Maturation of the human striatal dopamine system revealed by PET and quantitative MRI.
Adolescent
Adult
Age Factors
Child
Cognitive Neuroscience
Corpus Striatum
/ diagnostic imaging
Dopamine
/ metabolism
Female
Humans
Kinetics
Magnetic Resonance Imaging
Male
Models, Biological
Neuroimaging
Positron-Emission Tomography
Raclopride
Receptors, Dopamine D2
/ metabolism
Receptors, Dopamine D3
/ metabolism
Tetrabenazine
/ analogs & derivatives
Young Adult
Journal
Nature communications
ISSN: 2041-1723
Titre abrégé: Nat Commun
Pays: England
ID NLM: 101528555
Informations de publication
Date de publication:
12 02 2020
12 02 2020
Historique:
received:
13
07
2019
accepted:
28
01
2020
entrez:
14
2
2020
pubmed:
14
2
2020
medline:
24
4
2020
Statut:
epublish
Résumé
The development of the striatum dopamine (DA) system through human adolescence, a time of increased sensation seeking and vulnerability to the emergence of psychopathology, has been difficult to study due to pediatric restrictions on direct in vivo assessments of DA. Here, we applied neuroimaging in a longitudinal sample of n = 146 participants aged 12-30. R2', an MR measure of tissue iron which co-localizes with DA vesicles and is necessary for DA synthesis, was assessed across the sample. In the 18-30 year-olds (n = 79) we also performed PET using [11C]dihydrotetrabenazine (DTBZ), a measure of presynaptic vesicular DA storage, and [11C]raclopride (RAC), an indicator of D2/D3 receptor availability. We observed decreases in D2/D3 receptor availability with age, while presynaptic vesicular DA storage (as measured by DTBZ), which was significantly associated with R2' (standardized coefficient = 0.29, 95% CI = [0.11, 0.48]), was developmentally stable by age 18. Our results provide new evidence for maturational specialization of the striatal DA system through adolescence.
Identifiants
pubmed: 32051403
doi: 10.1038/s41467-020-14693-3
pii: 10.1038/s41467-020-14693-3
pmc: PMC7015913
doi:
Substances chimiques
Receptors, Dopamine D2
0
Receptors, Dopamine D3
0
dihydrotetrabenazine
3466-75-9
Raclopride
430K3SOZ7G
Dopamine
VTD58H1Z2X
Tetrabenazine
Z9O08YRN8O
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
846Subventions
Organisme : NIMH NIH HHS
ID : R01 MH080243
Pays : United States
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