Investigating the Role of Myeloperoxidase and Angiopoietin-like Protein 6 in Obesity and Diabetes.
Journal
Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288
Informations de publication
Date de publication:
10 04 2020
10 04 2020
Historique:
received:
07
10
2019
accepted:
02
03
2020
entrez:
12
4
2020
pubmed:
12
4
2020
medline:
15
12
2020
Statut:
epublish
Résumé
Myeloperoxidase (MPO) is positively associated with obesity and diet-induced insulin resistance. Angiopoietin-like protein 6 (ANGPTL6) regulates metabolic processes and counteract obesity through increased energy expenditure. This study aims to evaluate the plasma MPO and ANGPTL6 levels in obese and diabetic individuals as well as MPO association with biochemical markers of obesity. A total of 238 participants were enrolled, including 137 control and 101 type 2 diabetes (T2D) patients. ANGPTL6 and MPO levels and other biomarkers were measured via ELISA. ANGPTL6 levels were significantly higher in the diabetic population and obese individuals. When the group was stratified based on T2D, ANGPTL6 levels were significantly higher in obese-diabetic participants compared with non-obese-diabetics, but obese-non-diabetic individuals had similar ANGPTL6 levels to their controls. MPO levels were higher in obese compared with non-obese participants but did not differ between T2D and control participants. MPO levels were upregulated in obese compared with non-obese in both diabetics and non-diabetics. MPO was positively associated with ANGPTL6, triglyceride, BMI, TNF-alpha, high-sensitivity C-reactive protein, interleukin-6, and plasminogen activator inhibitor-1. Taken together, our findings suggest that both MPO and ANGPTL6 may regulate obesity, although MPO exerts this effect independent of diabetes while ANGPTL6 may have a modulatory role in diabetes.
Identifiants
pubmed: 32277104
doi: 10.1038/s41598-020-63149-7
pii: 10.1038/s41598-020-63149-7
pmc: PMC7148302
doi:
Substances chimiques
ANGPTL6 protein, human
0
Angiopoietin-Like Protein 6
0
Angiopoietin-like Proteins
0
Biomarkers
0
MPO protein, human
EC 1.11.1.7
Peroxidase
EC 1.11.1.7
Types de publication
Journal Article
Observational Study
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
6170Références
J Lipid Res. 2017 Jun;58(6):1166-1173
pubmed: 28413163
Diabetes Metab J. 2015 Feb;39(1):59-65
pubmed: 25729714
Int J Hematol. 2001 Aug;74(2):125-33
pubmed: 11594511
Obes Res Clin Pract. 2015 Sep-Oct;9(5):435-47
pubmed: 25979684
J Biol Chem. 2012 Feb 24;287(9):6375-86
pubmed: 22219194
J Am Coll Cardiol. 2007 Jul 10;50(2):159-65
pubmed: 17616301
J Periodontol. 2008 Aug;79(8 Suppl):1527-34
pubmed: 18673007
Nat Med. 2005 Apr;11(4):400-8
pubmed: 15778720
Mol Nutr Food Res. 2018 May;62(10):e1800060
pubmed: 29536615
Am J Kidney Dis. 2006 Jul;48(1):59-68
pubmed: 16797387
Front Endocrinol (Lausanne). 2019 Jul 24;10:495
pubmed: 31396158
Mol Metab. 2014 May 28;3(5):531-43
pubmed: 25061558
BMJ Open Diabetes Res Care. 2014 Dec 03;2(1):e000034
pubmed: 25512873
Med Sci Monit. 2008 Aug;14(8):CR406-10
pubmed: 18667997
Dis Markers. 2015;2015:357279
pubmed: 26106251
Diabetes. 2004 Nov;53(11):2950-9
pubmed: 15504976
Diabetes. 2014 Dec;63(12):4172-85
pubmed: 25024373
Metabolism. 2009 Apr;58(4):547-51
pubmed: 19303977
Ginekol Pol. 2012 Oct;83(10):749-53
pubmed: 23383560
Diabetologia. 2007 Jun;50(6):1127-39
pubmed: 17393135
Diabetol Metab Syndr. 2015 Dec 30;7:119
pubmed: 26719776
Horm Metab Res. 2014 Sep;46(10):685-90
pubmed: 25011017
Diabetes Metab J. 2019 Aug;43(4):521-529
pubmed: 30968619
Atherosclerosis. 2010 May;210(1):194-8
pubmed: 19962701
Metabolism. 2011 Apr;60(4):564-8
pubmed: 20673930
J Lipid Res. 2008 Sep;49(9):1894-903
pubmed: 18503031
Eur J Intern Med. 2006 Jan;17(1):38-42
pubmed: 16378884
Circulation. 2003 Sep 23;108(12):1440-5
pubmed: 12952835
Obesity (Silver Spring). 2009 Nov;17(11):2014-8
pubmed: 19390527
Diabetes Metab Syndr. 2019 Jan - Feb;13(1):396-400
pubmed: 30641731
Diabetes Care. 1992 Aug;15(8):1050-2
pubmed: 1324143
Metabolism. 2008 Feb;57(2):262-7
pubmed: 18191058
J Pharmacol Exp Ther. 2007 Dec;323(3):787-93
pubmed: 17804676
Nutr Metab Cardiovasc Dis. 2009 Nov;19(9):613-9
pubmed: 19201174
J Atheroscler Thromb. 2010 Apr 30;17(4):332-41
pubmed: 20124732
Blood. 2004 May 15;103(10):3760-5
pubmed: 14764539
Diabetol Metab Syndr. 2014 Mar 04;6(1):30
pubmed: 24594096
Int J Rehabil Res. 2016 Mar;39(1):63-9
pubmed: 26579698
Diabetes Care. 2012 Nov;35(11):2373-6
pubmed: 22912422
Diabetes Metab Syndr. 2016 Apr-Jun;10(2 Suppl 1):S123-6
pubmed: 27016886
Trends Cardiovasc Med. 2008 Jan;18(1):6-14
pubmed: 18206803
Trends Endocrinol Metab. 2014 Mar;25(3):146-55
pubmed: 24397894
Proc Natl Acad Sci U S A. 2003 Aug 5;100(16):9494-9
pubmed: 12871997
Clin Chim Acta. 2011 Sep 18;412(19-20):1891-2
pubmed: 21693110
Circulation. 2004 Aug 31;110(9):1134-9
pubmed: 15326065
Diabetes Care. 2007 Jun;30(6):1562-6
pubmed: 17372155
Br J Pharmacol. 2005 Sep;146(2):268-79
pubmed: 15997235
Physiol Behav. 2006 Jun 30;88(3):249-56
pubmed: 16782141
Diabetes. 2017 Feb;66(2):241-255
pubmed: 27980006
PLoS One. 2017 Mar 6;12(3):e0173024
pubmed: 28264047
Endocrine. 2016 May;52(2):187-93
pubmed: 26754661
Nat Rev Immunol. 2011 Feb;11(2):98-107
pubmed: 21233852
Dis Markers. 2015;2015:761939
pubmed: 26451069
Endocr Res. 2017 Feb;42(1):22-30
pubmed: 27135654
Nat Med. 2012 Sep;18(9):1407-12
pubmed: 22863787
J Med Biochem. 2017 Oct 28;36(4):366-374
pubmed: 30581334
J Cell Biochem. 2009 Mar 1;106(4):729-37
pubmed: 19173302
Arterioscler Thromb Vasc Biol. 2005 Jun;25(6):1102-11
pubmed: 15790935
J Mol Med (Berl). 1998 Sep;76(10):676-81
pubmed: 9766845
Front Endocrinol (Lausanne). 2014 Jan 23;5:4
pubmed: 24478758
J Clin Invest. 2003 Dec;112(12):1796-808
pubmed: 14679176
Diabetes. 2007 Apr;56(4):1010-3
pubmed: 17287468
Cell Metab. 2014 May 6;19(5):821-35
pubmed: 24807222
Diabetes. 2014 Dec;63(12):4001-3
pubmed: 25414015
Bull Exp Biol Med. 2012 Nov;154(1):23-6
pubmed: 23330081
Cardiovasc Diabetol. 2014 Apr 09;13:76
pubmed: 24716628
Lipids Health Dis. 2016 Oct 13;15(1):181
pubmed: 27733177