Differential Signaling Profiles of MC4R Mutations with Three Different Ligands.
Amino Acid Sequence
Cyclic AMP
/ metabolism
Gene Expression Regulation
HEK293 Cells
Humans
Leptin
/ metabolism
Ligands
Melanocortins
/ metabolism
Models, Theoretical
Mutation
Obesity
/ genetics
Phosphorylation
Polymorphism, Single Nucleotide
Receptor, Melanocortin, Type 4
/ genetics
Receptors, G-Protein-Coupled
/ metabolism
Signal Transduction
/ physiology
alpha-MSH
/ metabolism
G protein coupled receptor (GPCR)
Melanocortin 4 receptor (MC4R)
Melanocyte stimulating hormones MSH
biased signaling
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
12 Feb 2020
12 Feb 2020
Historique:
received:
19
12
2019
revised:
06
02
2020
accepted:
06
02
2020
entrez:
16
2
2020
pubmed:
16
2
2020
medline:
15
12
2020
Statut:
epublish
Résumé
The melanocortin 4 receptor (MC4R) is a key player in hypothalamic weight regulation and energy expenditure as part of the leptin-melanocortin pathway. Mutations in this G protein coupled receptor (GPCR) are the most common cause for monogenetic obesity, which appears to be mediated by changes in the anorectic action of MC4R via G
Identifiants
pubmed: 32059383
pii: ijms21041224
doi: 10.3390/ijms21041224
pmc: PMC7072973
pii:
doi:
Substances chimiques
Leptin
0
Ligands
0
MC4R protein, human
0
Melanocortins
0
Receptor, Melanocortin, Type 4
0
Receptors, G-Protein-Coupled
0
alpha-MSH
581-05-5
Cyclic AMP
E0399OZS9N
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Références
Obesity (Silver Spring). 2008 Feb;16(2):369-76
pubmed: 18239646
J Clin Invest. 2016 Jan;126(1):40-9
pubmed: 26595811
Front Pharmacol. 2019 Sep 13;10:1027
pubmed: 31572197
Handb Exp Pharmacol. 2012;(209):47-75
pubmed: 22249810
J Surg Res. 2006 May 15;132(2):201-7
pubmed: 16580690
Trends Mol Med. 2019 Feb;25(2):136-148
pubmed: 30642682
Nat Genet. 1998 Oct;20(2):111-2
pubmed: 9771698
Nat Med. 2018 May;24(5):551-555
pubmed: 29736023
Obes Res. 2004 Jul;12(7):1060-6
pubmed: 15292469
J Bone Miner Res. 2000 Sep;15(9):1697-706
pubmed: 10976990
Obesity (Silver Spring). 2010 Mar;18(3):573-9
pubmed: 19696756
Proc Natl Acad Sci U S A. 1980 Oct;77(10):5754-8
pubmed: 6777774
Am J Hum Genet. 2004 Mar;74(3):572-81
pubmed: 14973783
Cell. 2019 Apr 18;177(3):597-607.e9
pubmed: 31002796
Int J Obes (Lond). 2007 Sep;31(9):1437-41
pubmed: 17356525
BMC Med Genet. 2009 Mar 12;10:25
pubmed: 19284607
J Clin Endocrinol Metab. 2004 Feb;89(2):940-5
pubmed: 14764818
Hum Genet. 2009 Jan;124(6):633-47
pubmed: 19011902
Cell Metab. 2006 Feb;3(2):141-6
pubmed: 16459315
Peptides. 2006 Nov;27(11):2846-57
pubmed: 16806584
Nat Neurosci. 2005 May;8(5):571-8
pubmed: 15856065
Endocrinology. 2005 Dec;146(12):5257-66
pubmed: 16166226
Front Endocrinol (Lausanne). 2019 Jul 31;10:515
pubmed: 31417496
Br J Pharmacol. 2016 Apr;173(8):1393-403
pubmed: 26791140
Mol Endocrinol. 2013 Nov;27(11):1934-45
pubmed: 24085819
Am J Hum Genet. 2007 Apr;80(4):779-91
pubmed: 17357083
Regul Pept. 2001 May 5;99(1):1-7
pubmed: 11257308
Hum Mol Genet. 2003 Jan 15;12(2):145-53
pubmed: 12499395
Nat Genet. 1998 Oct;20(2):113-4
pubmed: 9771699
J Biochem. 2004 Apr;135(4):541-6
pubmed: 15115780
J Mol Endocrinol. 2013 Jun 29;51(1):109-18
pubmed: 23674133
Horm Res Paediatr. 2012;78(4):237-46
pubmed: 23146882
J Clin Endocrinol Metab. 2003 Sep;88(9):4258-67
pubmed: 12970296
Hum Mol Genet. 2007 Aug 1;16(15):1837-44
pubmed: 17519222
Diabetes. 2012 Jan;61(1):250-7
pubmed: 22106157
Peptides. 2005 Oct;26(10):1842-7
pubmed: 15982783
Regul Pept. 2004 Aug 15;120(1-3):113-8
pubmed: 15177928
Nat Rev Drug Discov. 2018 Apr;17(4):243-260
pubmed: 29302067
Mol Endocrinol. 1999 Jan;13(1):148-55
pubmed: 9892020
Biochemistry. 2006 Jun 13;45(23):7277-88
pubmed: 16752916
J Med Genet. 2005 Apr;42(4):e21
pubmed: 15805150
J Biol Chem. 2009 Sep 25;284(39):26411-20
pubmed: 19648111
Cell. 2019 Jun 13;177(7):1933-1947.e25
pubmed: 31160049
Mol Endocrinol. 2001 Jan;15(1):164-71
pubmed: 11145747
J Clin Endocrinol Metab. 2006 May;91(5):1761-9
pubmed: 16492696
J Clin Invest. 2000 Jul;106(2):253-62
pubmed: 10903341
Brain Res. 2003 Oct 3;986(1-2):1-11
pubmed: 12965224
PLoS One. 2007 Aug 01;2(7):e668
pubmed: 17668051
Science. 2013 Jul 19;341(6143):278-81
pubmed: 23869017
Obesity (Silver Spring). 2016 Sep;24(9):1976-82
pubmed: 27474872
Mol Pharmacol. 2017 Oct;92(4):414-424
pubmed: 28679508
Nat Commun. 2019 Oct 25;10(1):4897
pubmed: 31653860
J Biol Chem. 1993 Jul 15;268(20):15174-9
pubmed: 8392067
J Neurochem. 2001 Sep;78(5):981-90
pubmed: 11553672
J Neuroendocrinol. 2019 Oct;31(10):e12795
pubmed: 31529534
J Endocrinol. 2010 Nov;207(2):177-83
pubmed: 20696697
Diabetes. 2003 Dec;52(12):2984-8
pubmed: 14633860
J Cell Mol Med. 2009 Sep;13(9B):3268-82
pubmed: 19298524
Mol Biol Rep. 2014 Mar;41(3):1491-500
pubmed: 24385306
Eur J Pharmacol. 1995 Feb 15;288(3):311-7
pubmed: 7774675
J Biomol Screen. 2009 Mar;14(3):246-55
pubmed: 19211780
Diabetes. 1999 Mar;48(3):635-9
pubmed: 10078568
J Biol Chem. 1999 Dec 10;274(50):35816-22
pubmed: 10585465
Biochim Biophys Acta. 2013 Dec;1832(12):1939-48
pubmed: 23791567
J Pediatr. 2007 Jun;150(6):618-22, 622.e1-5
pubmed: 17517246
Front Pharmacol. 2018 Mar 12;9:222
pubmed: 29593543
Peptides. 2006 Feb;27(2):372-9
pubmed: 16289450
Int J Biol Sci. 2014 Oct 09;10(10):1128-37
pubmed: 25332687
Nat Commun. 2018 Jan 23;9(1):341
pubmed: 29362459