Glucocorticoid gene regulation of aquaporin-7.
AQP7
Cortisone
GK activity
Glycerol
HSD1B11
Journal
Vitamins and hormones
ISSN: 0083-6729
Titre abrégé: Vitam Horm
Pays: United States
ID NLM: 0413601
Informations de publication
Date de publication:
2020
2020
Historique:
entrez:
17
2
2020
pubmed:
18
2
2020
medline:
2
4
2021
Statut:
ppublish
Résumé
AQP7 is the primary glycerol transporter in white (WAT) and brown (BAT) adipose tissues. There are immediate and quantitatively important actions of cortisone over the expression of AQP7 in murine and human adipocytes. Short-term response (minutes) of cortisone treatment result in an mRNA overexpression in white and brown differentiated adipocytes (between 1.5 and 6 folds). Conversely, long-term response (hours or days) result in decreased mRNA expression. The effects observed on AQP7 mRNA expression upon cortisone treatment in brown and white differentiated adipocytes are concordant with those observed for GK and HSD1B11.
Identifiants
pubmed: 32061341
pii: S0083-6729(19)30065-2
doi: 10.1016/bs.vh.2019.08.005
pii:
doi:
Substances chimiques
AQP7 protein, human
0
Aquaporins
0
Glucocorticoids
0
RNA, Messenger
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
179-207Informations de copyright
© 2020 Elsevier Inc. All rights reserved.