Beta-sitosterol attenuates insulin resistance in adipose tissue via IRS-1/Akt mediated insulin signaling in high fat diet and sucrose induced type-2 diabetic rats.
Adipose Tissue
/ drug effects
Animals
Computer Simulation
Diabetes Mellitus, Type 2
/ chemically induced
Diet, High-Fat
Insulin
/ metabolism
Insulin Receptor Substrate Proteins
/ drug effects
Insulin Resistance
Male
Models, Molecular
Molecular Dynamics Simulation
Proto-Oncogene Proteins c-akt
/ drug effects
Rats
Rats, Wistar
Signal Transduction
/ drug effects
Sitosterols
/ pharmacology
Sucrose
/ pharmacology
beta-Arrestin 2
/ drug effects
src-Family Kinases
/ antagonists & inhibitors
High fat diet
IRS-1/Akt signaling
Insulin resistance
Molecular dynamics
Type-2 diabetes
β- Sitosterol
Journal
European journal of pharmacology
ISSN: 1879-0712
Titre abrégé: Eur J Pharmacol
Pays: Netherlands
ID NLM: 1254354
Informations de publication
Date de publication:
15 Apr 2020
15 Apr 2020
Historique:
received:
21
07
2019
revised:
05
02
2020
accepted:
07
02
2020
pubmed:
12
2
2020
medline:
28
11
2020
entrez:
12
2
2020
Statut:
ppublish
Résumé
In our previous study, we have shown that β-sitosterol (SIT) enhances glycemic control by increasing the activation of insulin receptor (IR) and glucose transporter 4 (GLUT4) proteins in adipose tissue. However, the possible role of SIT on the regulation of post-receptor insulin signal transduction is not known. Hence, the study was aimed to assess the effects of SIT on IRS-1/Akt mediated insulin signaling molecules in high-fat diet and sucrose induced type-2 diabetic rats. An oral effective dose of SIT (20 mg/kg b.wt) was given for 30 days to high fat-fed type-2 diabetic rats to find out whether SIT regulates IRS-1/Akt pathway of insulin signaling. The results showed that SIT attenuated the insulin receptor substrate-1 serine phosphorylation (p-IRS-1
Identifiants
pubmed: 32045603
pii: S0014-2999(20)30096-0
doi: 10.1016/j.ejphar.2020.173004
pii:
doi:
Substances chimiques
Insulin
0
Insulin Receptor Substrate Proteins
0
Irs1 protein, rat
0
Sitosterols
0
beta-Arrestin 2
0
Sucrose
57-50-1
gamma-sitosterol
5LI01C78DD
src-Family Kinases
EC 2.7.10.2
Proto-Oncogene Proteins c-akt
EC 2.7.11.1
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
173004Informations de copyright
Copyright © 2020 Elsevier B.V. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of competing interest The authors declare no conflict of interests.