Structural analysis of a trimeric assembly of the mitochondrial dynamin-like GTPase Mgm1.

Crystallography, X-Ray GTP-Binding Proteins / chemistry Guanosine Diphosphate / chemistry Lipid Metabolism Membrane Fusion Mitochondria / enzymology Mitochondrial Proteins / chemistry Models, Molecular Mutation Protein Conformation Saccharomyces cerevisiae / metabolism Saccharomyces cerevisiae Proteins / chemistry
dynamin inner membrane membrane fusion mitochondria structure

Journal

Proceedings of the National Academy of Sciences of the United States of America
ISSN: 1091-6490
Titre abrégé: Proc Natl Acad Sci U S A
Pays: United States
ID NLM: 7505876

Informations de publication

Date de publication:
25 02 2020
Historique:
pubmed: 12 2 2020
medline: 1 7 2020
entrez: 12 2 2020
Statut: ppublish

Résumé

The fusion of inner mitochondrial membranes requires dynamin-like GTPases, Mgm1 in yeast and OPA1 in mammals, but how they mediate membrane fusion is poorly understood. Here, we determined the crystal structure of

Identifiants

DOI: 10.1073/pnas.1919116117 PMID: 32041880 PMC: PMC7049166
pubmed: 32041880
pii: 1919116117
doi: 10.1073/pnas.1919116117
pmc: PMC7049166
doi:

Substances chimiques

MGM1 protein, S cerevisiae 0
Mitochondrial Proteins 0
Saccharomyces cerevisiae Proteins 0
Guanosine Diphosphate 146-91-8
GTP-Binding Proteins EC 3.6.1.-

Banques de données

PDB
['6JSJ']

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

4061-4070

Subventions

Organisme : NIGMS NIH HHS
ID : R37 GM097432
Pays : United States
Organisme : NIGMS NIH HHS
ID : R01 GM126081
Pays : United States

Informations de copyright

Copyright © 2020 the Author(s). Published by PNAS.

Déclaration de conflit d'intérêts

The authors declare no competing interest.

Références

Nat Rev Mol Cell Biol. 2006 Sep;7(9):631-43
pubmed: 16912714
J Cell Biol. 2016 Dec 5;215(5):621-629
pubmed: 27920125
Cell. 2006 Oct 20;127(2):383-95
pubmed: 17055438
Elife. 2018 Feb 22;7:
pubmed: 29469807
Science. 2009 Jan 23;323(5913):474-7
pubmed: 19164740
J Cell Biol. 2016 Feb 15;212(4):379-87
pubmed: 26858267
Biochem Biophys Res Commun. 2003 Aug 22;308(2):276-83
pubmed: 12901865
Curr Genet. 1993 Jul-Aug;24(1-2):141-8
pubmed: 7916673
Nature. 2011 Sep 18;477(7366):556-60
pubmed: 21927000
J Cell Biol. 2007 Aug 27;178(5):749-55
pubmed: 17709429
J Cell Biol. 2007 Aug 27;178(5):757-64
pubmed: 17709430
Nature. 2017 Feb 16;542(7641):372-376
pubmed: 28114303
Proc Natl Acad Sci U S A. 2012 Aug 7;109(32):E2146-54
pubmed: 22802620
J Biol Chem. 2006 Jan 27;281(4):2177-83
pubmed: 16272155
Biochim Biophys Acta Bioenerg. 2018 Apr;1859(4):263-269
pubmed: 29382469
Proc Natl Acad Sci U S A. 2015 Apr 14;112(15):E1851-60
pubmed: 25825753
J Cell Biol. 2000 Oct 16;151(2):341-52
pubmed: 11038181
J Cell Biol. 2005 Sep 26;170(7):1021-7
pubmed: 16186251
J Cell Biol. 2009 Sep 21;186(6):793-803
pubmed: 19752025
Mol Biol Cell. 2003 Jun;14(6):2342-56
pubmed: 12808034
J Cell Biol. 1998 Oct 19;143(2):333-49
pubmed: 9786946
Hum Mol Genet. 2010 Jun 1;19(11):2113-22
pubmed: 20185555
Nature. 2019 Jul;571(7765):429-433
pubmed: 31292547
Science. 2012 Aug 31;337(6098):1062-5
pubmed: 22936770
J Biol Chem. 2003 Jul 25;278(30):27781-8
pubmed: 12707284
Proc Natl Acad Sci U S A. 2011 Mar 8;108(10):3976-81
pubmed: 21368113
Nature. 2009 Aug 20;460(7258):978-83
pubmed: 19633650
J Mol Biol. 2015 Aug 14;427(16):2599-609
pubmed: 25784211
Genes Dev. 1992 Mar;6(3):380-9
pubmed: 1532158
Nat Genet. 2000 Oct;26(2):211-5
pubmed: 11017080
J Biol Chem. 2009 Oct 16;284(42):28682-6
pubmed: 19703904
Nat Struct Mol Biol. 2008 Jul;15(7):658-64
pubmed: 18618939
Annu Rev Physiol. 2016;78:505-31
pubmed: 26667075
Proc Natl Acad Sci U S A. 2004 Nov 9;101(45):15927-32
pubmed: 15509649
J Cell Biol. 1999 Feb 22;144(4):711-20
pubmed: 10037792
Proc Natl Acad Sci U S A. 2017 Nov 14;114(46):E9863-E9872
pubmed: 29093165
Nat Genet. 2000 Oct;26(2):207-10
pubmed: 11017079
Biochemistry. 2009 Mar 3;48(8):1774-84
pubmed: 19236101
J Cell Biol. 1998 Oct 19;143(2):359-73
pubmed: 9786948
Acta Crystallogr D Biol Crystallogr. 2012 Apr;68(Pt 4):352-67
pubmed: 22505256
Acta Crystallogr D Biol Crystallogr. 2004 Dec;60(Pt 12 Pt 1):2126-32
pubmed: 15572765
Semin Cell Dev Biol. 2016 Dec;60:105-111
pubmed: 27269373
Acta Crystallogr D Biol Crystallogr. 2010 Feb;66(Pt 2):125-32
pubmed: 20124692
J Cell Biol. 2003 Feb 3;160(3):303-11
pubmed: 12566426
Cell. 1997 Jul 11;90(1):121-9
pubmed: 9230308
Annu Rev Biochem. 2007;76:751-80
pubmed: 17362197
J Mol Biol. 2002 Nov 8;323(5):835-43
pubmed: 12417197
EMBO J. 2006 Jul 12;25(13):2966-77
pubmed: 16778770
Biochim Biophys Acta. 2009 Jan;1793(1):20-6
pubmed: 18691613
J Cell Biol. 2004 Apr 26;165(2):167-73
pubmed: 15096522
Biochim Biophys Acta. 2009 Dec;1792(12):1138-44
pubmed: 19100831
J Biol Chem. 2006 Dec 8;281(49):37972-9
pubmed: 17003040
Nature. 2003 May 29;423(6939):537-41
pubmed: 12774122
Nat Struct Mol Biol. 2018 Mar;25(3):233-243
pubmed: 29483649
EMBO J. 2007 Jan 24;26(2):559-66
pubmed: 17170701
Yeast. 2000 Nov;16(15):1421-7
pubmed: 11054823
Cell. 2009 Aug 7;138(3):549-61
pubmed: 19665976

Auteurs

Liming Yan (L)

National Laboratory of Macromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China.
School of Medicine, Tsinghua University, Beijing 100084, China.

Yuanbo Qi (Y)

National Laboratory of Macromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China.
College of Life Sciences, Nankai University, and State Key Laboratory of Medicinal Chemical Biology, Tianjin 300071, China.

Derek Ricketson (D)

Department of Molecular and Cellular Biology, University of California, Davis, CA 95616.

Lei Li (L)

School of Medicine, Tsinghua University, Beijing 100084, China.

Kelly Subramanian (K)

Department of Molecular and Cellular Biology, University of California, Davis, CA 95616.

Jinghua Zhao (J)

College of Life Sciences, Nankai University, and State Key Laboratory of Medicinal Chemical Biology, Tianjin 300071, China.

Caiting Yu (C)

School of Medicine, Tsinghua University, Beijing 100084, China.

Lijie Wu (L)

iHuman Institute, ShanghaiTech University, Shanghai 201210, China.

Reta Sarsam (R)

Department of Molecular and Cellular Biology, University of California, Davis, CA 95616.

Melissa Wong (M)

Department of Molecular and Cellular Biology, University of California, Davis, CA 95616.

Zhiyong Lou (Z)

School of Medicine, Tsinghua University, Beijing 100084, China.
ORCID: 0000-0003-2728-881X

Zihe Rao (Z)

National Laboratory of Macromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China; raozh@mail.tsinghua.edu.cn jmnunnari@ucdavis.edu huj@ibp.ac.cn.
School of Medicine, Tsinghua University, Beijing 100084, China.
College of Life Sciences, Nankai University, and State Key Laboratory of Medicinal Chemical Biology, Tianjin 300071, China.

Jodi Nunnari (J)

Department of Molecular and Cellular Biology, University of California, Davis, CA 95616; raozh@mail.tsinghua.edu.cn jmnunnari@ucdavis.edu huj@ibp.ac.cn.

Junjie Hu (J)

National Laboratory of Macromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China; raozh@mail.tsinghua.edu.cn jmnunnari@ucdavis.edu huj@ibp.ac.cn.
College of Life Sciences, University of Chinese Academy of Sciences, Beijing 100049, China.
ORCID: 0000-0003-4712-2243

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Classifications MeSH

questionsmedicales.fr › Techniques d'investigation › Techniques de chimie analytique › Cristallographie aux rayons X › Structural analysis of a trimeric assembly of...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines et peptides de signalisation intracellulaire › Protéines G › Structural analysis of a trimeric assembly of...
questionsmedicales.fr › Acides nucléiques, nucléotides et nucléosides › Nucléotides › Ribonucléotides › Nucléotides guanyliques › Guanosine diphosphate › Structural analysis of a trimeric assembly of...
questionsmedicales.fr › Métabolisme › Métabolisme lipidique › Structural analysis of a trimeric assembly of...
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Fusion membranaire › Structural analysis of a trimeric assembly of...
questionsmedicales.fr › Cellules › Structures cellulaires › Fractions subcellulaires › Mitochondries › Structural analysis of a trimeric assembly of...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines mitochondriales › Structural analysis of a trimeric assembly of...
questionsmedicales.fr › Techniques d'investigation › Modèles théoriques › Modèles moléculaires › Structural analysis of a trimeric assembly of...
questionsmedicales.fr › Phénomènes génétiques › Variation génétique › Mutation › Structural analysis of a trimeric assembly of...
questionsmedicales.fr › Phénomènes chimiques › Phénomènes biochimiques › Conformation moléculaire › Conformation des protéines › Structural analysis of a trimeric assembly of...
questionsmedicales.fr › Eucaryotes › Champignons › Levures › Saccharomyces › Saccharomyces cerevisiae › Structural analysis of a trimeric assembly of...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines fongiques › Protéines de Saccharomyces cerevisiae › Structural analysis of a trimeric assembly of...