Department of Molecular Genetics, Graduate School of Medical Sciences, Kumamoto University, 1-1-1 Honjo, Chuo-ku, Kumamoto, Japan.
Center for Metabolic Regulation of Healthy Aging (CMHA), Graduate School of Medical Sciences, Kumamoto University, 1-1-1 Honjo, Chuo-ku, Kumamoto, Japan.
Core Research for Evolutional Science and Technology (CREST), Japan Agency for Medical Research and Development (AMED), 1-7-1 Otemachi, Chiyoda-ku, Tokyo, Japan.
Publications dans "Protéines semblables à l'angiopoïétine" :
Department of Biochemistry and Molecular Biology, Fraternal Order of Eagles Diabetes Research Center, and Obesity Research and Education Initiative, University of Iowa, Iowa City, IA, USA. Electronic address: Brandon-davies@uiowa.edu.
Publications dans "Protéines semblables à l'angiopoïétine" :
Department of Molecular Genetics, Graduate School of Medical Sciences, Kumamoto University, 1-1-1 Honjo, Chuo-ku, Kumamoto, Japan.
Center for Metabolic Regulation of Healthy Aging (CMHA), Graduate School of Medical Sciences, Kumamoto University, 1-1-1 Honjo, Chuo-ku, Kumamoto, Japan.
Publications dans "Protéines semblables à l'angiopoïétine" :
Department of Biochemistry and Molecular Biology, Fraternal Order of Eagles Diabetes Research Center, and Obesity Research and Education Initiative, University of Iowa, Iowa City, IA, USA.
Publications dans "Protéines semblables à l'angiopoïétine" :
Beijing Anzhen Hospital, Capital Medical University, The Key Laboratory of Upper Airway Dysfunction-related Cardiovascular Diseases, Beijing, 10029, China; Beijing Anzhen Hospital, Capital Medical University, The Key Laboratory of Remodeling-Related Cardiovascular Diseases, Ministry of Education, Beijing, 100029, China; Beijing Institute of Heart Lung and Blood Vessel Disease, Beijing, 100029, China.
Publications dans "Protéines semblables à l'angiopoïétine" :
Beijing Anzhen Hospital, Capital Medical University, The Key Laboratory of Upper Airway Dysfunction-related Cardiovascular Diseases, Beijing, 10029, China; Beijing Anzhen Hospital, Capital Medical University, The Key Laboratory of Remodeling-Related Cardiovascular Diseases, Ministry of Education, Beijing, 100029, China; Beijing Institute of Heart Lung and Blood Vessel Disease, Beijing, 100029, China.
Publications dans "Protéines semblables à l'angiopoïétine" :
Beijing Anzhen Hospital, Capital Medical University, The Key Laboratory of Upper Airway Dysfunction-related Cardiovascular Diseases, Beijing, 10029, China; Beijing Anzhen Hospital, Capital Medical University, The Key Laboratory of Remodeling-Related Cardiovascular Diseases, Ministry of Education, Beijing, 100029, China; Beijing Institute of Heart Lung and Blood Vessel Disease, Beijing, 100029, China.
Publications dans "Protéines semblables à l'angiopoïétine" :
Beijing Anzhen Hospital, Capital Medical University, The Key Laboratory of Upper Airway Dysfunction-related Cardiovascular Diseases, Beijing, 10029, China; Beijing Anzhen Hospital, Capital Medical University, The Key Laboratory of Remodeling-Related Cardiovascular Diseases, Ministry of Education, Beijing, 100029, China; Beijing Institute of Heart Lung and Blood Vessel Disease, Beijing, 100029, China.
Publications dans "Protéines semblables à l'angiopoïétine" :
Beijing Anzhen Hospital, Capital Medical University, The Key Laboratory of Upper Airway Dysfunction-related Cardiovascular Diseases, Beijing, 10029, China; Beijing Anzhen Hospital, Capital Medical University, The Key Laboratory of Remodeling-Related Cardiovascular Diseases, Ministry of Education, Beijing, 100029, China; Beijing Institute of Heart Lung and Blood Vessel Disease, Beijing, 100029, China.
Publications dans "Protéines semblables à l'angiopoïétine" :
Beijing Anzhen Hospital, Capital Medical University, The Key Laboratory of Upper Airway Dysfunction-related Cardiovascular Diseases, Beijing, 10029, China; Beijing Anzhen Hospital, Capital Medical University, The Key Laboratory of Remodeling-Related Cardiovascular Diseases, Ministry of Education, Beijing, 100029, China; Beijing Institute of Heart Lung and Blood Vessel Disease, Beijing, 100029, China.
Publications dans "Protéines semblables à l'angiopoïétine" :
Beijing Anzhen Hospital, Capital Medical University, The Key Laboratory of Upper Airway Dysfunction-related Cardiovascular Diseases, Beijing, 10029, China; Beijing Anzhen Hospital, Capital Medical University, The Key Laboratory of Remodeling-Related Cardiovascular Diseases, Ministry of Education, Beijing, 100029, China; Beijing Institute of Heart Lung and Blood Vessel Disease, Beijing, 100029, China. Electronic address: qinyanwen@ccmu.edu.cn.
Publications dans "Protéines semblables à l'angiopoïétine" :
The aim of this study was to discuss the potential mechanisms and implications of the opposing liver safety results from recent angiopoietin-like 3 (ANGPTL3) inhibition studies....
The clinical development of vupanorsen, a N-acetylgalactosamine (GalNAc) antisense targeting hepatic ANGPTL3, was recently discontinued due to a significant signal of liver transaminase increase. Vupa...
ANGPTL3 inhibition is an attractive therapeutic target to reduce all apoB-containing lipoproteins. The discrepancy in liver signal results between the antisense and siRNA approach may be explained by ...
Angiopoietin-like proteins (ANGPTL) constitute a family of eight proteins (1-8) which play a pivotal role in the regulation of various pathophysiological processes. The current study sought to identif...
Background ANGPTL3 (angiopoietin-like protein 3) is an acknowledged crucial regulator of lipid metabolism by virtue of its inhibitory effect on lipoprotein lipase and endothelial lipase. It is current...
Angiopoietins are crucial growth factors for maintaining a healthy, functional endothelium. Patients with type 2 diabetes (T2D) exhibit significant levels of angiogenic markers, particularly Angiopoie...
Non-alcoholic fatty liver disease (NAFLD) is the most frequent cause of chronic liver disease, with a range of conditions including non-alcoholic fatty liver, non-alcoholic steatohepatitis, cirrhosis,...
Acute myocardial infarction is mainly caused by a lack of blood flood in the coronary artery. Angiopoietin-like protein 2 (ANGPTL2) induces platelet activation and thrombus formation in vitro through ...
The angiopoietin-like (ANGPTL) proteins ANGPTL3 and ANGPTL4 are critical lipoprotein lipase (LPL) inhibitors. This review discusses the unique ability of the insulin-responsive protein ANGPTL8 to regu...
After feeding, ANGPTL4/8 acts locally in adipose tissue, has decreased LPL-inhibitory activity compared to ANGPTL4, and binds tissue plasminogen activator (tPA) and plasminogen to generate plasmin, wh...
ANGPTL8 plays a crucial role in TG metabolism by forming ANGPTL3/8 and ANGPTL4/8 complexes that differentially modulate LPL activities in oxidative and adipose tissues respectively. Selective ANGPTL8 ...
RNA-based, antibody-based, and genome editing-based therapies are currently under investigation to determine if the inhibition of angiopoietin-like protein-3 (ANGPTL3) could reduce lipoprotein-lipid l...
RNA sequencing of 246 explanted liver samples and genome-wide genotyping was performed to identify single-nucleotide polymorphisms (SNPs) associated with liver expression of ANGPTL3. Genome-wide summa...
In two-sample MR studies, common genetic variants influencing ANGPTL3 hepatic or blood expression levels of ANGPTL3 had a very strong effect on plasma triglyceride levels, a more modest effect on low-...
PTVs influencing ANGPTL3 protein structure as well as common genetic variants influencing ANGPTL3 hepatic expression and/or blood protein levels exhibit a strong effect on circulating plasma triglycer...
Despite the best pharmacologic tools available, cardiovascular diseases (CVDs) remain a major cause of morbidity and mortality in developed countries. After 2 decades of research, new therapeutic targ...
High levels of HDL-C are correlated with a decreased risk of cardiovascular disease. HDL-C levels are modulated in part by the secreted phospholipase, endothelial lipase (EL), which hydrolyzes the pho...
