Heroin-induced respiratory depression and the influence of dose variation: within-subject between-session changes following dose reduction.
Depression
HAT
heroin
opioid
overdose
respiratory
Journal
Addiction (Abingdon, England)
ISSN: 1360-0443
Titre abrégé: Addiction
Pays: England
ID NLM: 9304118
Informations de publication
Date de publication:
10 2020
10 2020
Historique:
received:
18
12
2019
revised:
23
12
2019
accepted:
07
02
2020
pubmed:
15
2
2020
medline:
20
4
2021
entrez:
15
2
2020
Statut:
ppublish
Résumé
Globally, more than 100 000 people die annually from opioid overdose. Opportunities to study physiological events in at-risk individuals are limited. This study examined variation of opioid dose and impact on respiratory depression in a chronic injecting heroin user at separate time-points during his long-term diamorphine maintenance treatment. A single-subject study over 5 years during which participant underwent experimental studies on diamorphine-induced respiratory depression, at changing maintenance doses. A clinical research facility. Participant Male subject on long-term injectable diamorphine (pharmaceutical heroin) maintenance treatment for heroin addiction. Physiological measures of oxygen saturation (SpO (1) After diamorphine injection, respiratory regulation became abnormal, with prolonged apnoea exceeding 20 sec (maximum 56 sec), elevated ETCO With marked inter-session variability, these findings corroborate observations of inconsistent relationships between opioid dose and overdose risk.
Sections du résumé
BACKGROUND AND AIMS
Globally, more than 100 000 people die annually from opioid overdose. Opportunities to study physiological events in at-risk individuals are limited. This study examined variation of opioid dose and impact on respiratory depression in a chronic injecting heroin user at separate time-points during his long-term diamorphine maintenance treatment.
DESIGN
A single-subject study over 5 years during which participant underwent experimental studies on diamorphine-induced respiratory depression, at changing maintenance doses.
SETTING
A clinical research facility. Participant Male subject on long-term injectable diamorphine (pharmaceutical heroin) maintenance treatment for heroin addiction.
MEASUREMENTS
Physiological measures of oxygen saturation (SpO
FINDINGS
(1) After diamorphine injection, respiratory regulation became abnormal, with prolonged apnoea exceeding 20 sec (maximum 56 sec), elevated ETCO
CONCLUSIONS
With marked inter-session variability, these findings corroborate observations of inconsistent relationships between opioid dose and overdose risk.
Substances chimiques
Analgesics, Opioid
0
Heroin
70D95007SX
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
1954-1959Informations de copyright
© 2020 Society for the Study of Addiction.
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