Preclinical Antimalarial Combination Study of M5717, a Plasmodium falciparum Elongation Factor 2 Inhibitor, and Pyronaridine, a Hemozoin Formation Inhibitor.

Animals Antimalarials / pharmacokinetics Drug Resistance / physiology Drug Therapy, Combination Hemeproteins / antagonists & inhibitors Malaria, Falciparum / drug therapy Mice Mice, SCID Naphthyridines / pharmacokinetics Peptide Elongation Factor 2 / antagonists & inhibitors Plasmodium falciparum / drug effects Quinolines / chemistry
M5717 Plasmodium falciparum SCID mouse drug combination isobologram malaria pyronaridine resistant mutant

Journal

Antimicrobial agents and chemotherapy
ISSN: 1098-6596
Titre abrégé: Antimicrob Agents Chemother
Pays: United States
ID NLM: 0315061

Informations de publication

Date de publication:
24 03 2020
Historique:
received: 06 11 2019
accepted: 31 01 2020
pubmed: 12 2 2020
medline: 29 1 2021
entrez: 12 2 2020
Statut: epublish

Résumé

Antimalarial drug resistance in the

Identifiants

DOI: 10.1128/AAC.02181-19 PMID: 32041711 PMC: PMC7179297
pubmed: 32041711
pii: AAC.02181-19
doi: 10.1128/AAC.02181-19
pmc: PMC7179297
pii:
doi:

Substances chimiques

Antimalarials 0
DDD107498 0
Hemeproteins 0
Naphthyridines 0
Peptide Elongation Factor 2 0
Quinolines 0
quinoline-4-carboxamide 0
hemozoin 39404-00-7
pyronaridine TD3P7Q3SG6

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Informations de copyright

Copyright © 2020 Rottmann et al.

Références

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Auteurs

Matthias Rottmann (M)

Department of Medical Parasitology and Infection Biology, Swiss Tropical and Public Health Institute, Basel, Switzerland.
University of Basel, Basel, Switzerland.

Brian Jonat (B)

Department of Pediatrics, Columbia University Irving Medical Center, New York, New York, USA.

Christin Gumpp (C)

Department of Medical Parasitology and Infection Biology, Swiss Tropical and Public Health Institute, Basel, Switzerland.
University of Basel, Basel, Switzerland.

Satish K Dhingra (SK)

Department of Microbiology and Immunology, Columbia University Irving Medical Center, New York, New York, USA.

Marla J Giddins (MJ)

Department of Microbiology and Immunology, Columbia University Irving Medical Center, New York, New York, USA.

Xiaoyan Yin (X)

Global Statistics for NDD, Immunology, Endocrinology, Fertility & Others, EMD Serono, Billerica, Massachusetts, USA.

Lassina Badolo (L)

Discovery and Development Technologies, Merck Healthcare KGaA, Darmstadt, Germany.

Beatrice Greco (B)

Global Health Institute of Merck, Eysins, Switzerland.

David A Fidock (DA)

Department of Microbiology and Immunology, Columbia University Irving Medical Center, New York, New York, USA.
Division of Infectious Diseases, Department of Medicine, Columbia University Irving Medical Center, New York, New York, USA.

Claude Oeuvray (C)

Global Health Institute of Merck, Eysins, Switzerland.

Thomas Spangenberg (T)

Global Health Institute of Merck, Eysins, Switzerland thomas.spangenberg@merckgroup.com.
ORCID: 0000-0002-5654-8919

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Preclinical Antimalarial Combination Study of...
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Utilisations thérapeutiques › Anti-infectieux › Antiparasitaires › Antiprotozoaires › Antipaludiques › Preclinical Antimalarial Combination Study of...
questionsmedicales.fr › Phénomènes physiologiques › Phénomènes pharmacologiques et toxicologiques › Phénomènes pharmacologiques › Résistance aux substances › Preclinical Antimalarial Combination Study of...
questionsmedicales.fr › Thérapeutique › Traitement médicamenteux › Association de médicaments › Preclinical Antimalarial Combination Study of...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Hémoprotéines › Preclinical Antimalarial Combination Study of...
questionsmedicales.fr › Infection › Maladies vectorielles › Paludisme › Paludisme à Plasmodium falciparum › Preclinical Antimalarial Combination Study of...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Preclinical Antimalarial Combination Study of...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Souches mutantes de souris › Souris SCID › Preclinical Antimalarial Combination Study of...
questionsmedicales.fr › Composés hétérocycliques › Composés hétérocycliques à cycles fusionnés › Composés hétérobicycliques › Naphtyridines › Preclinical Antimalarial Combination Study of...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines ribosomiques › Facteurs élongation chaîne peptidique › Facteurs d'élongation liés à la GTP phosphohydrolase › Facteur-2 d'élongation de la chaîne peptidique › Preclinical Antimalarial Combination Study of...
questionsmedicales.fr › Eucaryotes › Alveolata › Apicomplexa › Haemosporida › Plasmodium › Plasmodium falciparum › Preclinical Antimalarial Combination Study of...
questionsmedicales.fr › Composés hétérocycliques › Composés hétérocycliques à cycles fusionnés › Composés hétérobicycliques › Quinoléines › Preclinical Antimalarial Combination Study of...