Effects of Glucagon-like Peptide-1 on the Reproductive Axis in Healthy Men.
follicle stimulating hormone
glucagon-like peptide-1
luteinizing hormone
reproduction
testosterone
Journal
The Journal of clinical endocrinology and metabolism
ISSN: 1945-7197
Titre abrégé: J Clin Endocrinol Metab
Pays: United States
ID NLM: 0375362
Informations de publication
Date de publication:
01 04 2020
01 04 2020
Historique:
received:
06
12
2019
accepted:
10
02
2020
pubmed:
14
2
2020
medline:
5
1
2021
entrez:
14
2
2020
Statut:
ppublish
Résumé
Glucagon-like peptide-1 (GLP-1) potently reduces food intake and augments glucose-stimulated insulin secretion. Recent animal data suggest that GLP-1 may also influence reproduction. As GLP-1 receptor agonists are currently widely used in clinical practice to treat obesity/type 2 diabetes, it is necessary to determine the effects of GLP-1 on the reproductive system in humans. To investigate the effects of GLP-1 administration on the reproductive axis in humans. Single-blind, randomized, placebo-controlled crossover study. Clinical Research Facility, Imperial College Healthcare NHS Trust. Eighteen healthy men (mean age 24.7 ± 0.1years, mean BMI 22.1 ± 0.4kg/m2). Eight-hour intravenous infusion of 0.8 pmol/kg/min GLP-1 or rate-matched vehicle infusion. Number of luteinizing hormone (LH) pulses, LH, follicle-stimulating hormone (FSH), and testosterone levels. The number of LH pulses (number of LH pulses/500 min: vehicle 4.2 ± 0.4, GLP-1 4.5 ± 0.3, P = 0.46), LH area under the curve (AUC) (vehicle 1518 ± 88min.IU/L, GLP-1 1524 ± 101min.IU/L, P = 0.95), follicle-stimulating hormone AUC (vehicle 1210 ± 112 min IU/L, GLP-1 1216 ± 112 min IU/L, P = 0.86), and testosterone AUC (vehicle 10893 ± 615 min nmol/L, GLP-1 11088 ± 792 min nmol/L, P = 0.77) did not significantly differ during vehicle and GLP-1 administration. Glucagon-like peptide-1 significantly reduced food intake (vehicle 15.7 ± 1.3 kcal/kg, GLP-1 13.4 ± 1.3 kcal/kg, P = 0.01). In contrast to the animal literature, our data demonstrate that acute GLP-1 administration does not affect reproductive hormone secretion in healthy men.
Identifiants
pubmed: 32052032
pii: 5735220
doi: 10.1210/clinem/dgaa072
pmc: PMC7082082
pii:
doi:
Substances chimiques
Biomarkers
0
Incretins
0
Glucagon-Like Peptide 1
89750-14-1
Glucagon
9007-92-5
Types de publication
Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Medical Research Council
ID : MR/N020472/1
Pays : United Kingdom
Organisme : Medical Research Council
ID : MR/R000484/1
Pays : United Kingdom
Organisme : Department of Health
ID : CS-2018-18-ST2-002
Pays : United Kingdom
Organisme : Medical Research Council
ID : MR/T006242/1
Pays : United Kingdom
Organisme : Department of Health
ID : RP-2014-05-001
Pays : United Kingdom
Organisme : Wellcome Trust
Pays : United Kingdom
Organisme : Biotechnology and Biological Sciences Research Council
Pays : United Kingdom
Organisme : Medical Research Council
ID : MR/M004171/1
Pays : United Kingdom
Informations de copyright
© Endocrine Society 2020.
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