboration

Thomas Gießmann 1 collaboration

Xavier Pepin 1 collaboration

Alan Perkins 1 collaboration

Maximilian Feldmüller 1 collaboration

Sarah Sulaiman 1 collaboration

Marc Miserez 1 collaboration

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William L Hasler 1 collaboration

Jason R Baker 1 collaboration

Paulo Paixão 1 collaboration

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David J Brayden 1 collaboration

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Taher Omari 1 collaboration

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Nathalie Rommel 1 collaboration

Ans Pauwels 1 collaboration

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Jakob Plum 1 collaboration

Thomas Rades 1 collaboration

Gregory E Amidon 1 collaboration

N Steenackers 1 collaboration

L Wauters 1 collaboration

B Van der Schueren 1 collaboration

G Falony 1 collaboration

M Koziolek 1 collaboration

M Lannoo 1 collaboration

A Mertens 1 collaboration

A Meulemans 1 collaboration

J Raes 1 collaboration

R Vangoitsenhoven 1 collaboration

S Vieira-Silva 1 collaboration

W Weitschies 1 collaboration

C Matthys 1 collaboration

T Vanuytsel 1 collaboration

Thuc Nguyen Dan Do 1 collaboration

Pieter Leyssen 1 collaboration

Lotte Coelmont 1 collaboration

Arnab K Chatterjee 1 collaboration

Ana Lucia Rosales-Rosas 1 collaboration

Alina Soto 1 collaboration

Lanjiao Wang 1 collaboration

Albin Fontaine 1 collaboration

Aboubakar Sanon 1 collaboration

Constantin Berger 1 collaboration

David Dahlgren 1 collaboration

Pär Matsson 1 collaboration

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Jos Tournoy 1 collaboration

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Kimberly Raines 1 collaboration

Payal Agarwal 1 collaboration

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Lucas Attia 1 collaboration

Parnali Chatterjee 1 collaboration

Hansong Chen 1 collaboration

Yuly Chiang Yu 1 collaboration

Carrie Coutant 1 collaboration

Ana Luisa Coutinho 1 collaboration

David Curran 1 collaboration

Bryan Ericksen 1 collaboration

Leah Falade 1 collaboration

Yi Gao 1 collaboration

Zongming Gao 1 collaboration

Debasis Ghosh 1 collaboration

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Elizabeth Gray 1 collaboration

Ruiqiong Guo 1 collaboration

Dana Hammell 1 collaboration

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Hanlin Li 1 collaboration

Haritha Mandula 1 collaboration

Shuaiqian Men 1 collaboration

Johanna Milsmann 1 collaboration

Huong Moldthan 1 collaboration

Rebecca Moody 1 collaboration

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Kevin Wei 1 collaboration

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Sarah Powell 1 collaboration

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James Williams 1 collaboration

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Mauricio A García 1 collaboration

Christian Heinen 1 collaboration

Heleen M Wortelboer 1 collaboration

Miriam Verwei 1 collaboration

Clément Chalet 1 collaboration

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Dorien Beeckmans 1 collaboration

Ricard Farré 1 collaboration

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Johan D Söderholm 1 collaboration

Hanne Vanheel 1 collaboration

Tom Fiolka 1 collaboration

Sumit Arora 1 collaboration

I Khadra 1 collaboration

C Dunn 1 collaboration

C G Wilson 1 collaboration

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Lies Laenen 1 collaboration

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Thomas Wendl 1 collaboration