Adipose Tissue-Liver Cross Talk in the Control of Whole-Body Metabolism: Implications in Nonalcoholic Fatty Liver Disease.
Adipokines
/ metabolism
Adipose Tissue
/ metabolism
Adiposity
Animals
Blood Glucose
/ metabolism
Energy Metabolism
Humans
Hyperglycemia
/ epidemiology
Inflammation Mediators
/ metabolism
Insulin Resistance
Liver
/ metabolism
Non-alcoholic Fatty Liver Disease
/ diagnosis
Obesity
/ diagnosis
Prognosis
Risk Factors
Signal Transduction
Adipose Tissue
Fatty Acid Flux
Metabolism
Nonalcoholic Fatty Liver Disease
Journal
Gastroenterology
ISSN: 1528-0012
Titre abrégé: Gastroenterology
Pays: United States
ID NLM: 0374630
Informations de publication
Date de publication:
05 2020
05 2020
Historique:
received:
20
09
2019
revised:
20
11
2019
accepted:
04
12
2019
pubmed:
18
2
2020
medline:
16
2
2021
entrez:
17
2
2020
Statut:
ppublish
Résumé
Adipose tissue and the liver play significant roles in the regulation of whole-body energy homeostasis, but they have not evolved to cope with the continuous, chronic, nutrient surplus seen in obesity. In this review, we detail how prolonged metabolic stress leads to adipose tissue dysfunction, inflammation, and adipokine release that results in increased lipid flux to the liver. Overall, the upshot of hepatic fat accumulation alongside an insulin-resistant state is that hepatic lipid enzymatic pathways are modulated and overwhelmed, resulting in the selective buildup of toxic lipid species, which worsens the pro-inflammatory and pro-fibrotic shift observed in nonalcoholic steatohepatitis.
Identifiants
pubmed: 32061598
pii: S0016-5085(20)30224-9
doi: 10.1053/j.gastro.2019.12.054
pii:
doi:
Substances chimiques
Adipokines
0
Blood Glucose
0
Inflammation Mediators
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
1899-1912Subventions
Organisme : Medical Research Council
ID : MC_G0802535
Pays : United Kingdom
Organisme : Medical Research Council
ID : MC_UU_12012/2
Pays : United Kingdom
Organisme : Medical Research Council
ID : MC_UU_00014/2
Pays : United Kingdom
Organisme : British Heart Foundation
ID : RG/18/7/33636
Pays : United Kingdom
Organisme : Biotechnology and Biological Sciences Research Council
ID : BB/H002731/1
Pays : United Kingdom
Organisme : Medical Research Council
ID : G0600717
Pays : United Kingdom
Organisme : Medical Research Council
ID : G0802051
Pays : United Kingdom
Organisme : Medical Research Council
ID : MC_UU_12012/5
Pays : United Kingdom
Organisme : Medical Research Council
ID : G0400192
Pays : United Kingdom
Organisme : Medical Research Council
ID : MC_PC_13030
Pays : United Kingdom
Organisme : Medical Research Council
ID : PO 4050281695
Pays : United Kingdom
Informations de copyright
Copyright © 2020 AGA Institute. Published by Elsevier Inc. All rights reserved.