Tetrahydrobenzimidazole TMQ0153 triggers apoptosis, autophagy and necroptosis crosstalk in chronic myeloid leukemia.
Animals
Antineoplastic Agents
/ pharmacology
Apoptosis
/ drug effects
Autophagy
/ drug effects
Benzimidazoles
/ pharmacology
Calcium
/ metabolism
Dose-Response Relationship, Drug
Energy Metabolism
/ drug effects
Gene Expression Regulation, Leukemic
Humans
K562 Cells
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
/ drug therapy
Membrane Potential, Mitochondrial
/ drug effects
Necroptosis
/ drug effects
Oxidative Stress
/ drug effects
Reactive Oxygen Species
/ metabolism
Signal Transduction
Zebrafish
Journal
Cell death & disease
ISSN: 2041-4889
Titre abrégé: Cell Death Dis
Pays: England
ID NLM: 101524092
Informations de publication
Date de publication:
07 02 2020
07 02 2020
Historique:
received:
11
10
2019
accepted:
16
01
2020
revised:
15
01
2020
entrez:
9
2
2020
pubmed:
9
2
2020
medline:
10
3
2021
Statut:
epublish
Résumé
By comparing imatinib-sensitive and -resistant chronic myeloid leukemia (CML) cell models, we investigated the molecular mechanisms by which tetrahydrobenzimidazole derivative TMQ0153 triggered caspase-dependent apoptosis at low concentrations accompanied by loss of mitochondrial membrane potential (MMP) and increase of cytosolic free Ca
Identifiants
pubmed: 32034134
doi: 10.1038/s41419-020-2304-8
pii: 10.1038/s41419-020-2304-8
pmc: PMC7007439
doi:
Substances chimiques
Antineoplastic Agents
0
Benzimidazoles
0
Reactive Oxygen Species
0
Calcium
SY7Q814VUP
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
109Références
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