Prevalence of denervation in the intrinsic foot muscles in patients with distal predominantly small fiber neuropathy.
Action Potentials
Adolescent
Adult
Aged
Aged, 80 and over
Electrodiagnosis
Electromyography
Epidermis
/ pathology
Female
Foot
/ innervation
Humans
Male
Middle Aged
Muscle, Skeletal
/ innervation
Nerve Fibers
/ pathology
Neural Conduction
/ physiology
Retrospective Studies
Small Fiber Neuropathy
/ pathology
Sural Nerve
/ physiopathology
Thigh
Young Adult
denervation
electromyography
intra-epidermal nerve fiber density
large fiber neuropathy
skin biopsy
small fiber neuropathy
Journal
Muscle & nerve
ISSN: 1097-4598
Titre abrégé: Muscle Nerve
Pays: United States
ID NLM: 7803146
Informations de publication
Date de publication:
05 2020
05 2020
Historique:
received:
04
08
2019
revised:
01
02
2020
accepted:
03
02
2020
pubmed:
9
2
2020
medline:
7
7
2020
entrez:
9
2
2020
Statut:
ppublish
Résumé
We aimed to evaluate the significance of electromyographic findings in the intrinsic foot muscles (IFMs) of patients with skin biopsy proven small fiber neuropathy (SFN). This was a single-center retrospective analysis of patients who underwent skin biopsy for intra-epidermal nerve fiber density (IENFD) measurement and electrodiagnostic (EDX) study for evaluation of polyneuropathy. A total of 1416 patents with normal lower extremity EDX studies proximal to the foot were included. Active denervation was seen in 16.1% of IFMs in patients with skin biopsy proven SFN and 4.1% of patients without SFN (P < .0001). Reinnervation changes without active denervation were observed in 30.4% of SFN patients and 23.8% of patients without SFN (P = .01). IENFD was lower in SFN patients with active denervation in IFMs than without (P < .0001). Evaluation of active denervation in the IFMs can reveal large fiber dysfunction in SFN patients with otherwise normal routine EDX findings.
Sections du résumé
BACKGROUND
We aimed to evaluate the significance of electromyographic findings in the intrinsic foot muscles (IFMs) of patients with skin biopsy proven small fiber neuropathy (SFN).
METHODS
This was a single-center retrospective analysis of patients who underwent skin biopsy for intra-epidermal nerve fiber density (IENFD) measurement and electrodiagnostic (EDX) study for evaluation of polyneuropathy.
RESULTS
A total of 1416 patents with normal lower extremity EDX studies proximal to the foot were included. Active denervation was seen in 16.1% of IFMs in patients with skin biopsy proven SFN and 4.1% of patients without SFN (P < .0001). Reinnervation changes without active denervation were observed in 30.4% of SFN patients and 23.8% of patients without SFN (P = .01). IENFD was lower in SFN patients with active denervation in IFMs than without (P < .0001).
CONCLUSIONS
Evaluation of active denervation in the IFMs can reveal large fiber dysfunction in SFN patients with otherwise normal routine EDX findings.
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
595-599Informations de copyright
© 2020 Wiley Periodicals, Inc.
Références
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