The diversity of ACBD proteins - From lipid binding to protein modulators and organelle tethers.
Acyl-CoA binding domain containing protein
FFAT motif
Lipid metabolism
Membrane contact sites
Pathogen host interaction
Peroxisomes
Journal
Biochimica et biophysica acta. Molecular cell research
ISSN: 1879-2596
Titre abrégé: Biochim Biophys Acta Mol Cell Res
Pays: Netherlands
ID NLM: 101731731
Informations de publication
Date de publication:
05 2020
05 2020
Historique:
received:
15
11
2019
revised:
30
01
2020
accepted:
05
02
2020
pubmed:
12
2
2020
medline:
8
8
2020
entrez:
12
2
2020
Statut:
ppublish
Résumé
Members of the large multigene family of acyl-CoA binding domain containing proteins (ACBDs) share a conserved motif required for binding of Coenzyme A esterified fatty acids of various chain length. These proteins are present in the three kingdoms of life, and despite their predicted roles in cellular lipid metabolism, knowledge about the precise functions of many ACBD proteins remains scarce. Interestingly, several ACBD proteins are now suggested to function at organelle contact sites, and are recognized as host interaction proteins for different pathogens including viruses and bacteria. Here, we present a thorough phylogenetic analysis of the ACBD family and discuss their structure and evolution. We summarize recent findings on the various functions of animal and fungal ACBDs with particular focus on peroxisomes, the role of ACBD proteins at organelle membranes, and their increasing recognition as targets for pathogens.
Identifiants
pubmed: 32044385
pii: S0167-4889(20)30033-1
doi: 10.1016/j.bbamcr.2020.118675
pmc: PMC7057175
pii:
doi:
Substances chimiques
Carrier Proteins
0
Fungal Proteins
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
118675Subventions
Organisme : Medical Research Council
ID : MR/N0137941/1
Pays : United Kingdom
Organisme : Biotechnology and Biological Sciences Research Council
ID : BB/M011801/1
Pays : United Kingdom
Organisme : Biotechnology and Biological Sciences Research Council
ID : BB/N01541X/1
Pays : United Kingdom
Organisme : Biotechnology and Biological Sciences Research Council
ID : BB/P003818/1
Pays : United Kingdom
Organisme : Biotechnology and Biological Sciences Research Council
ID : BB/T002255/1
Pays : United Kingdom
Organisme : Medical Research Council
ID : CIC 08135
Pays : United Kingdom
Informations de copyright
Copyright © 2020 The Authors. Published by Elsevier B.V. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
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