Maternal paraben exposure triggers childhood overweight development.

Animals Child Child, Preschool Eating Female Humans Hypothalamus / metabolism Male Maternal Exposure / adverse effects Mice Mice, Inbred C57BL Overweight / etiology Parabens / adverse effects Pregnancy Prenatal Exposure Delayed Effects / etiology Preservatives, Pharmaceutical / adverse effects Pro-Opiomelanocortin / genetics Urine / chemistry Weight Gain

Journal

Nature communications
ISSN: 2041-1723
Titre abrégé: Nat Commun
Pays: England
ID NLM: 101528555

Informations de publication

Date de publication:
11 02 2020
Historique:
received: 28 06 2018
accepted: 17 12 2019
entrez: 13 2 2020
pubmed: 13 2 2020
medline: 14 4 2020
Statut: epublish

Résumé

Parabens are preservatives widely used in consumer products including cosmetics and food. Whether low-dose paraben exposure may cause adverse health effects has been discussed controversially in recent years. Here we investigate the effect of prenatal paraben exposure on childhood overweight by combining epidemiological data from a mother-child cohort with experimental approaches. Mothers reporting the use of paraben-containing cosmetic products have elevated urinary paraben concentrations. For butyl paraben (BuP) a positive association is observed to overweight within the first eight years of life with a stronger trend in girls. Consistently, maternal BuP exposure of mice induces a higher food intake and weight gain in female offspring. The effect is accompanied by an epigenetic modification in the neuronal Pro-opiomelanocortin (POMC) enhancer 1 leading to a reduced hypothalamic POMC expression. Here we report that maternal paraben exposure may contribute to childhood overweight development by altered POMC-mediated neuronal appetite regulation.

Identifiants

DOI: 10.1038/s41467-019-14202-1 PMID: 32047148 PMC: PMC7012887
pubmed: 32047148
doi: 10.1038/s41467-019-14202-1
pii: 10.1038/s41467-019-14202-1
pmc: PMC7012887
doi:

Substances chimiques

Parabens 0
Preservatives, Pharmaceutical 0
Pro-Opiomelanocortin 66796-54-1

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

561

Commentaires et corrections

Type : CommentIn

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Auteurs

Beate Leppert (B)

Department for Environmental Immunology, Helmholtz Centre for Environmental Research-UFZ, Leipzig, Germany.
ORCID: 0000-0002-5300-3331

Sandra Strunz (S)

Department for Environmental Immunology, Helmholtz Centre for Environmental Research-UFZ, Leipzig, Germany.
Department of Dermatology Venerology and Allergology, Leipzig University Medical Center, Leipzig, Germany.

Bettina Seiwert (B)

Department for Analytical Chemistry, Helmholtz Centre for Environmental Research-UFZ, Leipzig, Germany.

Linda Schlittenbauer (L)

Department for Analytical Chemistry, Helmholtz Centre for Environmental Research-UFZ, Leipzig, Germany.

Rita Schlichting (R)

Department for Cell Toxicology, Helmholtz Centre for Environmental Research-UFZ, Leipzig, Germany.

Christiane Pfeiffer (C)

Department for Environmental Immunology, Helmholtz Centre for Environmental Research-UFZ, Leipzig, Germany.

Stefan Röder (S)

Department for Environmental Immunology, Helmholtz Centre for Environmental Research-UFZ, Leipzig, Germany.
ORCID: 0000-0001-9367-663X

Mario Bauer (M)

Department for Environmental Immunology, Helmholtz Centre for Environmental Research-UFZ, Leipzig, Germany.

Michael Borte (M)

Children's Hospital, Municipal Hospital St. Georg, Leipzig, Germany.

Gabriele I Stangl (GI)

Institute of Agriculture and Nutritional Sciences, Martin Luther University Halle-Wittenberg, Halle (Saale), Germany.
Competence Cluster for Nutrition and Cardiovascular Health (nutriCARD) Halle-Jena, Leipzig, Germany.
ORCID: 0000-0001-8073-524X

Torsten Schöneberg (T)

Medical Faculty, Rudolf Schönheimer Institute of Biochemistry, University of Leipzig, Leipzig, Germany.

Angela Schulz (A)

Medical Faculty, Rudolf Schönheimer Institute of Biochemistry, University of Leipzig, Leipzig, Germany.

Isabell Karkossa (I)

Department Molecular Systems Biology, Helmholtz Centre for Environmental Research-UFZ, Leipzig, Germany.

Ulrike E Rolle-Kampczyk (UE)

Department Molecular Systems Biology, Helmholtz Centre for Environmental Research-UFZ, Leipzig, Germany.
ORCID: 0000-0002-7728-6284

Loreen Thürmann (L)

Department for Environmental Immunology, Helmholtz Centre for Environmental Research-UFZ, Leipzig, Germany.
Environmental Epigenetics and Lung Research Group, Charité-Universitätsmedizin Berlin, Berlin, Germany.
Molecular Epidemiology, Berlin Institute of Health (BIH), Berlin, Germany.
ORCID: 0000-0003-1109-1924

Martin von Bergen (M)

Department Molecular Systems Biology, Helmholtz Centre for Environmental Research-UFZ, Leipzig, Germany.
Faculty of Life Sciences, Institute of Biochemistry, University of Leipzig, Leipzig, Germany.

Beate I Escher (BI)

Department for Cell Toxicology, Helmholtz Centre for Environmental Research-UFZ, Leipzig, Germany.

Kristin M Junge (KM)

Department for Environmental Immunology, Helmholtz Centre for Environmental Research-UFZ, Leipzig, Germany.

Thorsten Reemtsma (T)

Department for Analytical Chemistry, Helmholtz Centre for Environmental Research-UFZ, Leipzig, Germany.
ORCID: 0000-0003-1606-0764

Irina Lehmann (I)

Department for Environmental Immunology, Helmholtz Centre for Environmental Research-UFZ, Leipzig, Germany. irina.lehmann@charite.de.
Environmental Epigenetics and Lung Research Group, Charité-Universitätsmedizin Berlin, Berlin, Germany. irina.lehmann@charite.de.
Molecular Epidemiology, Berlin Institute of Health (BIH), Berlin, Germany. irina.lehmann@charite.de.
ORCID: 0000-0001-8875-5587

Tobias Polte (T)

Department for Environmental Immunology, Helmholtz Centre for Environmental Research-UFZ, Leipzig, Germany. tobias.polte@ufz.de.
Department of Dermatology Venerology and Allergology, Leipzig University Medical Center, Leipzig, Germany. tobias.polte@ufz.de.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Maternal paraben exposure triggers childhood...
questionsmedicales.fr › Personnes › Tranches d'âge › Enfant › Maternal paraben exposure triggers childhood...
questionsmedicales.fr › Personnes › Tranches d'âge › Enfant › Enfant d'âge préscolaire › Maternal paraben exposure triggers childhood...
questionsmedicales.fr › Phénomènes physiologiques de l'appareil buccodentaire et de l'appareil digestif › Phénomènes physiologiques de l'appareil digestif › Consommation alimentaire › Maternal paraben exposure triggers childhood...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Maternal paraben exposure triggers childhood...
questionsmedicales.fr › Système nerveux › Système nerveux central › Encéphale › Prosencéphale › Diencéphale › Hypothalamus › Maternal paraben exposure triggers childhood...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Pollution de l'environnement › Exposition environnementale › Exposition maternelle › Maternal paraben exposure triggers childhood...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Maternal paraben exposure triggers childhood...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Lignées consanguines de souris › Souris de lignée C57BL › Maternal paraben exposure triggers childhood...
questionsmedicales.fr › Phénomènes physiologiques › Constitution physique › Apparence corporelle › Surpoids › Maternal paraben exposure triggers childhood...
questionsmedicales.fr › Composés chimiques organiques › Hydrocarbures › Hydrocarbures cycliques › Hydrocarbures aromatiques › Dérivés du benzène › Phénols › Hydroxybenzoates › Parabènes › Maternal paraben exposure triggers childhood...
questionsmedicales.fr › Phénomènes physiologiques des appareils urinaire et reproducteur › Phénomènes physiologiques de la reproduction › Reproduction › Grossesse › Maternal paraben exposure triggers childhood...
questionsmedicales.fr › Maladies urogénitales › Maladies de l'appareil urogénital féminin et complications de la grossesse › Complications de la grossesse › Lésions prénatales › Effets différés de l'exposition prénatale à des facteurs de risque › Maternal paraben exposure triggers childhood...
questionsmedicales.fr › Actions chimiques et utilisations › Utilisations spécialisées de produits chimiques › Excipients pharmaceutiques › Conservateurs pharmaceutiques › Maternal paraben exposure triggers childhood...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Précurseurs de protéines › Pro-opiomélanocortine › Maternal paraben exposure triggers childhood...
questionsmedicales.fr › Liquides et sécrétions biologiques › Liquides biologiques › Urine › Maternal paraben exposure triggers childhood...
questionsmedicales.fr › Phénomènes physiologiques › Croissance et développement › Croissance › Mensurations corporelles › Poids › Modifications du poids corporel › Prise de poids › Maternal paraben exposure triggers childhood...