A comprehensive and comparative phenotypic analysis of the collaborative founder strains identifies new and known phenotypes.
Journal
Mammalian genome : official journal of the International Mammalian Genome Society
ISSN: 1432-1777
Titre abrégé: Mamm Genome
Pays: United States
ID NLM: 9100916
Informations de publication
Date de publication:
02 2020
02 2020
Historique:
received:
23
10
2019
accepted:
31
01
2020
pubmed:
16
2
2020
medline:
15
12
2020
entrez:
16
2
2020
Statut:
ppublish
Résumé
The collaborative cross (CC) is a large panel of mouse-inbred lines derived from eight founder strains (NOD/ShiLtJ, NZO/HILtJ, A/J, C57BL/6J, 129S1/SvImJ, CAST/EiJ, PWK/PhJ, and WSB/EiJ). Here, we performed a comprehensive and comparative phenotyping screening to identify phenotypic differences and similarities between the eight founder strains. In total, more than 300 parameters including allergy, behavior, cardiovascular, clinical blood chemistry, dysmorphology, bone and cartilage, energy metabolism, eye and vision, immunology, lung function, neurology, nociception, and pathology were analyzed; in most traits from sixteen females and sixteen males. We identified over 270 parameters that were significantly different between strains. This study highlights the value of the founder and CC strains for phenotype-genotype associations of many genetic traits that are highly relevant to human diseases. All data described here are publicly available from the mouse phenome database for analyses and downloads.
Identifiants
pubmed: 32060626
doi: 10.1007/s00335-020-09827-3
pii: 10.1007/s00335-020-09827-3
pmc: PMC7060152
doi:
Types de publication
Comparative Study
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
30-48Subventions
Organisme : NIDA NIH HHS
ID : R01 DA028420
Pays : United States
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