Effect of obesity on gastrointestinal transit, pressure and pH using a wireless motility capsule.
Food effect
Gastrointestinal pH
Gastrointestinal physiology
Gastrointestinal pressure
Gastrointestinal transit time
Obesity
Wireless motility capsule
Journal
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V
ISSN: 1873-3441
Titre abrégé: Eur J Pharm Biopharm
Pays: Netherlands
ID NLM: 9109778
Informations de publication
Date de publication:
Oct 2021
Oct 2021
Historique:
received:
13
04
2021
revised:
22
06
2021
accepted:
07
07
2021
pubmed:
18
7
2021
medline:
13
1
2022
entrez:
17
7
2021
Statut:
ppublish
Résumé
Despite the increasing prevalence and medical burden of obesity, the understanding of gastrointestinal physiology in obesity is scarce, which hampers drug development. To investigate the effect of obesity and food intake on gastrointestinal transit, pressure and pH. An exploratory cross-sectional study using a wireless motility capsule (SmartPill©) was performed in 11 participants with obesity and 11 age- and gender-matched participants with normal weight (group) in fasted and fed state (visit). During the first visit, the capsule was ingested after an overnight fast. During a second visit, the capsule was ingested after a nutritional drink to simulate fed state. Linear mixed models were constructed to compare segmental gastrointestinal transit, pressure and pH between groups (obesity or control) and within every group (fasted or fed). Food intake slowed gastric emptying in both groups (both P < 0.0001), though food-induced gastric contractility was higher in participants with obesity compared to controls (P = 0.02). In the small intestine, a higher contractility (P = 0.001), shorter transit (P = 0.04) and lower median pH (P = 0.002) was observed in participants with obesity compared to controls. No differences were observed for colonic measurements. Obesity has a profound impact on gastrointestinal physiology, which should be taken into account for drug development.
Sections du résumé
BACKGROUND
BACKGROUND
Despite the increasing prevalence and medical burden of obesity, the understanding of gastrointestinal physiology in obesity is scarce, which hampers drug development.
AIM
OBJECTIVE
To investigate the effect of obesity and food intake on gastrointestinal transit, pressure and pH.
MATERIAL AND METHODS
METHODS
An exploratory cross-sectional study using a wireless motility capsule (SmartPill©) was performed in 11 participants with obesity and 11 age- and gender-matched participants with normal weight (group) in fasted and fed state (visit). During the first visit, the capsule was ingested after an overnight fast. During a second visit, the capsule was ingested after a nutritional drink to simulate fed state. Linear mixed models were constructed to compare segmental gastrointestinal transit, pressure and pH between groups (obesity or control) and within every group (fasted or fed).
RESULTS
RESULTS
Food intake slowed gastric emptying in both groups (both P < 0.0001), though food-induced gastric contractility was higher in participants with obesity compared to controls (P = 0.02). In the small intestine, a higher contractility (P = 0.001), shorter transit (P = 0.04) and lower median pH (P = 0.002) was observed in participants with obesity compared to controls. No differences were observed for colonic measurements.
CONCLUSION
CONCLUSIONS
Obesity has a profound impact on gastrointestinal physiology, which should be taken into account for drug development.
Identifiants
pubmed: 34273543
pii: S0939-6411(21)00183-1
doi: 10.1016/j.ejpb.2021.07.002
pii:
doi:
Substances chimiques
Capsules
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
1-8Informations de copyright
Copyright © 2021 Elsevier B.V. All rights reserved.