UV-Photofunctionalization of Titanium Promotes Mechanical Anchorage in A Rat Osteoporosis Model.
Alkaline Phosphatase
Animals
Bone Density
/ drug effects
Bone Regeneration
/ drug effects
Bone and Bones
Calcification, Physiologic
/ drug effects
Cell Proliferation
Dental Implants
Female
Gene Expression
Hydrophobic and Hydrophilic Interactions
Osseointegration
/ drug effects
Osteoblasts
/ drug effects
Osteogenesis
/ drug effects
Osteoporosis
Ovariectomy
Rats
Rats, Sprague-Dawley
Surface Properties
Titanium
/ pharmacology
Ultraviolet Rays
UV light treatment
bone integration
bone regeneration
dental implants
mechanical anchorage
orthopedic implants
osteoblast
osteoporosis
ovariectomy
titanium
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
12 Feb 2020
12 Feb 2020
Historique:
received:
30
12
2019
revised:
06
02
2020
accepted:
11
02
2020
entrez:
16
2
2020
pubmed:
16
2
2020
medline:
15
12
2020
Statut:
epublish
Résumé
Effects of UV-photofunctionalization on bone-to-titanium integration under challenging systemic conditions remain unclear. We examined the behavior and response of osteoblasts from sham-operated and ovariectomized (OVX) rats on titanium surfaces with or without UV light pre-treatment and the strength of bone-implant integration. Osteoblasts from OVX rats showed significantly lower alkaline phosphatase, osteogenic gene expression, and mineralization activities than those from sham rats. Bone density variables in the spine were consistently lower in OVX rats. UV-treated titanium was superhydrophilic and the contact angle of ddH
Identifiants
pubmed: 32059603
pii: ijms21041235
doi: 10.3390/ijms21041235
pmc: PMC7072956
pii:
doi:
Substances chimiques
Dental Implants
0
Titanium
D1JT611TNE
Alkaline Phosphatase
EC 3.1.3.1
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Déclaration de conflit d'intérêts
The authors declare no conflicts of interest.
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