An efficient and targeted synthetic approach towards new highly substituted 6-amino-pyrazolo[1,5-a]pyrimidines with α-glucosidase inhibitory activity.
Journal
Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288
Informations de publication
Date de publication:
13 02 2020
13 02 2020
Historique:
received:
05
08
2019
accepted:
16
12
2019
entrez:
15
2
2020
pubmed:
15
2
2020
medline:
20
11
2020
Statut:
epublish
Résumé
In an attempt to find novel α-glucosidase inhibitors, an efficient, straightforward reaction to synthesize a library of fully substituted 6-amino-pyrazolo[1,5-a]pyrimidines 3 has been investigated. Heating a mixture of α-azidochalcones 1 and 3-aminopyrazoles 2 under the mild condition afforded desired compounds with a large substrate scope in good to excellent yields. All obtained products were evaluated as α-glucosidase inhibitors and exhibited excellent potency with IC
Identifiants
pubmed: 32054916
doi: 10.1038/s41598-020-59079-z
pii: 10.1038/s41598-020-59079-z
pmc: PMC7018746
doi:
Substances chimiques
3-aminopyrazole
0
Glycoside Hydrolase Inhibitors
0
Pyrazoles
0
Pyridines
0
alpha-Glucosidases
EC 3.2.1.20
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
2595Références
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