BGN/TLR4/NF-B Mediates Epigenetic Silencing of Immunosuppressive Siglec Ligands in Colon Cancer Cells.
Base Sequence
Biglycan
/ metabolism
Carcinogenesis
/ pathology
Cell Line, Tumor
Colonic Neoplasms
/ genetics
Epigenesis, Genetic
Gene Silencing
Humans
Immunosuppression Therapy
Ligands
NF-kappa B
/ metabolism
Polycomb Repressive Complex 2
/ metabolism
Promoter Regions, Genetic
/ genetics
Sialic Acid Binding Immunoglobulin-like Lectins
/ metabolism
Sialyltransferases
/ genetics
Sulfate Transporters
/ genetics
Toll-Like Receptor 4
/ metabolism
BGN
NF-B
SLC26A2
ST6GalNAc6
Siglec-7
TLR
disialyl Lewisa
sialyl 6-sulfo Lewisx
Journal
Cells
ISSN: 2073-4409
Titre abrégé: Cells
Pays: Switzerland
ID NLM: 101600052
Informations de publication
Date de publication:
09 02 2020
09 02 2020
Historique:
received:
30
12
2019
revised:
06
02
2020
accepted:
06
02
2020
entrez:
14
2
2020
pubmed:
14
2
2020
medline:
11
2
2021
Statut:
epublish
Résumé
Human Toll-like receptor (TLR) signaling plays a vital role in intestinal inflammation by activating the NF-B pathway. By querying GENT2 datasets, we identified the gene expression level of TLR2 and TLR4 as being substantially increased in colorectal cancer. Introduction of shRNAs for TLR4 but not TLR2 dramatically recovered disialyl Lewis
Identifiants
pubmed: 32050430
pii: cells9020397
doi: 10.3390/cells9020397
pmc: PMC7072454
pii:
doi:
Substances chimiques
BGN protein, human
0
Biglycan
0
Ligands
0
NF-kappa B
0
SLC26A2 protein, human
0
Sialic Acid Binding Immunoglobulin-like Lectins
0
Sulfate Transporters
0
Toll-Like Receptor 4
0
Polycomb Repressive Complex 2
EC 2.1.1.43
GalNAc sialyltransferase VI
EC 2.4.99.-
Sialyltransferases
EC 2.4.99.-
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Déclaration de conflit d'intérêts
The authors declare no conflict of interest.
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