Beijing Anzhen Hospital, Capital Medical University, The Key Laboratory of Upper Airway Dysfunction-related Cardiovascular Diseases, Beijing, 10029, China; Beijing Anzhen Hospital, Capital Medical University, The Key Laboratory of Remodeling-Related Cardiovascular Diseases, Ministry of Education, Beijing, 100029, China; Beijing Institute of Heart Lung and Blood Vessel Disease, Beijing, 100029, China.
Publications dans "Protéine-8 de type angiopoïétine" :
Beijing Anzhen Hospital, Capital Medical University, The Key Laboratory of Upper Airway Dysfunction-related Cardiovascular Diseases, Beijing, 10029, China; Beijing Anzhen Hospital, Capital Medical University, The Key Laboratory of Remodeling-Related Cardiovascular Diseases, Ministry of Education, Beijing, 100029, China; Beijing Institute of Heart Lung and Blood Vessel Disease, Beijing, 100029, China.
Publications dans "Protéine-8 de type angiopoïétine" :
Beijing Anzhen Hospital, Capital Medical University, The Key Laboratory of Upper Airway Dysfunction-related Cardiovascular Diseases, Beijing, 10029, China; Beijing Anzhen Hospital, Capital Medical University, The Key Laboratory of Remodeling-Related Cardiovascular Diseases, Ministry of Education, Beijing, 100029, China; Beijing Institute of Heart Lung and Blood Vessel Disease, Beijing, 100029, China.
Publications dans "Protéine-8 de type angiopoïétine" :
Beijing Anzhen Hospital, Capital Medical University, The Key Laboratory of Upper Airway Dysfunction-related Cardiovascular Diseases, Beijing, 10029, China; Beijing Anzhen Hospital, Capital Medical University, The Key Laboratory of Remodeling-Related Cardiovascular Diseases, Ministry of Education, Beijing, 100029, China; Beijing Institute of Heart Lung and Blood Vessel Disease, Beijing, 100029, China.
Publications dans "Protéine-8 de type angiopoïétine" :
Beijing Anzhen Hospital, Capital Medical University, The Key Laboratory of Upper Airway Dysfunction-related Cardiovascular Diseases, Beijing, 10029, China; Beijing Anzhen Hospital, Capital Medical University, The Key Laboratory of Remodeling-Related Cardiovascular Diseases, Ministry of Education, Beijing, 100029, China; Beijing Institute of Heart Lung and Blood Vessel Disease, Beijing, 100029, China.
Publications dans "Protéine-8 de type angiopoïétine" :
Beijing Anzhen Hospital, Capital Medical University, The Key Laboratory of Upper Airway Dysfunction-related Cardiovascular Diseases, Beijing, 10029, China; Beijing Anzhen Hospital, Capital Medical University, The Key Laboratory of Remodeling-Related Cardiovascular Diseases, Ministry of Education, Beijing, 100029, China; Beijing Institute of Heart Lung and Blood Vessel Disease, Beijing, 100029, China.
Publications dans "Protéine-8 de type angiopoïétine" :
Beijing Anzhen Hospital, Capital Medical University, The Key Laboratory of Upper Airway Dysfunction-related Cardiovascular Diseases, Beijing, 10029, China; Beijing Anzhen Hospital, Capital Medical University, The Key Laboratory of Remodeling-Related Cardiovascular Diseases, Ministry of Education, Beijing, 100029, China; Beijing Institute of Heart Lung and Blood Vessel Disease, Beijing, 100029, China. Electronic address: qinyanwen@ccmu.edu.cn.
Publications dans "Protéine-8 de type angiopoïétine" :
Department of Biochemistry and Molecular Biology, Fraternal Order of Eagles Diabetes Research Center, and Obesity Research and Education Initiative, University of Iowa, Iowa City, IA, USA.
Publications dans "Protéine-8 de type angiopoïétine" :
Department of Biochemistry and Molecular Biology, Fraternal Order of Eagles Diabetes Research Center, and Obesity Research and Education Initiative, University of Iowa, Iowa City, IA, USA. Electronic address: Brandon-davies@uiowa.edu.
Publications dans "Protéine-8 de type angiopoïétine" :
Plasma levels of angiopoietin-like protein 8 (ANGPTL8) are regulated by feeding and they increase following glucose ingestion. Because both plasma glucose and insulin increase following food ingestion...
ANGPTL8 levels were measured in 30 subjects, 14 with impaired fasting glucose (IFG), and 16 with normal fasting glucose (NFG); the subjects received 75g glucose oral Glucose tolerance test (OGTT), mul...
Subjects with IFG had significantly higher ANGPTL8 than NGT subjects during the fasting state (p < 0.05). During the OGTT, plasma ANGPTL8 concentration increased by 62% above the fasting level (p < 0....
In response to nutrient ingestion, ANGPTL8 level increased due to increased plasma insulin concentration, not to the rise in plasma glucose. The incremental increase above baseline in plasma ANGLPTL8 ...
Angiopoietin-like proteins (ANGPTL) constitute a family of eight proteins (1-8) which play a pivotal role in the regulation of various pathophysiological processes. The current study sought to identif...
The angiopoietin-like (ANGPTL) proteins ANGPTL3 and ANGPTL4 are critical lipoprotein lipase (LPL) inhibitors. This review discusses the unique ability of the insulin-responsive protein ANGPTL8 to regu...
After feeding, ANGPTL4/8 acts locally in adipose tissue, has decreased LPL-inhibitory activity compared to ANGPTL4, and binds tissue plasminogen activator (tPA) and plasminogen to generate plasmin, wh...
ANGPTL8 plays a crucial role in TG metabolism by forming ANGPTL3/8 and ANGPTL4/8 complexes that differentially modulate LPL activities in oxidative and adipose tissues respectively. Selective ANGPTL8 ...
The role of the inhibition of ANGPTL3 in severe or refractory hypercholesterolemia is well documented, less in severe hyperTG. This review focuses on the preclinical and clinical development of ApoC-I...
APOC3 and ANGPTL3 became targets for drug development following the identification of naturally occurring loss of function variants in families with a favorable lipid profile and low cardiovascular ri...
Angiopoietins are crucial growth factors for maintaining a healthy, functional endothelium. Patients with type 2 diabetes (T2D) exhibit significant levels of angiogenic markers, particularly Angiopoie...
After feeding, adipose tissue lipoprotein lipase (LPL) activity should be maximized, therefore the potent LPL-inhibitory activity of angiopoietin-like protein 4 (ANGPTL4) must be blocked by ANGPTL8 th...
Non-alcoholic fatty liver disease (NAFLD) is the most frequent cause of chronic liver disease, with a range of conditions including non-alcoholic fatty liver, non-alcoholic steatohepatitis, cirrhosis,...
Acute myocardial infarction is mainly caused by a lack of blood flood in the coronary artery. Angiopoietin-like protein 2 (ANGPTL2) induces platelet activation and thrombus formation in vitro through ...
RNA-based, antibody-based, and genome editing-based therapies are currently under investigation to determine if the inhibition of angiopoietin-like protein-3 (ANGPTL3) could reduce lipoprotein-lipid l...
RNA sequencing of 246 explanted liver samples and genome-wide genotyping was performed to identify single-nucleotide polymorphisms (SNPs) associated with liver expression of ANGPTL3. Genome-wide summa...
In two-sample MR studies, common genetic variants influencing ANGPTL3 hepatic or blood expression levels of ANGPTL3 had a very strong effect on plasma triglyceride levels, a more modest effect on low-...
PTVs influencing ANGPTL3 protein structure as well as common genetic variants influencing ANGPTL3 hepatic expression and/or blood protein levels exhibit a strong effect on circulating plasma triglycer...
Despite the best pharmacologic tools available, cardiovascular diseases (CVDs) remain a major cause of morbidity and mortality in developed countries. After 2 decades of research, new therapeutic targ...