Breast cancer metastasis to bone: From epithelial to mesenchymal transition to breast osteoblast-like cells.
BOLCs
Bone metastasis
Breast cancer
Epithelial to mesenchymal transition
Microcalcifications
Molecular imaging
Journal
Seminars in cancer biology
ISSN: 1096-3650
Titre abrégé: Semin Cancer Biol
Pays: England
ID NLM: 9010218
Informations de publication
Date de publication:
07 2021
07 2021
Historique:
received:
15
11
2019
revised:
13
01
2020
accepted:
13
01
2020
pubmed:
12
2
2020
medline:
4
3
2022
entrez:
12
2
2020
Statut:
ppublish
Résumé
In this review we highlighted the newest aspects concerning the physiopathology of breast cancer metastatization into the bone including: a) in situ biomarkers of breast cancer metastatic diseases, b) biological processes related to the origin of metastatic cells (epithelial to mesenchymal transition), c) the nature and the possible role of Breast Osteoblast-Like Cells in the formation of bone lesions and d) the prognostic value of breast microcalcifications for the bone metastatic disease. In addition, the more recent data about the biology of breast cancer metastatic process and the origin and function of Breast Osteoblast-Like Cells have been analyzed to propose the use of molecular imaging investigations able to identify early neoplastic lesions with high propensity to form bone metastasis in vivo.
Identifiants
pubmed: 32045651
pii: S1044-579X(20)30005-5
doi: 10.1016/j.semcancer.2020.01.004
pii:
doi:
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
155-164Informations de copyright
Copyright © 2020 Elsevier Ltd. All rights reserved.