Phenotypic and Transcriptomic Lymphocytes Changes in Allograft Recipients After Intravenous Immunoglobulin Therapy in Kidney Transplant Recipients.
Adult
Aged
Allografts
Female
Graft Rejection
/ blood
Graft Survival
/ drug effects
HLA Antigens
/ immunology
Humans
Immunization, Passive
/ methods
Immunoglobulin G
/ blood
Immunoglobulins, Intravenous
/ administration & dosage
Kidney Transplantation
Lymphocytes
/ immunology
Male
Middle Aged
Phenotype
Prospective Studies
Tissue Donors
Transcriptome
Transplant Recipients
Transplantation, Homologous
donor specific antibodies
high-dose intravenous immunoglobulin
immunomodulation
kidney transplantation
lymphocytes phenotype
Journal
Frontiers in immunology
ISSN: 1664-3224
Titre abrégé: Front Immunol
Pays: Switzerland
ID NLM: 101560960
Informations de publication
Date de publication:
2020
2020
Historique:
received:
22
09
2019
accepted:
08
01
2020
entrez:
11
2
2020
pubmed:
11
2
2020
medline:
24
2
2021
Statut:
epublish
Résumé
High dose intravenous immunoglobulin (IVIG) are widely used after kidney transplantation and its biological effect on T and B cell phenotype in the context of maintenance immunosuppression was not documented yet. We designed a monocentric prospective cohort study of kidney allograft recipients with anti-HLA donor specific antibodies (DSA) without acute rejection on screening biopsies treated with prophylactic high-dose IVIG (2 g/kg) monthly for 2 months. Any previous treatment with Rituximab was an exclusion criterion. We performed an extensive analysis of phenotypic and transcriptomic T and B lymphocytes changes and serum cytokines after treatment (day 60). Twelve kidney transplant recipients who completed at least two courses of high-dose IVIG (2 g/kg) were included in a median time of 45 (12-132) months after transplant. Anti-HLA DSA characteristics were similar before and after treatment. At D60, PBMC population distribution was similar to the day before the first infusion. CD8
Identifiants
pubmed: 32038663
doi: 10.3389/fimmu.2020.00034
pmc: PMC6993066
doi:
Substances chimiques
HLA Antigens
0
Immunoglobulin G
0
Immunoglobulins, Intravenous
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
34Informations de copyright
Copyright © 2020 Pilon, Bigot, Grondin, Thiolat, Lang, Cohen, Grimbert and Matignon.
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