Glycocalyx in Endotoxemia and Sepsis.
Journal
The American journal of pathology
ISSN: 1525-2191
Titre abrégé: Am J Pathol
Pays: United States
ID NLM: 0370502
Informations de publication
Date de publication:
04 2020
04 2020
Historique:
received:
18
04
2019
revised:
30
05
2019
accepted:
06
06
2019
pubmed:
10
2
2020
medline:
10
5
2020
entrez:
10
2
2020
Statut:
ppublish
Résumé
Along with the recognition of a crucial role played by endothelial dysfunction secondarily igniting cardiovascular, pulmonary, and renal complications, investigational focus has extended toward endothelial glycocalyx. This delicate coating of cells, including the vascular endothelium, regulates permeability, leukocyte traffic, nitric oxide production, and coagulation, and harbors diverse growth and survival factors. In this brief overview, we discuss the metabolic signatures of sepsis as they relate to the loss of glycocalyx integrity and highlight the contribution of several proteases, heparanase, and hyaluronidase to the shedding of glycocalyx. Clinical manifestations of glycocalyx degradation in unraveling acute respiratory distress syndrome and the cardiovascular, microcirculatory, and renal complications of sepsis are concisely presented. Finally, we list therapeutic strategies for preventing the degradation of, and for restoration of, the glycocalyx.
Identifiants
pubmed: 32035882
pii: S0002-9440(20)30071-7
doi: 10.1016/j.ajpath.2019.06.017
pmc: PMC7180514
pii:
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
791-798Subventions
Organisme : NHLBI NIH HHS
ID : R01 HL144528
Pays : United States
Informations de copyright
Copyright © 2020 American Society for Investigative Pathology. Published by Elsevier Inc. All rights reserved.
Références
Matrix Biol. 2018 Oct;71-72:421-431
pubmed: 29408548
Clin Sci (Lond). 2014 Jan 1;126(1):31-9
pubmed: 24020445
J Intern Med. 2016 Jul;280(1):97-113
pubmed: 26749537
Am J Physiol Heart Circ Physiol. 2004 May;286(5):H1672-80
pubmed: 14704229
Chest. 2019 Feb;155(2):427-437
pubmed: 30171861
Nat Rev Mol Cell Biol. 2013 May;14(5):283-96
pubmed: 23609508
Pharmacol Rep. 2006;58 Suppl:75-80
pubmed: 17332675
J Am Soc Nephrol. 2008 Dec;19(12):2321-30
pubmed: 18715993
Front Cell Infect Microbiol. 2017 Apr 25;7:138
pubmed: 28487846
J Crit Care. 2018 Feb;43:122-127
pubmed: 28881261
Sci Rep. 2018 Mar 26;8(1):5220
pubmed: 29581529
Nephrol Dial Transplant. 2008 Mar;23(3):904-9
pubmed: 18065435
Nat Med. 2012 Aug;18(8):1217-23
pubmed: 22820644
J Thromb Haemost. 2015 Oct;13(10):1743-56
pubmed: 26190521
EMBO Mol Med. 2018 Aug;10(8):
pubmed: 29976786
Acta Anaesthesiol Scand. 2014 Jan;58(1):36-43
pubmed: 24341693
Pharmaceuticals (Basel). 2017 Mar 29;10(2):
pubmed: 28353658
Cell. 2010 Mar 19;140(6):805-20
pubmed: 20303872
Nature. 2014 Oct 9;514(7521):187-92
pubmed: 25119034
Matrix Biol. 2013 Jun 24;32(5):234-240
pubmed: 23499528
Kidney Int. 2014 Jan;85(1):72-81
pubmed: 23903370
J Vasc Res. 2011;48(4):297-306
pubmed: 21273784
JAMA. 2013 Mar 20;309(11):1154-62
pubmed: 23512062
Tissue Eng Part C Methods. 2008 Jun;14(2):141-7
pubmed: 18544029
Clin Microbiol Rev. 2009 Apr;22(2):224-39, Table of Contents
pubmed: 19366913
Eur J Cell Biol. 2006 Aug;85(8):699-715
pubmed: 16822580
Intensive Care Med. 2013 Oct;39(10):1839-42
pubmed: 23925547
Microvasc Res. 2009 Mar;77(2):174-86
pubmed: 19121327
Blood. 2003 May 15;101(10):3765-77
pubmed: 12543869
Am J Physiol. 1999 Aug;277(2):H508-14
pubmed: 10444475
Crit Care Med. 2010 Aug;38(8):1685-94
pubmed: 20562702
Drug Resist Updat. 2016 Nov;29:54-75
pubmed: 27912844
Int J Biochem Cell Biol. 2006;38(12):2018-39
pubmed: 16901744
Biomaterials. 2013 Jul;34(22):5670-6
pubmed: 23623426
Basic Res Cardiol. 2010 Nov;105(6):687-701
pubmed: 20859744
BMC Biol. 2012 Jul 19;10:62
pubmed: 22809326
Biomaterials. 2011 Jan;32(1):288-94
pubmed: 20932573
Crit Care Med. 2018 Apr;46(4):625-634
pubmed: 29227368
Sci Rep. 2018 May 1;8(1):6811
pubmed: 29717213
Medicine (Baltimore). 2016 Apr;95(16):e3374
pubmed: 27100422
Microvasc Res. 2012 May;83(3):337-46
pubmed: 22349291
Microvasc Res. 2013 Nov;90:80-5
pubmed: 23899417
Am J Physiol Heart Circ Physiol. 2006 Oct;291(4):H1536-44
pubmed: 16489107
Kidney Int. 2012 Jul;82(1):53-9
pubmed: 22437417
Br J Anaesth. 2011 Nov;107(5):679-86
pubmed: 21890663
Biochim Biophys Acta Mol Cell Res. 2017 Nov;1864(11 Pt A):1927-1939
pubmed: 28636874
J Pharmacol Exp Ther. 2017 Apr;361(1):115-121
pubmed: 28167639
Immunol Res. 2005;31(3):207-18
pubmed: 15888912
Nature. 2011 Oct 16;479(7371):117-21
pubmed: 22002608
Intensive Care Med. 2000 Sep;26(9):1364-8
pubmed: 11089766
Chest. 2018 Aug;154(2):317-325
pubmed: 29555594
Nature. 1998 Apr 23;392(6678):799-801
pubmed: 9572137
Nephrol Dial Transplant. 2012 Oct;27(10):3771-81
pubmed: 22529164
Br J Anaesth. 2010 Apr;104(4):414-21
pubmed: 20172938
Am J Pathol. 2016 Feb;186(2):248-58
pubmed: 26683662
Thromb Res. 2018 Nov;171:1-6
pubmed: 30216821
J Immunol. 2002 Jun 1;168(11):5817-23
pubmed: 12023385
Am J Pathol. 1978 Nov;93(2):526-618
pubmed: 362943