Agomelatine prevents indomethacin-induced gastric ulcer in rats.
Acetamides
/ pharmacology
Animals
Anti-Inflammatory Agents, Non-Steroidal
/ toxicity
Anti-Ulcer Agents
/ pharmacology
Dose-Response Relationship, Drug
Hypnotics and Sedatives
/ pharmacology
Indomethacin
/ toxicity
Male
Oxidative Stress
/ drug effects
Random Allocation
Rats
Rats, Wistar
Reactive Oxygen Species
/ antagonists & inhibitors
Stomach Ulcer
/ chemically induced
Agomelatine
Indomethacin
Inflammation
Ulcer
Journal
Pharmacological reports : PR
ISSN: 2299-5684
Titre abrégé: Pharmacol Rep
Pays: Switzerland
ID NLM: 101234999
Informations de publication
Date de publication:
Aug 2020
Aug 2020
Historique:
received:
10
10
2019
accepted:
11
12
2019
revised:
26
10
2019
pubmed:
13
2
2020
medline:
29
5
2021
entrez:
13
2
2020
Statut:
ppublish
Résumé
Gastric ulcer is a very common gastrointestinal disease that may be dangerous and even may lead to death. The current study was conducted to detect the prophylactic effects of agomelatine on indomethacin-induced gastric ulcer. In this study, a total of 5 groups were created as the sham, ulcer, omeprazole, agomelatine 1 mg/kg and agomelatine 5 mg/kg groups. The effects of agomelatine on indomethacin-induced gastric injury were investigated. Total antioxidant and oxidant levels; the oxidant parameters like oxidative stress index and the inflammation markers such as tumor necrosis factor-α, interleukin-1β, interleukin-6 and interleukin-10 levels in stomach tissue were determined by ELISA. In addition, the gastric mucosal injury occurred in stomach wall was examined with histopathological methods. While the levels of the inflammatory markers, total oxidant status and oxidative stress index increased at an obvious level especially in the indomethacin group, the total antioxidant status levels decreased. It was observed that these parameters were improved at a significant level in agomelatine 1 mg/kg and agomelatine 5 mg/kg groups when compared to ulcer group; and the results were similar to omeprazole group. It was also observed that our histopathological findings were consistent with all our other results. The results of this study showed that agomelatine usage in indomethacin-induced gastric ulcer model provides beneficial results.
Sections du résumé
BACKGROUND
BACKGROUND
Gastric ulcer is a very common gastrointestinal disease that may be dangerous and even may lead to death. The current study was conducted to detect the prophylactic effects of agomelatine on indomethacin-induced gastric ulcer.
METHODS
METHODS
In this study, a total of 5 groups were created as the sham, ulcer, omeprazole, agomelatine 1 mg/kg and agomelatine 5 mg/kg groups. The effects of agomelatine on indomethacin-induced gastric injury were investigated. Total antioxidant and oxidant levels; the oxidant parameters like oxidative stress index and the inflammation markers such as tumor necrosis factor-α, interleukin-1β, interleukin-6 and interleukin-10 levels in stomach tissue were determined by ELISA. In addition, the gastric mucosal injury occurred in stomach wall was examined with histopathological methods.
RESULTS
RESULTS
While the levels of the inflammatory markers, total oxidant status and oxidative stress index increased at an obvious level especially in the indomethacin group, the total antioxidant status levels decreased. It was observed that these parameters were improved at a significant level in agomelatine 1 mg/kg and agomelatine 5 mg/kg groups when compared to ulcer group; and the results were similar to omeprazole group. It was also observed that our histopathological findings were consistent with all our other results.
CONCLUSIONS
CONCLUSIONS
The results of this study showed that agomelatine usage in indomethacin-induced gastric ulcer model provides beneficial results.
Identifiants
pubmed: 32048252
doi: 10.1007/s43440-019-00049-2
pii: 10.1007/s43440-019-00049-2
doi:
Substances chimiques
Acetamides
0
Anti-Inflammatory Agents, Non-Steroidal
0
Anti-Ulcer Agents
0
Hypnotics and Sedatives
0
Reactive Oxygen Species
0
agomelatine
137R1N49AD
Indomethacin
XXE1CET956
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM