Striatal dynamics as determinants of reduced gambling vulnerability in the NHE rat model of ADHD.

Animals Attention Deficit Disorder with Hyperactivity / genetics Corpus Striatum / metabolism Disease Models, Animal Gambling / genetics Male Rats Rats, Sprague-Dawley Rats, Transgenic
BOLD phMRI Dopamine Dorsal striatum Impulsivity Risky decision making Ventral striatum

Journal

Progress in neuro-psychopharmacology & biological psychiatry
ISSN: 1878-4216
Titre abrégé: Prog Neuropsychopharmacol Biol Psychiatry
Pays: England
ID NLM: 8211617

Informations de publication

Date de publication:
08 06 2020
Historique:
received: 10 10 2019
revised: 03 02 2020
accepted: 07 02 2020
pubmed: 12 2 2020
medline: 29 4 2021
entrez: 12 2 2020
Statut: ppublish

Résumé

The Naples High-Excitability (NHE) is a validated rat strain to model for a mesocortical variant of Attention Deficit Hyperactivity Disorder (ADHD). NHE rats' brains have a tuned-down cortical and a potentiated limbic loop (Zoratto et al., 2017). ADHD and comorbid pathological gambling (PG) involve similar deficits of prefrontal-striatal dialogue. This work aimed to understand if NHE rats (compared to normal random-bred rats, NRB) can be a useful model for gambling vulnerability in ADHD. Experiment 1 evaluated gambling proneness in NHE rats, namely attraction/avoidance in nose-poking for a "Large & Luck-Linked" (LLL) reward (versus a "Small & Sure" one, SS), when the probability of LLL delivery was progressively reduced. Experiment 2 assessed (by phMRI) differential responsivity of ventral (vStr) versus dorsal (dStr) striatum following a methylphenidate (MPH, 4 mg/kg I.P.) challenge. In NHE rats, reduced attraction by secondary cues (associated with uncertain, rarefying LLL delivery) comes along with little or no activation of dStr and enhanced activation of vStr by MPH. Together, such evidences from NHE rats indicate distinctive roles of ventral (enhanced value given to actual primary reward) and dorsal (lower encoding of repeated stimulus-reward associations into a habit) striatum. In conclusion, the dynamics of reward systems could link an attention deficit with a decreased vulnerability to pathological gambling.

Identifiants

DOI: 10.1016/j.pnpbp.2020.109886 PMID: 32045636
pubmed: 32045636
pii: S0278-5846(19)30849-8
doi: 10.1016/j.pnpbp.2020.109886
pii:
doi:

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

109886

Informations de copyright

Copyright © 2020 Elsevier Inc. All rights reserved.

Déclaration de conflit d'intérêts

Declaration of Competing Interest None.

Auteurs

Maurizio Oggiano (M)

Center for Behavioral Science and Mental Health, Istituto Superiore di Sanità, Rome, Italy; Faculty of Psychology, International Telematic University "Uninettuno", Rome, Italy.

Francesca Zoratto (F)

Center for Behavioral Science and Mental Health, Istituto Superiore di Sanità, Rome, Italy.

Gianmauro Palombelli (G)

Core Facilities, Istituto Superiore di Sanità, Rome, Italy.

Fabiana Festucci (F)

Center for Behavioral Science and Mental Health, Istituto Superiore di Sanità, Rome, Italy; Department of Applied Clinical and Biotechnological Sciences, University of L'Aquila, L'Aquila, Italy.

Giovanni Laviola (G)

Center for Behavioral Science and Mental Health, Istituto Superiore di Sanità, Rome, Italy.

Giuseppe Curcio (G)

Department of Applied Clinical and Biotechnological Sciences, University of L'Aquila, L'Aquila, Italy.

Rossella Canese (R)

Core Facilities, Istituto Superiore di Sanità, Rome, Italy.

Walter Adriani (W)

Center for Behavioral Science and Mental Health, Istituto Superiore di Sanità, Rome, Italy; Faculty of Psychology, International Telematic University "Uninettuno", Rome, Italy. Electronic address: walter.adriani@iss.it.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Striatal dynamics as determinants of reduced...
questionsmedicales.fr › Troubles mentaux › Troubles du développement neurologique › Troubles déficitaires de l'attention et du comportement perturbateur › Trouble déficitaire de l'attention avec hyperactivité › Striatal dynamics as determinants of reduced...
questionsmedicales.fr › Système nerveux › Système nerveux central › Encéphale › Prosencéphale › Télencéphale › Cerveau › Noyaux gris centraux › Corps strié › Striatal dynamics as determinants of reduced...
questionsmedicales.fr › Techniques d'investigation › Modèles théoriques › Modèles biologiques › Modèles animaux de maladie humaine › Striatal dynamics as determinants of reduced...
questionsmedicales.fr › Troubles mentaux › Troubles du contrôle des impulsions › Jeu de hasard › Striatal dynamics as determinants of reduced...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Rats › Striatal dynamics as determinants of reduced...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Rats › Rat Sprague-Dawley › Striatal dynamics as determinants of reduced...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Rats › Rats transgéniques › Striatal dynamics as determinants of reduced...