Analyzing the co-localization of substantia nigra hyper-echogenicities and iron accumulation in Parkinson's disease: A multi-modal atlas study with transcranial ultrasound and MRI.

Aged Female Humans Image Interpretation, Computer-Assisted / methods Iron Magnetic Resonance Imaging / methods Male Middle Aged Multimodal Imaging / methods Neuroimaging / methods Parkinson Disease / diagnostic imaging Substantia Nigra / diagnostic imaging Ultrasonography, Doppler, Transcranial / methods
Multi-modal registration Parkinson's disease Quantitative susceptibility mapping Substantia nigra Transcranial sonography

Journal

NeuroImage. Clinical
ISSN: 2213-1582
Titre abrégé: Neuroimage Clin
Pays: Netherlands
ID NLM: 101597070

Informations de publication

Date de publication:
2020
Historique:
received: 01 09 2019
revised: 12 01 2020
accepted: 14 01 2020
pubmed: 13 2 2020
medline: 27 3 2021
entrez: 13 2 2020
Statut: ppublish

Résumé

Transcranial B-mode sonography (TCS) can detect hyperechogenic speckles in the area of the substantia nigra (SN) in Parkinson's disease (PD). These speckles correlate with iron accumulation in the SN tissue, but an exact volumetric localization in and around the SN is still unknown. Areas of increased iron content in brain tissue can be detected in vivo with magnetic resonance imaging, using quantitative susceptibility mapping (QSM). In this work, we i) acquire, co-register and transform TCS and QSM imaging from a cohort of 23 PD patients and 27 healthy control subjects into a normalized atlas template space and ii) analyze and compare the 3D spatial distributions of iron accumulation in the midbrain, as detected by a signal increase (TCS+ and QSM+) in both modalities. We achieved sufficiently accurate intra-modal target registration errors (TRE<1 mm) for all MRI volumes and multi-modal TCS-MRI co-localization (TRE<4 mm) for 66.7% of TCS scans. In the caudal part of the midbrain, enlarged TCS+ and QSM+ areas were located within the SN pars compacta in PD patients in comparison to healthy controls. More cranially, overlapping TCS+ and QSM+ areas in PD subjects were found in the area of the ventral tegmental area (VTA). Our findings are concordant with several QSM-based studies on iron-related alterations in the area SN pars compacta. They substantiate that TCS+ is an indicator of iron accumulation in Parkinson's disease within and in the vicinity of the SN. Furthermore, they are in favor of an involvement of the VTA and thereby the mesolimbic system in Parkinson's disease.

Sections du résumé

BACKGROUND
Transcranial B-mode sonography (TCS) can detect hyperechogenic speckles in the area of the substantia nigra (SN) in Parkinson's disease (PD). These speckles correlate with iron accumulation in the SN tissue, but an exact volumetric localization in and around the SN is still unknown. Areas of increased iron content in brain tissue can be detected in vivo with magnetic resonance imaging, using quantitative susceptibility mapping (QSM).
METHODS
In this work, we i) acquire, co-register and transform TCS and QSM imaging from a cohort of 23 PD patients and 27 healthy control subjects into a normalized atlas template space and ii) analyze and compare the 3D spatial distributions of iron accumulation in the midbrain, as detected by a signal increase (TCS+ and QSM+) in both modalities.
RESULTS
We achieved sufficiently accurate intra-modal target registration errors (TRE<1 mm) for all MRI volumes and multi-modal TCS-MRI co-localization (TRE<4 mm) for 66.7% of TCS scans. In the caudal part of the midbrain, enlarged TCS+ and QSM+ areas were located within the SN pars compacta in PD patients in comparison to healthy controls. More cranially, overlapping TCS+ and QSM+ areas in PD subjects were found in the area of the ventral tegmental area (VTA).
CONCLUSION
Our findings are concordant with several QSM-based studies on iron-related alterations in the area SN pars compacta. They substantiate that TCS+ is an indicator of iron accumulation in Parkinson's disease within and in the vicinity of the SN. Furthermore, they are in favor of an involvement of the VTA and thereby the mesolimbic system in Parkinson's disease.

Identifiants

DOI: 10.1016/j.nicl.2020.102185 PMID: 32050136 PMC: PMC7013333
pubmed: 32050136
pii: S2213-1582(20)30023-1
doi: 10.1016/j.nicl.2020.102185
pmc: PMC7013333
pii:
doi:

Substances chimiques

Iron E1UOL152H7

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

102185

Informations de copyright

Copyright © 2020 The Author(s). Published by Elsevier Inc. All rights reserved.

Déclaration de conflit d'intérêts

Declaration of Competing Interest None.

Références

Brain Struct Funct. 2012 Apr;217(2):591-612
pubmed: 21935672
Adv Neurol. 1993;60:259-66
pubmed: 8380520
Mov Disord. 2016 Mar;31(3):302-9
pubmed: 26362398
BMC Bioinformatics. 2017 May 26;18(1):281
pubmed: 28549410
J Neurol Sci. 2019 Feb 15;397:16-21
pubmed: 30579060
J Neural Transm. 1988;74(3):199-205
pubmed: 3210014
Parkinsonism Relat Disord. 2017 Sep;42:1-11
pubmed: 28647434
Synapse. 2007 Feb;61(2):87-95
pubmed: 17117419
Mov Disord. 2019 Jul;34(7):1006-1013
pubmed: 31180615
Neuroscience. 2014 Dec 12;282:60-8
pubmed: 24875175
Mov Disord. 2016 Mar;31(3):317-24
pubmed: 26362242
Med Image Comput Comput Assist Interv. 2011;14(Pt 3):362-9
pubmed: 22003720
Brain. 1991 Aug;114 ( Pt 4):1953-75
pubmed: 1832073
Neurology. 1995 Jan;45(1):182-4
pubmed: 7824114
Neuroimage. 2014 Oct 15;100:580-9
pubmed: 24979343
Annu Int Conf IEEE Eng Med Biol Soc. 2012;2012:1129-32
pubmed: 23366095
J Neural Transm Suppl. 2006;(71):123-32
pubmed: 17447423
Sci Rep. 2016 Feb 16;6:20863
pubmed: 26878893
J Neurol Sci. 2016 May 15;364:9-11
pubmed: 27084206
Brain. 1999 Aug;122 ( Pt 8):1437-48
pubmed: 10430830
Neuroimage. 2010 Feb 1;49(3):2457-66
pubmed: 19818860
Exp Neurol. 2001 May;169(1):163-81
pubmed: 11312569
Ultrasound Med Biol. 2012 Dec;38(12):2041-50
pubmed: 23196201
Arch Neurol. 2011 Jul;68(7):932-7
pubmed: 21747034
Basal Ganglia. 2015 Aug 1;5(2-3):51-55
pubmed: 26251824
J Neurochem. 1994 Sep;63(3):793-807
pubmed: 7519659
Eur J Neurol. 2013 Jan;20(1):16-34
pubmed: 23279440
Brain Behav. 2012 May;2(3):231-6
pubmed: 22741096
AJNR Am J Neuroradiol. 2015 Jun;36(6):1102-8
pubmed: 25767187
J Magn Reson Imaging. 2012 Jan;35(1):48-55
pubmed: 21987471
Med Image Anal. 2012 Apr;16(3):687-703
pubmed: 21216180
J Neurol Neurosurg Psychiatry. 2010 Oct;81(10):1087-92
pubmed: 20543186
IEEE Trans Med Imaging. 2002 Dec;21(12):1445-9
pubmed: 12588028
Arch Neurol. 2002 Jun;59(6):999-1005
pubmed: 12056937
J Magn Reson Imaging. 2016 Jul;44(1):59-71
pubmed: 26695834
Hum Brain Mapp. 2002 Nov;17(3):143-55
pubmed: 12391568
Lancet. 1987 Nov 21;2(8569):1219-20
pubmed: 2890848
J Parkinsons Dis. 2011;1(2):205-16
pubmed: 23934922
Neurobiol Dis. 2006 Sep;23(3):522-32
pubmed: 16806952
Neuroimage. 2012 Aug 15;62(2):782-90
pubmed: 21979382
Front Neuroanat. 2019 Jul 03;13:68
pubmed: 31333421
Med Image Comput Comput Assist Interv. 2013;16(Pt 1):34-41
pubmed: 24505646
IEEE Trans Med Imaging. 2011 Nov;30(11):1901-20
pubmed: 21632295
J Neurol Neurosurg Psychiatry. 1992 Mar;55(3):181-4
pubmed: 1564476
IEEE Trans Ultrason Ferroelectr Freq Control. 2006 Aug;53(8):1432-9
pubmed: 16921895
IEEE Trans Med Imaging. 2015 Oct;34(10):1993-2024
pubmed: 25494501
Neuroimage. 2011 Feb 14;54(4):2789-807
pubmed: 21040794
Mov Disord. 2007 Feb 15;22(3):334-40
pubmed: 17149719
Arch Neurol. 2007 Nov;64(11):1635-40
pubmed: 17998447
Biomed Res Int. 2014;2014:581256
pubmed: 24527451
Exp Neurol. 1997 Mar;144(1):202-13
pubmed: 9126172
Int J Comput Assist Radiol Surg. 2015 Jun;10(6):891-900
pubmed: 25861056
Med Image Comput Comput Assist Interv. 2006;9(Pt 2):750-7
pubmed: 17354840
Brain. 2017 Jan;140(1):118-131
pubmed: 27836833
Eur J Nucl Med Mol Imaging. 2016 May;43(5):911-924
pubmed: 26567163
J Neurol Sci. 2018 Mar 15;386:46-52
pubmed: 29406966
Neuroimage. 2015 May 1;111:622-30
pubmed: 25731991
Magn Reson Imaging. 2015 Jun;33(5):559-65
pubmed: 25721997
IEEE Trans Med Imaging. 2006 Nov;25(11):1451-61
pubmed: 17117774
Magn Reson Med. 1994 Sep;32(3):330-4
pubmed: 7984065
Neuroimage. 2008 Apr 1;40(2):551-558
pubmed: 18222095
Front Neuroanat. 2015 May 19;9:59
pubmed: 26042000
Neuroimage. 2009 Jul 1;46(3):786-802
pubmed: 19195496
Med Image Comput Comput Assist Interv. 2012;15(Pt 3):443-50
pubmed: 23286161
Med Image Anal. 2013 Dec;17(8):1137-50
pubmed: 23969169
Mov Disord. 2013 Feb;28(2):216-9
pubmed: 23115051
Neuroimage. 2012 Sep;62(3):1593-9
pubmed: 22634862
Neuroimage. 2006 Jul 1;31(3):1116-28
pubmed: 16545965
Ultrasound Med Biol. 1999 Jul;25(6):901-4
pubmed: 10461717
Mov Disord. 2012 Mar;27(3):450-3
pubmed: 22237792
Med Image Anal. 2014 Dec;18(8):1312-9
pubmed: 24842859

Auteurs

Seyed-Ahmad Ahmadi (SA)

Department of Neurology, Ludwig-Maximilians University, Marchioninistraße 15, Munich 81377, Germany; German Center for Vertigo and Balance Disorders (DSGZ), Ludwig-Maximilians University, Marchioninistraße 15, Munich 81377, Germany; Chair for Computer Aided Medical Procedures (CAMP), Technical University of Munich, Boltzmannstr. 3, Garching 85748, Germany.

Kai Bötzel (K)

Department of Neurology, Ludwig-Maximilians University, Marchioninistraße 15, Munich 81377, Germany.

Johannes Levin (J)

Department of Neurology, Ludwig-Maximilians University, Marchioninistraße 15, Munich 81377, Germany.

Juliana Maiostre (J)

Department of Neurology, Ludwig-Maximilians University, Marchioninistraße 15, Munich 81377, Germany.

Tassilo Klein (T)

SAP ML Research, Berlin, Germany.

Wolfgang Wein (W)

ImFusion GmbH, Agnes-Pockels-Bogen 1, München 80992, Germany.

Verena Rozanski (V)

Klinik Haag i. OB, Haag i. OB 83527, Germany.

Olaf Dietrich (O)

Department of Radiology, Ludwig-Maximilians University, Marchioninistr. 15, Munich 81377, Germany.

Birgit Ertl-Wagner (B)

Department of Radiology, Ludwig-Maximilians University, Marchioninistr. 15, Munich 81377, Germany; The Hospital for Sick Children, 555 University Avenue, Toronto, Ontario M5G 1 × 8, Canada.

Nassir Navab (N)

Chair for Computer Aided Medical Procedures (CAMP), Technical University of Munich, Boltzmannstr. 3, Garching 85748, Germany.

Annika Plate (A)

Department of Neurology, Ludwig-Maximilians University, Marchioninistraße 15, Munich 81377, Germany. Electronic address: Annika.plate@med.uni-muenchen.de.

Articles similaires

[Redispensing of expensive oral anticancer medicines: a practical application].

Lisanne N van Merendonk, Kübra Akgöl, Bastiaan Nuijen
1.00
Humans Antineoplastic Agents Administration, Oral Drug Costs Counterfeit Drugs

Smoking Cessation and Incident Cardiovascular Disease.

Jun Hwan Cho, Seung Yong Shin, Hoseob Kim et al.
1.00
Humans Male Smoking Cessation Cardiovascular Diseases Female

Evaluation of Low-Value Services Across Major Medicare Advantage Insurers and Traditional Medicare.

Ciara Duggan, Adam L Beckman, Ishani Ganguli et al.
1.00
Humans United States Aged Cross-Sectional Studies Medicare Part C

Effectiveness of Virtual Yoga for Chronic Low Back Pain: A Randomized Clinical Trial.

Hallie Tankha, Devyn Gaskins, Amanda Shallcross et al.
1.00
Humans Yoga Low Back Pain Female Male

Classifications MeSH

questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Sujet âgé › Analyzing the co-localization of substantia...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Analyzing the co-localization of substantia...
questionsmedicales.fr › Sciences de l'information › Informatique › Informatique médicale › Applications de l'informatique médicale › Prise de décision assistée par ordinateur › Diagnostic assisté par ordinateur › Interprétation d'images assistée par ordinateur › Analyzing the co-localization of substantia...
questionsmedicales.fr › Produits chimiques inorganiques › Métaux › Métaux lourds › Fer › Analyzing the co-localization of substantia...
questionsmedicales.fr › Diagnostic › Techniques et procédures diagnostiques › Imagerie diagnostique › Tomographie › Imagerie par résonance magnétique › Analyzing the co-localization of substantia...
questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Adulte d'âge moyen › Analyzing the co-localization of substantia...
questionsmedicales.fr › Diagnostic › Techniques et procédures diagnostiques › Imagerie diagnostique › Imagerie multimodale › Analyzing the co-localization of substantia...
questionsmedicales.fr › Techniques d'investigation › Neuroimagerie › Analyzing the co-localization of substantia...
questionsmedicales.fr › Maladies du système nerveux › Maladies neurodégénératives › Maladie de Parkinson › Analyzing the co-localization of substantia...
questionsmedicales.fr › Système nerveux › Système nerveux central › Encéphale › Tronc cérébral › Mésencéphale › Pédoncule cérébral › Substantia nigra › Analyzing the co-localization of substantia...
questionsmedicales.fr › Techniques d'investigation › Neuroimagerie › Neuroradiographie › Échoencéphalographie › Échographie-doppler transcrânienne › Analyzing the co-localization of substantia...