Obesity Reduces Maternal Blood Triglyceride Concentrations by Reducing Angiopoietin-Like Protein 4 Expression in Mice.
Journal
Diabetes
ISSN: 1939-327X
Titre abrégé: Diabetes
Pays: United States
ID NLM: 0372763
Informations de publication
Date de publication:
06 2020
06 2020
Historique:
received:
22
11
2019
accepted:
07
02
2020
pubmed:
14
2
2020
medline:
23
10
2020
entrez:
14
2
2020
Statut:
ppublish
Résumé
To ensure fetal lipid supply, maternal blood triglyceride (TG) concentrations are robustly elevated during pregnancy. Interestingly, a lower increase in maternal blood TG concentrations has been observed in some obese mothers. We have shown that high-fat (HF) feeding during pregnancy significantly reduces maternal blood TG levels. Therefore, we performed this study to investigate if and how obesity alters maternal blood TG levels. Maternal obesity was established by prepregnant HF (ppHF) feeding, which avoided the dietary effect during pregnancy. We found not only that maternal blood TG concentrations in ppHF dams were remarkably lower than in control dams but also that the TG peak occurred earlier during gestation. Hepatic TG production and intestinal TG absorption were unchanged in ppHF dams, but systemic lipoprotein lipase (LPL) activity was increased, suggesting that increased blood TG clearance contributes to the decreased blood TG concentrations in ppHF dams. Although significantly higher levels of UCP1 protein were observed in interscapular brown adipose tissue (iBAT) of ppHF dams,
Identifiants
pubmed: 32051149
pii: db19-1181
doi: 10.2337/db19-1181
pmc: PMC7243287
doi:
Substances chimiques
Angiopoietin-Like Protein 4
0
Angptl4 protein, mouse
0
Dietary Fats
0
Triglycerides
0
Ucp1 protein, mouse
0
Uncoupling Protein 1
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1100-1109Subventions
Organisme : NIDDK NIH HHS
ID : R01 DK095132
Pays : United States
Organisme : NIDDK NIH HHS
ID : R01 DK113007
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL130146
Pays : United States
Commentaires et corrections
Type : CommentIn
Informations de copyright
© 2020 by the American Diabetes Association.
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