Do Parkinson disease subject and caregiver-reported Epworth sleepiness scale reponses correlate?
Aged
Aged, 80 and over
Caregivers
Case-Control Studies
Cognitive Dysfunction
/ complications
Dementia
/ complications
Disorders of Excessive Somnolence
/ complications
Female
Humans
Male
Parkinson Disease
/ complications
Reproducibility of Results
Severity of Illness Index
Sleepiness
Surveys and Questionnaires
Cognitive impairment
Dementia
Epworth sleepiness scale
Excessive daytime sleepiness
Mild cognitive impairment
Parkinson disease
Journal
Clinical neurology and neurosurgery
ISSN: 1872-6968
Titre abrégé: Clin Neurol Neurosurg
Pays: Netherlands
ID NLM: 7502039
Informations de publication
Date de publication:
05 2020
05 2020
Historique:
received:
12
05
2019
revised:
01
02
2020
accepted:
06
02
2020
pubmed:
15
2
2020
medline:
23
6
2021
entrez:
15
2
2020
Statut:
ppublish
Résumé
Subjective excessive daytime sleepiness, commonly measured with the Epworth Sleepiness Scale (ESS), is associated with cognitive impairment in Parkinson disease (PD). Significant correlation between subject and informant responses has been reported in neurologically healthy individuals. We sought to assess this correlation in patients with PD. 854 individuals in the Arizona Study of Aging and Neurodegenerative Disorders (AZSAND) had subject as well as informant-completed ESS completed within one year of a movement disorder exam and cognitive assessment. Correlations were evaluated using Spearman's rank correlation coefficients. Overall, 397/854(46.5 %) were female with mean age of 77.5 (SD 8.3). 572 (67 %) were cognitively normal (CogNL), 135 (15.8 %) had mild cognitive impairment (MCI) and 147 (17.2 %) dementia. Spearman R correlations (all with p < 0.001) between subject and informant ESS responses were 0.73 overall, 0.67 for the CogNL group, 0.79 for the MCI group, 0.79 for those with dementia. Of 175 with clinically probable PD, 115 (65.7 %) were CogNL, 38 had MCI, and 22 (12.6 %) dementia. For subjects with PD correlations (all with p < 0.001) were 0.65 for PD-CogNL, 0.83 for PD-MCI, and 0.70 for those with PD-dementia. These significant correlations between subject and informant-completed ESS can be useful in guiding clinical trials designed to assess efficacy of potential treatments for excessive daytime sleepiness for the general population and for patients with PD, even those having cognitive impairment.
Identifiants
pubmed: 32058206
pii: S0303-8467(20)30071-8
doi: 10.1016/j.clineuro.2020.105728
pmc: PMC7183413
mid: NIHMS1561683
pii:
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
105728Subventions
Organisme : NIA NIH HHS
ID : P30 AG019610
Pays : United States
Organisme : NINDS NIH HHS
ID : U24 NS072026
Pays : United States
Informations de copyright
Copyright © 2020 Elsevier B.V. All rights reserved.
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