Trait differentiation and modular toxin expression in palm-pitvipers.
Bothriechis
Gene family evolution
Modularity
Transcriptomics
Venom
Journal
BMC genomics
ISSN: 1471-2164
Titre abrégé: BMC Genomics
Pays: England
ID NLM: 100965258
Informations de publication
Date de publication:
11 Feb 2020
11 Feb 2020
Historique:
received:
26
08
2019
accepted:
30
01
2020
entrez:
13
2
2020
pubmed:
13
2
2020
medline:
30
10
2020
Statut:
epublish
Résumé
Modularity is the tendency for systems to organize into semi-independent units and can be a key to the evolution and diversification of complex biological systems. Snake venoms are highly variable modular systems that exhibit extreme diversification even across very short time scales. One well-studied venom phenotype dichotomy is a trade-off between neurotoxicity versus hemotoxicity that occurs through the high expression of a heterodimeric neurotoxic phospholipase A We assembled 1517 coding sequences, including 43 toxins for B. nigroviridis and 1787 coding sequences including 42 toxins for B. nubestris. The venom gland transcriptomes were extremely divergent between these two species with one B. nigroviridis exhibiting a primarily neurotoxic pattern of expression, both B. nubestris expressing primarily hemorrhagic toxins, and a second B. nigroviridis exhibiting a mixed expression phenotype. Weighted gene coexpression analyses identified six submodules of transcript expression variation, one of which was highly associated with SVMPs and a second which contained both subunits of the neurotoxic PLA Sub-modular regulation of expression likely contributes to the diversification of venom phenotypes within and among species and underscores the role of modularity in facilitating rapid evolution of complex traits.
Sections du résumé
BACKGROUND
BACKGROUND
Modularity is the tendency for systems to organize into semi-independent units and can be a key to the evolution and diversification of complex biological systems. Snake venoms are highly variable modular systems that exhibit extreme diversification even across very short time scales. One well-studied venom phenotype dichotomy is a trade-off between neurotoxicity versus hemotoxicity that occurs through the high expression of a heterodimeric neurotoxic phospholipase A
RESULTS
RESULTS
We assembled 1517 coding sequences, including 43 toxins for B. nigroviridis and 1787 coding sequences including 42 toxins for B. nubestris. The venom gland transcriptomes were extremely divergent between these two species with one B. nigroviridis exhibiting a primarily neurotoxic pattern of expression, both B. nubestris expressing primarily hemorrhagic toxins, and a second B. nigroviridis exhibiting a mixed expression phenotype. Weighted gene coexpression analyses identified six submodules of transcript expression variation, one of which was highly associated with SVMPs and a second which contained both subunits of the neurotoxic PLA
CONCLUSION
CONCLUSIONS
Sub-modular regulation of expression likely contributes to the diversification of venom phenotypes within and among species and underscores the role of modularity in facilitating rapid evolution of complex traits.
Identifiants
pubmed: 32046632
doi: 10.1186/s12864-020-6545-9
pii: 10.1186/s12864-020-6545-9
pmc: PMC7014597
doi:
Substances chimiques
Crotalid Venoms
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
147Subventions
Organisme : National Science Foundation
ID : DUE 1161228
Organisme : National Science Foundation
ID : DEB 1638879
Organisme : National Science Foundation
ID : DEB 1822417
Organisme : National Science Foundation
ID : DEB 1638902
Organisme : American Museum of Natural History
ID : Theodore Roosevelt Memorial Fund
Organisme : Explorers Club
ID : Student Grant
Organisme : Southwestern Association of Naturalists
ID : McCarley Student Research Award
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