CtpB is a plasma membrane copper (I) transporting P-type ATPase of Mycobacterium tuberculosis.

Copper transport CtpB Mycobacterium tuberculosis P-type ATPase Plasma membrane

Journal

Biological research
ISSN: 0717-6287
Titre abrégé: Biol Res
Pays: England
ID NLM: 9308271

Informations de publication

Date de publication:
13 Feb 2020
Historique:
received: 08 06 2019
accepted: 30 01 2020
entrez: 15 2 2020
pubmed: 15 2 2020
medline: 16 4 2020
Statut: epublish

Résumé

The intracellular concentration of heavy-metal cations, such as copper, nickel, and zinc is pivotal for the mycobacterial response to the hostile environment inside macrophages. To date, copper transport mediated by P-type ATPases across the mycobacterial plasma membrane has not been sufficiently explored. In this work, the ATPase activity of the putative Mycobacterium tuberculosis P The overall results suggest that M. tuberculosis CtpB is associated with Cu

Sections du résumé

BACKGROUND BACKGROUND
The intracellular concentration of heavy-metal cations, such as copper, nickel, and zinc is pivotal for the mycobacterial response to the hostile environment inside macrophages. To date, copper transport mediated by P-type ATPases across the mycobacterial plasma membrane has not been sufficiently explored.
RESULTS RESULTS
In this work, the ATPase activity of the putative Mycobacterium tuberculosis P
CONCLUSIONS CONCLUSIONS
The overall results suggest that M. tuberculosis CtpB is associated with Cu

Identifiants

pubmed: 32054527
doi: 10.1186/s40659-020-00274-7
pii: 10.1186/s40659-020-00274-7
pmc: PMC7017476
doi:

Substances chimiques

Copper-Transporting ATPases EC 7.2.2.8

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

6

Subventions

Organisme : Colciencias
ID : FP44842-108-2016

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Auteurs

Andrés León-Torres (A)

Chemistry Department, Faculty of Sciences, Universidad Nacional de Colombia, Carrera 30 N° 45-03, Ciudad Universitaria, Bogotá, Colombia.

Epifania Arango (E)

Chemistry Department, Faculty of Sciences, Universidad Nacional de Colombia, Carrera 30 N° 45-03, Ciudad Universitaria, Bogotá, Colombia.

Eliana Castillo (E)

Chemistry Department, Faculty of Sciences, Universidad Nacional de Colombia, Carrera 30 N° 45-03, Ciudad Universitaria, Bogotá, Colombia.

Carlos Y Soto (CY)

Chemistry Department, Faculty of Sciences, Universidad Nacional de Colombia, Carrera 30 N° 45-03, Ciudad Universitaria, Bogotá, Colombia. cysotoo@unal.edu.co.

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Classifications MeSH