Functions of histone modifications and histone modifiers in Schwann cells.
Schwann cells
development
histone modifications
histone modifiers
injury response
maintenance of PNS integrity
regeneration
Journal
Glia
ISSN: 1098-1136
Titre abrégé: Glia
Pays: United States
ID NLM: 8806785
Informations de publication
Date de publication:
08 2020
08 2020
Historique:
received:
14
10
2019
revised:
24
01
2020
accepted:
28
01
2020
pubmed:
9
2
2020
medline:
19
8
2021
entrez:
9
2
2020
Statut:
ppublish
Résumé
Schwann cells (SCs) are the main glial cells present in the peripheral nervous system (PNS). Their primary functions are to insulate peripheral axons to protect them from the environment and to enable fast conduction of electric signals along big caliber axons by enwrapping them in a thick myelin sheath rich in lipids. In addition, SCs have the peculiar ability to foster axonal regrowth after a lesion by demyelinating and converting into repair cells that secrete neurotrophic factors and guide axons back to their former target to finally remyelinate regenerated axons. The different steps of SC development and their role in the maintenance of PNS integrity and regeneration after lesion are controlled by various factors among which transcription factors and chromatin-remodeling enzymes hold major functions. In this review, we discussed how histone modifications and histone-modifying enzymes control SC development, maintenance of PNS integrity and response to injury. The functions of histone modifiers as part of chromatin-remodeling complexes are discussed in another review published in the same issue of Glia.
Substances chimiques
Histones
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
1584-1595Subventions
Organisme : National Institutes of Health (NIH)
ID : 1R21CA235415-01A1
Pays : International
Informations de copyright
© 2020 The Authors. Glia published by Wiley Periodicals, Inc.
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