Thalamus Modulates Consciousness via Layer-Specific Control of Cortex.
Anesthesia, General
Anesthetics, Inhalation
/ pharmacology
Anesthetics, Intravenous
/ pharmacology
Animals
Cerebral Cortex
/ drug effects
Consciousness
/ drug effects
Electric Stimulation
Electroencephalography
Feedback
Frontal Lobe
/ drug effects
Intralaminar Thalamic Nuclei
/ drug effects
Isoflurane
/ pharmacology
Macaca
Neural Pathways
/ drug effects
Parietal Lobe
/ drug effects
Propofol
/ pharmacology
Sleep
/ physiology
Wakefulness
/ physiology
anesthesia
central thalamus
consciousness
deep brain stimulation
feedback
feedforward
frontal cortex
oscillations
parietal cortex
sleep
Journal
Neuron
ISSN: 1097-4199
Titre abrégé: Neuron
Pays: United States
ID NLM: 8809320
Informations de publication
Date de publication:
08 04 2020
08 04 2020
Historique:
received:
19
11
2019
revised:
26
12
2019
accepted:
07
01
2020
pubmed:
14
2
2020
medline:
29
7
2020
entrez:
14
2
2020
Statut:
ppublish
Résumé
Functional MRI and electrophysiology studies suggest that consciousness depends on large-scale thalamocortical and corticocortical interactions. However, it is unclear how neurons in different cortical layers and circuits contribute. We simultaneously recorded from central lateral thalamus (CL) and across layers of the frontoparietal cortex in awake, sleeping, and anesthetized macaques. We found that neurons in thalamus and deep cortical layers are most sensitive to changes in consciousness level, consistent across different anesthetic agents and sleep. Deep-layer activity is sustained by interactions with CL. Consciousness also depends on deep-layer neurons providing feedback to superficial layers (not to deep layers), suggesting that long-range feedback and intracolumnar signaling are important. To show causality, we stimulated CL in anesthetized macaques and effectively restored arousal and wake-like neural processing. This effect was location and frequency specific. Our findings suggest layer-specific thalamocortical correlates of consciousness and inform how targeted deep brain stimulation can alleviate disorders of consciousness.
Identifiants
pubmed: 32053769
pii: S0896-6273(20)30005-2
doi: 10.1016/j.neuron.2020.01.005
pmc: PMC7243351
mid: NIHMS1569336
pii:
doi:
Substances chimiques
Anesthetics, Inhalation
0
Anesthetics, Intravenous
0
Isoflurane
CYS9AKD70P
Propofol
YI7VU623SF
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
66-75.e12Subventions
Organisme : NIH HHS
ID : P51 OD011106
Pays : United States
Organisme : NIMH NIH HHS
ID : R01 MH110311
Pays : United States
Commentaires et corrections
Type : CommentIn
Type : CommentIn
Informations de copyright
Copyright © 2020 Elsevier Inc. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of Interests A.R. is a consultant for and receives funding from Medtronic. The other authors declare no competing interests.
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