Approaches to Account for Colon Absorption in Physiologically Based Biopharmaceutics Modeling of Extended-Release Drug Products.

Humans Biopharmaceutics / methods Intestinal Absorption / physiology Pharmaceutical Preparations / metabolism Biological Availability Colon / metabolism Models, Biological Solubility Administration, Oral
PBBM PBPK colon absorption extended release physiologically based biopharmaceutics modeling regulatory applications

Journal

Molecular pharmaceutics
ISSN: 1543-8392
Titre abrégé: Mol Pharm
Pays: United States
ID NLM: 101197791

Informations de publication

Date de publication:
04 Dec 2023
Historique:
medline: 5 12 2023
pubmed: 30 10 2023
entrez: 30 10 2023
Statut: ppublish

Résumé

The rate and extent of colon absorption are important determinants of the

Identifiants

DOI: 10.1021/acs.molpharmaceut.3c00683 PMID: 37902586
pubmed: 37902586
doi: 10.1021/acs.molpharmaceut.3c00683
doi:

Substances chimiques

Pharmaceutical Preparations 0

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

6272-6288

Auteurs

Harshad Jadhav (H)

Oral Product Development, Pharmaceutical Technology & Development, Operations, AstraZeneca Gothenburg, S-431 83 Mölndal, Sweden.
Department of Pharmaceutical and Pharmacological Sciences, KU Leuven, ON2 Herestraat 49, 3000 Leuven, Belgium.
ORCID: 0000-0002-8664-4688

Patrick Augustijns (P)

Department of Pharmaceutical and Pharmacological Sciences, KU Leuven, ON2 Herestraat 49, 3000 Leuven, Belgium.
ORCID: 0000-0003-2595-388X

Christer Tannergren (C)

Oral Product Development, Pharmaceutical Technology & Development, Operations, AstraZeneca Gothenburg, S-431 83 Mölndal, Sweden.
ORCID: 0000-0003-3897-337X

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Approaches to Account for Colon Absorption in...
questionsmedicales.fr › Professions de santé › Pharmacologie › Biopharmacie › Approaches to Account for Colon Absorption in...
questionsmedicales.fr › Phénomènes physiologiques de l'appareil buccodentaire et de l'appareil digestif › Phénomènes physiologiques de l'appareil digestif › Absorption gastro-intestinale › Absorption intestinale › Approaches to Account for Colon Absorption in...
questionsmedicales.fr › Préparations pharmaceutiques › Approaches to Account for Colon Absorption in...
questionsmedicales.fr › Phénomènes physiologiques › Phénomènes pharmacologiques et toxicologiques › Pharmacocinétique › Biodisponibilité › Approaches to Account for Colon Absorption in...
questionsmedicales.fr › Système digestif › Tube digestif › Tube digestif inférieur › Gros intestin › Côlon › Approaches to Account for Colon Absorption in...
questionsmedicales.fr › Techniques d'investigation › Modèles théoriques › Modèles biologiques › Approaches to Account for Colon Absorption in...
questionsmedicales.fr › Phénomènes chimiques › Solubilité › Approaches to Account for Colon Absorption in...
questionsmedicales.fr › Thérapeutique › Traitement médicamenteux › Voies d'administration de substances chimiques et des médicaments › Administration par voie orale › Approaches to Account for Colon Absorption in...