The expression of the P2Y
A549 Cells
Amino Acid Substitution
Caco-2 Cells
Cell Proliferation
Chromatin Immunoprecipitation
Gene Expression Regulation, Neoplastic
Genes, Reporter
HCT116 Cells
HT29 Cells
Humans
Luciferases
/ genetics
Neoplasm Proteins
/ genetics
Promoter Regions, Genetic
Protein Binding
Receptors, Purinergic P2
/ genetics
Signal Transduction
Transcription, Genetic
Tumor Suppressor Protein p53
/ genetics
Cancer
Inflammation
Intestine
P2Y(6)
Transcription
p53
Journal
Biochemical and biophysical research communications
ISSN: 1090-2104
Titre abrégé: Biochem Biophys Res Commun
Pays: United States
ID NLM: 0372516
Informations de publication
Date de publication:
16 04 2020
16 04 2020
Historique:
received:
10
01
2020
accepted:
29
01
2020
pubmed:
11
2
2020
medline:
21
10
2020
entrez:
11
2
2020
Statut:
ppublish
Résumé
Inflammatory bowel disease (IBD) is a risk factor for the development of colorectal cancer (CRC) for which mutation to p53 is an early event leading to dysplasia. Interestingly, P2RY6 mRNA increases in both pathologies. In this study, we investigated if p53 and p53
Identifiants
pubmed: 32037085
pii: S0006-291X(20)30246-1
doi: 10.1016/j.bbrc.2020.01.161
pii:
doi:
Substances chimiques
Neoplasm Proteins
0
Receptors, Purinergic P2
0
Tumor Suppressor Protein p53
0
purinoceptor P2Y6
0
Luciferases
EC 1.13.12.-
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
798-802Subventions
Organisme : CIHR
ID : MOP-286567
Pays : Canada
Informations de copyright
Copyright © 2020 Elsevier Inc. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.