questionsmedicales.fr
Eucaryotes
Animaux
Chordés
Vertébrés
Mammifères
Eutheria
Rodentia
Muridae
Murinae
Souris
Lignées consanguines de souris
Souris du Collaborative Cross
Souris du Collaborative Cross : Questions médicales fréquentes
Diagnostic
5
Séquençage de l'ADN
Polymorphisme
Diversité génétique
Phénotype
Comportement
Tests comportementaux
Symptômes
5
Symptômes
Troubles métaboliques
Maladies auto-immunes
Inflammation
Prévention
5
Prévention
Régime alimentaire
Soins préventifs
Vaccination
Stress environnemental
Habitat
Bien-être animal
Protocoles
Toxicité
Tests de sécurité
Traitements
5
Efficacité
Analyses biologiques
Réponse au traitement
Modèles animaux
Thérapies ciblées
Modèles animaux
Administration de médicaments
Voies d'administration
Complications
5
Gestion des complications
Surveillance
Maladies secondaires
Stress
Prévention des complications
Protocoles
Facteurs de risque
5
Facteurs de risque
Génétique
Alimentation
Troubles métaboliques
Conditions de logement
Bien-être animal
Prédispositions génétiques
Maladies
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"name": "Y a-t-il des signes de maladies auto-immunes ?",
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"name": "Comment prévenir les maladies chez ces souris ?",
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"acceptedAnswer": {
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"text": "Des régimes alimentaires contrôlés et des environnements enrichis peuvent aider à prévenir les maladies."
}
},
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"@type": "Question",
"name": "Les souris bénéficient-elles de soins préventifs ?",
"position": 12,
"acceptedAnswer": {
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"text": "Oui, des soins préventifs comme les vaccinations peuvent être appliqués dans certaines études."
}
},
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"name": "Comment réduire le stress environnemental ?",
"position": 13,
"acceptedAnswer": {
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"text": "En fournissant un habitat enrichi et en minimisant les manipulations stressantes."
}
},
{
"@type": "Question",
"name": "Y a-t-il des protocoles de bien-être ?",
"position": 14,
"acceptedAnswer": {
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"text": "Oui, des protocoles stricts de bien-être animal sont suivis pour assurer leur santé."
}
},
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"@type": "Question",
"name": "Les souris sont-elles soumises à des tests de toxicité ?",
"position": 15,
"acceptedAnswer": {
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}
},
{
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"name": "Quels traitements sont testés sur ces souris ?",
"position": 16,
"acceptedAnswer": {
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"text": "Des médicaments, thérapies géniques et interventions comportementales sont souvent testés."
}
},
{
"@type": "Question",
"name": "Comment évaluer l'efficacité d'un traitement ?",
"position": 17,
"acceptedAnswer": {
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}
},
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"@type": "Question",
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"position": 18,
"acceptedAnswer": {
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"text": "Elles peuvent répondre de manière variable, ce qui aide à prédire les réponses humaines."
}
},
{
"@type": "Question",
"name": "Peut-on utiliser des thérapies ciblées ?",
"position": 19,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, les thérapies ciblées sont testées pour leur efficacité sur des modèles spécifiques."
}
},
{
"@type": "Question",
"name": "Comment les traitements sont-ils administrés ?",
"position": 20,
"acceptedAnswer": {
"@type": "Answer",
"text": "Les traitements peuvent être administrés par voie orale, injection ou inhalation selon l'étude."
}
},
{
"@type": "Question",
"name": "Quelles complications peuvent survenir lors des études ?",
"position": 21,
"acceptedAnswer": {
"@type": "Answer",
"text": "Des complications incluent des infections, des réactions aux traitements ou des erreurs de manipulation."
}
},
{
"@type": "Question",
"name": "Comment gérer les complications ?",
"position": 22,
"acceptedAnswer": {
"@type": "Answer",
"text": "Une surveillance étroite et des interventions rapides sont essentielles pour gérer les complications."
}
},
{
"@type": "Question",
"name": "Les souris peuvent-elles développer des maladies secondaires ?",
"position": 23,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, des maladies secondaires peuvent survenir en raison de stress ou de traitements."
}
},
{
"@type": "Question",
"name": "Y a-t-il des risques de mortalité ?",
"position": 24,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, des risques de mortalité existent, surtout en cas de maladies graves ou de traitements toxiques."
}
},
{
"@type": "Question",
"name": "Comment prévenir les complications lors des études ?",
"position": 25,
"acceptedAnswer": {
"@type": "Answer",
"text": "En suivant des protocoles rigoureux et en assurant un environnement stable et sain."
}
},
{
"@type": "Question",
"name": "Quels facteurs de risque influencent la santé des souris ?",
"position": 26,
"acceptedAnswer": {
"@type": "Answer",
"text": "Des facteurs comme la génétique, l'alimentation et l'environnement peuvent influencer leur santé."
}
},
{
"@type": "Question",
"name": "L'âge des souris affecte-t-il les résultats ?",
"position": 27,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, l'âge peut influencer la susceptibilité aux maladies et la réponse aux traitements."
}
},
{
"@type": "Question",
"name": "Comment l'alimentation impacte-t-elle leur santé ?",
"position": 28,
"acceptedAnswer": {
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}
},
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"@type": "Question",
"name": "Les conditions de logement influencent-elles leur bien-être ?",
"position": 29,
"acceptedAnswer": {
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"text": "Oui, des conditions de logement inappropriées peuvent causer du stress et des maladies."
}
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"@type": "Question",
"name": "Y a-t-il des prédispositions génétiques ?",
"position": 30,
"acceptedAnswer": {
"@type": "Answer",
"text": "Certaines lignées de souris présentent des prédispositions génétiques à des maladies spécifiques."
}
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}
Expert en Médecine, Optimisation des Parcours de Soins et Révision Médicale
Validation scientifique effectuée le 29/03/2026
Contenu vérifié selon les dernières recommandations médicales
8 publications dans cette catégorie
Affiliations :
Department of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.
Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.
8 publications dans cette catégorie
6 publications dans cette catégorie
Affiliations :
Department of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.
5 publications dans cette catégorie
Affiliations :
Biological Systems and Engineering Division, Lawrence Berkeley National Laboratory, Berkeley, CA, 94720, USA.
Publications dans "Souris du Collaborative Cross" :
5 publications dans cette catégorie
Affiliations :
Biological Systems and Engineering Division, Lawrence Berkeley National Laboratory, Berkeley, CA, 94720, USA.
Publications dans "Souris du Collaborative Cross" :
4 publications dans cette catégorie
Affiliations :
Department of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.
Publications dans "Souris du Collaborative Cross" :
4 publications dans cette catégorie
Affiliations :
Department of Microbiology & Immunology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.
Department of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.
Publications dans "Souris du Collaborative Cross" :
4 publications dans cette catégorie
Affiliations :
The Jackson Laboratory, Bar Harbor, Maine 04609 Elissa.Chesler@jax.org.
Genome Science and Technology Program, University of Tennessee, Tennessee 37830.
Biosciences Division, Oak Ridge National Laboratory, Tennessee 37830.
Publications dans "Souris du Collaborative Cross" :
4 publications dans cette catégorie
Affiliations :
Department of Internal Hematology, Zhongnan Hospital of Wuhan University, Wuhan, 430071, Hubei, China.
Publications dans "Souris du Collaborative Cross" :
4 publications dans cette catégorie
Affiliations :
Department of Gastroenterology, Nanjing Drum Tower Hospital, Affiliated Hospital of Nanjing University Medical School, Nanjing, 210008, Jiangsu, China.
Publications dans "Souris du Collaborative Cross" :
4 publications dans cette catégorie
Affiliations :
Biological Systems and Engineering Division, Lawrence Berkeley National Laboratory, Berkeley, CA, 94720, USA. HChang@lbl.gov.
Publications dans "Souris du Collaborative Cross" :
4 publications dans cette catégorie
Affiliations :
Department of Clinical Microbiology and Immunology, Sackler Faculty of Medicine, Tel-Aviv University, Tel-Aviv, Israel.
Publications dans "Souris du Collaborative Cross" :
3 publications dans cette catégorie
Affiliations :
Department of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.
Publications dans "Souris du Collaborative Cross" :
3 publications dans cette catégorie
Affiliations :
Department of Genetics, University of North Carolina, Chapel Hill, NC, USA.
Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, NC, USA.
Publications dans "Souris du Collaborative Cross" :
3 publications dans cette catégorie
Affiliations :
Department of Genetics, University of North Carolina, Chapel Hill, NC, USA.
Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, NC, USA.
Publications dans "Souris du Collaborative Cross" :
3 publications dans cette catégorie
Affiliations :
Genetics Institute, University College London, London, United Kingdom.
Publications dans "Souris du Collaborative Cross" :
3 publications dans cette catégorie
Affiliations :
Department of Genetics, School of Medicine, University of North Carolina, Chapel Hill, North Carolina, USA.
Publications dans "Souris du Collaborative Cross" :
3 publications dans cette catégorie
Affiliations :
School of Public Health, Nanjing Medical University, Nanjing, 211166, Jiangsu, China.
Publications dans "Souris du Collaborative Cross" :
3 publications dans cette catégorie
Affiliations :
Department of Nutrition, Texas A&M University, College Station, TX, 77843, USA; Department of Molecular and Cellular Medicine and Department of Biochemistry & Biophysics, Texas A&M University, College Station, TX, 77843, USA.
Publications dans "Souris du Collaborative Cross" :
2 publications dans cette catégorie
Affiliations :
Interdisciplinary Program in Genetics and Genomics, Texas A&M University, College Station, Texas, United States of America.
Department of Microbial Pathogenesis and Immunology, Texas A&M University, College Station, Texas, United States of America.
Publications dans "Souris du Collaborative Cross" :
Staphylococcus aureus (S. aureus) colonizes humans asymptomatically but can also cause opportunistic infections, ranging from mild skin infections to severe life-threatening conditions. Resistance and...
Early dietary introduction of peanut has shown efficacy in clinical trials and driven pediatric recommendations for early introduction of peanut to children with heightened allergy risk worldwide. Unf...
We aimed to determine whether environmental adjuvant-driven airway sensitization and oral tolerance to peanut could be induced in various genetically diverse mouse strains....
C57BL/6J and 12 Collaborative Cross (CC) mouse strains were fed regular chow or...
Without oral peanut feeding, most CC strains (11/12) and C57BL/6J induced peanut-specific IgE and IgG1 following airway exposure to peanut and LPS. With oral peanut feeding none of the CC strains nor ...
Allergic sensitization and oral tolerance to peanut can be achieved across a range of genetically diverse mice. Notably, the same strains that became allergic via airway sensitization were tolerized b...
The response to infection is generally heterogeneous and diverse, with some individuals remaining asymptomatic while others present with severe disease or a diverse range of symptoms. Here, we address...
Deeper insights into ERBB2-driven cancers are essential to develop new treatment approaches for ERBB2+ breast cancers (BCs). We employed the Collaborative Cross (CC) mouse model to unearth genetic fac...
732 F1 hybrid female mice between FVB/N MMTV-Erbb2 and 30 CC strains were monitored for mammary tumour phenotypes. GWAS pinpointed SNPs that influence various tumour phenotypes. Multivariate analyses ...
Distinct variances in tumour onset, multiplicity, and metastatic patterns were observed in F1-hybrid female mice between FVB/N MMTV-Erbb2 and 30 CC strains. Besides lung metastasis, liver and kidney m...
Our investigation has unveiled many new genes predisposing individuals to ERBB2-driven cancer. Translational findings indicate that hTSGS holds promise as a biomarker for refining treatment strategies...
The U.S. Department of Defense (DoD) Breast Cancer Research Program (BCRP) (BC190820), United States; MCIN/AEI/10.13039/501100011039 (PID2020-118527RB-I00, PDC2021-121735-I00), the "European Union Nex...
Staphylococcus aureus (S. aureus) is an opportunistic pathogen causing diseases ranging from mild skin infections to life threatening conditions, including endocarditis, pneumonia, and sepsis. To iden...
Aspergillus fumigatus (Af) is one of the most ubiquitous fungi and its infection potency is suggested to be strongly controlled by the host genetic background. The aim of this study was to search for ...
We studied 31 male mice from 25 CC lines at 8 weeks old; the mice were infected with Af. Liver tissues were extracted from these mice 5 days post-infection, and next-generation RNA-sequencing (RNAseq)...
Significant variation in body weight changes between CC lines was observed. Hepatic gene expression revealed 12 top prioritized candidate genes differentially expressed in resistant versus susceptible...
Our findings emphasize the CC mouse model's power in fine mapping the genetic components underlying susceptibility towards Af. As a next step, eQTL analysis will be performed for our RNA-Seq data. Sug...
A chronic metabolic illness, type 2 diabetes (T2D) is a polygenic and multifactorial complicated disease. With an estimated 463 million persons aged 20 to 79 having diabetes, the number is expected to...
Committee work is a requisite job function for many in academia, yet designing a productive collaborative experience often remains a challenge. In this article, we reflect on our experiences as part o...
Anterior open bite malocclusion is a complex dental condition characterized by a lack of contact or overlap between the upper and lower front teeth. It can lead to difficulties with speech, chewing, a...
Youth mental health is a major health concern in almost every country. Mental health accounts for about 13% of the global burden of disease in the 10-to-19-year age group. Still there are significant ...
We conducted 42 interviews (November 2020 to March 2022) with health and social care professionals and managers in the youth mental health system in Sweden. Interviews explored participants' experienc...
The analysis produced three themes. The first shows that collaboration is considered as essential and important, and that it serves diverse purposes and holds multiple meanings in relation to professi...
We conclude that collaboration serves multiple purposes and takes many shapes in the Swedish youth mental health system. Despite the many challenges, participants saw potential in further building col...