Gastrointestinal Fluid Volumes in Pediatrics: A Retrospective MRI Study.
MRI
PBPK
biorelevant dissolution
gastric fluid
intestinal fluid
pediatrics
Journal
Pharmaceutics
ISSN: 1999-4923
Titre abrégé: Pharmaceutics
Pays: Switzerland
ID NLM: 101534003
Informations de publication
Date de publication:
13 Sep 2022
13 Sep 2022
Historique:
received:
18
08
2022
revised:
02
09
2022
accepted:
05
09
2022
entrez:
23
9
2022
pubmed:
24
9
2022
medline:
24
9
2022
Statut:
epublish
Résumé
The volume and distribution of fluids available in the gastrointestinal (GI) tract may substantially affect oral drug absorption. Magnetic resonance imaging (MRI) has been used in the past to quantify these fluid volumes in adults and its use is now being extended to the pediatric population. The present research pursued a retrospective, explorative analysis of existing clinical MRI data generated for pediatric patients. Images of 140 children from all pediatric subpopulations were analyzed for their resting GI fluid volumes in fasting conditions. In general, an increase in fluid volume as a function of age was observed for the stomach, duodenum, jejunum, and small intestine (SI) as a whole. No specific pattern was observed for the ileum and colon. Body mass index (BMI), body weight, body height, and SI length were evaluated as easy-to-measure clinical estimators of the gastric and SI fluid volumes. Although weight and height were identified as the best estimators, none performed ideally based on the coefficient of determination (R
Identifiants
pubmed: 36145683
pii: pharmaceutics14091935
doi: 10.3390/pharmaceutics14091935
pmc: PMC9502126
pii:
doi:
Types de publication
Journal Article
Langues
eng
Subventions
Organisme : Research Foundation - Flanders
ID : G0A8119N
Organisme : Roche (Switzerland)
ID : na
Commentaires et corrections
Type : ErratumIn
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