Effect of sleeve gastrectomy and Roux-en-Y gastric bypass on gastrointestinal physiology.
Bariatric surgery
Bile acids
Gastric emptying
Gastrointestinal pH
Gastrointestinal physiology
Gastrointestinal pressure
Gastrointestinal transit time
Roux-en-Y gastric bypass
Sleeve gastrectomy
Wireless motility capsule
Journal
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V
ISSN: 1873-3441
Titre abrégé: Eur J Pharm Biopharm
Pays: Netherlands
ID NLM: 9109778
Informations de publication
Date de publication:
Feb 2023
Feb 2023
Historique:
received:
18
08
2022
revised:
07
12
2022
accepted:
30
12
2022
pubmed:
6
1
2023
medline:
1
2
2023
entrez:
5
1
2023
Statut:
ppublish
Résumé
Knowledge regarding the gastrointestinal physiology after sleeve gastrectomy and Roux-en-Y gastric bypass is urgently needed to understand, prevent and treat the nutritional and pharmacological complications of bariatric surgery. To investigate the effect of sleeve gastrectomy and Roux-en-Y gastric bypass on gastrointestinal motility (e.g., transit and pressure), pH, and intestinal bile acid concentration. An exploratory cross-sectional study was performed in six participants living with obesity, six participants who underwent sleeve gastrectomy, and six participants who underwent Roux-en-Y gastric bypass. During the first visit, a wireless motility capsule (SmartPill©) was ingested after an overnight fast to measure gastrointestinal transit, pH, and pressure. During the second visit, a gastric emptying scintigraphy test of a nutritional drink labeled with Immediate pouch emptying (P = 0.0007) and a trend for faster GET The anatomical alterations of sleeve gastrectomy and Roux-en-Y gastric bypass have an important impact on gastrointestinal physiology. This data confirms changes in transit and pH and provides the first evidence for altered intraluminal bile acid concentration.
Sections du résumé
BACKGROUND
BACKGROUND
Knowledge regarding the gastrointestinal physiology after sleeve gastrectomy and Roux-en-Y gastric bypass is urgently needed to understand, prevent and treat the nutritional and pharmacological complications of bariatric surgery.
AIM
OBJECTIVE
To investigate the effect of sleeve gastrectomy and Roux-en-Y gastric bypass on gastrointestinal motility (e.g., transit and pressure), pH, and intestinal bile acid concentration.
MATERIAL AND METHODS
METHODS
An exploratory cross-sectional study was performed in six participants living with obesity, six participants who underwent sleeve gastrectomy, and six participants who underwent Roux-en-Y gastric bypass. During the first visit, a wireless motility capsule (SmartPill©) was ingested after an overnight fast to measure gastrointestinal transit, pH, and pressure. During the second visit, a gastric emptying scintigraphy test of a nutritional drink labeled with
RESULTS
RESULTS
Immediate pouch emptying (P = 0.0007) and a trend for faster GET
CONCLUSION
CONCLUSIONS
The anatomical alterations of sleeve gastrectomy and Roux-en-Y gastric bypass have an important impact on gastrointestinal physiology. This data confirms changes in transit and pH and provides the first evidence for altered intraluminal bile acid concentration.
Identifiants
pubmed: 36603693
pii: S0939-6411(22)00323-X
doi: 10.1016/j.ejpb.2022.12.018
pii:
doi:
Substances chimiques
Bile Acids and Salts
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
92-101Informations de copyright
Copyright © 2022 Elsevier B.V. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.