The relationship between all-cause mortality and depression in different gender and age groups of the Spanish population.
Age
All-cause
Depression
Gender
Mortality
Journal
Journal of affective disorders
ISSN: 1573-2517
Titre abrégé: J Affect Disord
Pays: Netherlands
ID NLM: 7906073
Informations de publication
Date de publication:
01 04 2020
01 04 2020
Historique:
received:
31
10
2019
revised:
10
12
2019
accepted:
28
01
2020
pubmed:
15
2
2020
medline:
16
2
2021
entrez:
15
2
2020
Statut:
ppublish
Résumé
Literature has shown that the effect of depression on all-cause mortality is stronger in men. However, it is less clear whether depression affects older and younger people equally. The present study is aimed to analyze whether depression is associated to all-cause mortality in different age and gender groups. We analyzed a nationally representative sample of the Spanish adult population that was followed-up on for a period of 6 years (n = 4583). Unadjusted and adjusted cox proportional hazard regression models were conducted to test whether baseline depression was associated to all-cause mortality in the total sample and in the different gender and age specific groups, separately. Unadjusted analyses revealed that depression was associated with higher likelihood of having a shorter survival and dying, in the total sample and in both groups of men (18-64 and 65+ years). However, adjusted analyses stratified by age groups and gender revealed that depression was only a significant factor for all-cause mortality in 18-64 aged men (HR: 6.11; 95%CI= 2.16,17.23). Cause-specific mortality was not examined. Young adults and middle-aged participants were not analyzed separately. The depression and all-cause mortality relationship was only found among young and middle-aged men. Further studies should consider whether the significant association between depression and all-cause mortality in young and middle-aged men is due to a behavior of seeking help less, the way depression is shaped in adult men, or to other clinical or health-system related factors.
Sections du résumé
BACKGROUND
Literature has shown that the effect of depression on all-cause mortality is stronger in men. However, it is less clear whether depression affects older and younger people equally. The present study is aimed to analyze whether depression is associated to all-cause mortality in different age and gender groups.
METHODS
We analyzed a nationally representative sample of the Spanish adult population that was followed-up on for a period of 6 years (n = 4583). Unadjusted and adjusted cox proportional hazard regression models were conducted to test whether baseline depression was associated to all-cause mortality in the total sample and in the different gender and age specific groups, separately.
RESULTS
Unadjusted analyses revealed that depression was associated with higher likelihood of having a shorter survival and dying, in the total sample and in both groups of men (18-64 and 65+ years). However, adjusted analyses stratified by age groups and gender revealed that depression was only a significant factor for all-cause mortality in 18-64 aged men (HR: 6.11; 95%CI= 2.16,17.23).
LIMITATIONS
Cause-specific mortality was not examined. Young adults and middle-aged participants were not analyzed separately.
CONCLUSIONS
The depression and all-cause mortality relationship was only found among young and middle-aged men. Further studies should consider whether the significant association between depression and all-cause mortality in young and middle-aged men is due to a behavior of seeking help less, the way depression is shaped in adult men, or to other clinical or health-system related factors.
Identifiants
pubmed: 32056909
pii: S0165-0327(19)33044-7
doi: 10.1016/j.jad.2020.01.162
pii:
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
424-428Informations de copyright
Copyright © 2020. Published by Elsevier B.V.
Déclaration de conflit d'intérêts
Declaration of Competing Interest None