Enhancing neuronal chloride extrusion rescues α2/α3 GABA
Analgesia
/ methods
Analgesics
/ metabolism
Animals
Brain-Derived Neurotrophic Factor
/ metabolism
Chlorides
/ metabolism
Disease Models, Animal
Fluorobenzenes
/ metabolism
GABA-A Receptor Agonists
/ pharmacology
Ion Transport
/ drug effects
Ligands
Male
Neuralgia
/ drug therapy
Neurons
/ drug effects
Peripheral Nerve Injuries
/ drug therapy
Rats
Rats, Sprague-Dawley
Receptor, trkB
/ metabolism
Receptors, GABA-A
/ physiology
Symporters
/ metabolism
Synapses
/ drug effects
Triazoles
/ metabolism
K Cl- Cotransporters
Journal
Nature communications
ISSN: 2041-1723
Titre abrégé: Nat Commun
Pays: England
ID NLM: 101528555
Informations de publication
Date de publication:
13 02 2020
13 02 2020
Historique:
received:
09
05
2018
accepted:
16
12
2019
entrez:
15
2
2020
pubmed:
15
2
2020
medline:
28
4
2020
Statut:
epublish
Résumé
Spinal disinhibition has been hypothesized to underlie pain hypersensitivity in neuropathic pain. Apparently contradictory mechanisms have been reported, raising questions on the best target to produce analgesia. Here, we show that nerve injury is associated with a reduction in the number of inhibitory synapses in the spinal dorsal horn. Paradoxically, this is accompanied by a BDNF-TrkB-mediated upregulation of synaptic GABA
Identifiants
pubmed: 32054836
doi: 10.1038/s41467-019-14154-6
pii: 10.1038/s41467-019-14154-6
pmc: PMC7018745
doi:
Substances chimiques
Analgesics
0
Bdnf protein, rat
0
Brain-Derived Neurotrophic Factor
0
Chlorides
0
Fluorobenzenes
0
GABA-A Receptor Agonists
0
Ligands
0
Receptors, GABA-A
0
Symporters
0
Triazoles
0
L 838,417
8CZO0970G3
Ntrk2 protein, rat
EC 2.7.10.1
Receptor, trkB
EC 2.7.10.1
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
869Références
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